دورية أكاديمية
Circulating free insulin-like growth factor-I and prostate cancer: a case-control study nested in the European prospective investigation into cancer and nutrition.
العنوان: | Circulating free insulin-like growth factor-I and prostate cancer: a case-control study nested in the European prospective investigation into cancer and nutrition. |
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المؤلفون: | Cheng TS; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, OX3 7LF, UK., Noor U; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, OX3 7LF, UK., Watts E; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Pollak M; Oncology Department, McGill University and Segal Cancer Centre, Jewish General Hospital, Montreal, QC, Canada., Wang Y; Oncology Department, McGill University and Segal Cancer Centre, Jewish General Hospital, Montreal, QC, Canada., McKay J; Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France., Atkins J; Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France., Masala G; Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy., Sánchez MJ; Escuela Andaluza de Salud Pública (EASP), Granada, 18011, Spain.; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, 18012, Spain.; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, 28029, Spain.; Department of Preventive Medicine and Public Health, University of Granada, Granada, 18071, Spain., Agudo A; Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, L'Hospitalet de Llobregat, Barcelona, Spain.; Nutrition and Cancer Group; Epidemiology, Public Health, Cancer Prevention and Palliative Care Program; Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain., Castilla J; Instituto de Salud Pública de Navarra - IdiSNA, Pamplona, Spain.; CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain., Aune D; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Nutrition, Oslo New University College, Oslo, Norway.; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital Ullevå, Oslo, Norway., Colorado-Yohar SM; Department of Epidemiology, Murcia Regional Health Council-IMIB, Murcia, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia., Manfredi L; Centre for Biostatistics, Epidemiology, and Public Health (C-BEPH), Department of Clinical and Biological Sciences, University of Turin, Orbassano, TO, Italy., Gunter MJ; Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC- WHO), Lyon, France., Pala V; Epidemiology and Prevention Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Josefsson A; Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Wallenberg Center for Molecular Medicin, Umeå University, Umeå, Sweden.; Department of Urology and Andrology, Institute of surgery and perioperative Sciences, Umeå University, Umeå, Sweden., Key TJ; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, OX3 7LF, UK., Smith-Byrne K; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, OX3 7LF, UK., Travis RC; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, OX3 7LF, UK. ruth.travis@ndph.ox.ac.uk. |
المصدر: | BMC cancer [BMC Cancer] 2024 Jun 03; Vol. 24 (1), pp. 676. Date of Electronic Publication: 2024 Jun 03. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : BioMed Central, [2001- |
مواضيع طبية MeSH: | Prostatic Neoplasms*/blood , Prostatic Neoplasms*/epidemiology , Prostatic Neoplasms*/pathology , Insulin-Like Growth Factor I*/metabolism , Insulin-Like Growth Factor I*/analysis, Humans ; Male ; Middle Aged ; Case-Control Studies ; Prospective Studies ; Europe/epidemiology ; Aged ; Risk Factors ; Biomarkers, Tumor/blood ; Insulin-Like Peptides |
مستخلص: | Background: Circulating total insulin-like growth factor-I (IGF-I) is an established risk factor for prostate cancer. However, only a small proportion of circulating IGF-I is free or readily dissociable from IGF-binding proteins (its bioavailable form), and few studies have investigated the association of circulating free IGF-I with prostate cancer risk. Methods: We analyzed data from 767 prostate cancer cases and 767 matched controls nested within the European Prospective Investigation into Cancer and Nutrition cohort, with an average of 14-years (interquartile range = 2.9) follow-up. Matching variables were study center, length of follow-up, age, and time of day and fasting duration at blood collection. Circulating free IGF-I concentration was measured in serum samples collected at recruitment visit (mean age 55 years old; standard deviation = 7.1) using an enzyme-linked immunosorbent assay (ELISA). Conditional logistic regressions were performed to examine the associations of free IGF-I with risk of prostate cancer overall and subdivided by time to diagnosis (≤ 14 and > 14 years), and tumor characteristics. Results: Circulating free IGF-I concentrations (in fourths and as a continuous variable) were not associated with prostate cancer risk overall (odds ratio [OR] = 1.00 per 0.1 nmol/L increment, 95% CI: 0.99, 1.02) or by time to diagnosis, or with prostate cancer subtypes, including tumor stage and histological grade. Conclusions: Estimated circulating free IGF-I was not associated with prostate cancer risk. Further research may consider other assay methods that estimate bioavailable IGF-I to provide more insight into the well-substantiated association between circulating total IGF-I and subsequent prostate cancer risk. (© 2024. The Author(s).) |
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فهرسة مساهمة: | Keywords: Aggressiveness; Free IGF-1; Histological grade; Prostate cancer; Tumor stage |
المشرفين على المادة: | 67763-96-6 (Insulin-Like Growth Factor I) 0 (IGF1 protein, human) 0 (Biomarkers, Tumor) 0 (Insulin-Like Peptides) |
تواريخ الأحداث: | Date Created: 20240603 Date Completed: 20240604 Latest Revision: 20240607 |
رمز التحديث: | 20240607 |
مُعرف محوري في PubMed: | PMC11145848 |
DOI: | 10.1186/s12885-023-11425-w |
PMID: | 38831273 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1471-2407 |
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DOI: | 10.1186/s12885-023-11425-w |