دورية أكاديمية
أعرض في EDS

Association of blood urea nitrogen with all-cause and cardiovascular mortality in hyperlipidemia: NHANES 1999-2018.

التفاصيل البيبلوغرافية
العنوان: Association of blood urea nitrogen with all-cause and cardiovascular mortality in hyperlipidemia: NHANES 1999-2018.
المؤلفون: Shen J; Institute of Geriatrics, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, 152 Aiguo Road, Nanchang, Jiangxi, 330006, P.R. China.; School of Public Health, Nanchang University, Nanchang, Jiangxi, 330029, China., Wang Z; Institute of Geriatrics, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, 152 Aiguo Road, Nanchang, Jiangxi, 330006, P.R. China.; School of Public Health, Nanchang University, Nanchang, Jiangxi, 330029, China., Liu Y; School of Public Health, Nanchang University, Nanchang, Jiangxi, 330029, China., Wang T; Institute of Geriatrics, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, 152 Aiguo Road, Nanchang, Jiangxi, 330006, P.R. China., Wang XY; Institute of Geriatrics, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, 152 Aiguo Road, Nanchang, Jiangxi, 330006, P.R. China., Qu XH; The Second Department of Neurology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, 152 Aiguo Road, Nanchang, Jiangxi, 330006, P.R. China., Chen ZP; Institute of Geriatrics, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, 152 Aiguo Road, Nanchang, Jiangxi, 330006, P.R. China., Han XJ; Institute of Geriatrics, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, 152 Aiguo Road, Nanchang, Jiangxi, 330006, P.R. China. hanxiaojian@hotmail.com.; The Second Department of Neurology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, 152 Aiguo Road, Nanchang, Jiangxi, 330006, P.R. China. hanxiaojian@hotmail.com.
المصدر: Lipids in health and disease [Lipids Health Dis] 2024 Jun 03; Vol. 23 (1), pp. 164. Date of Electronic Publication: 2024 Jun 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101147696 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-511X (Electronic) Linking ISSN: 1476511X NLM ISO Abbreviation: Lipids Health Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2002-
مواضيع طبية MeSH: Hyperlipidemias*/blood , Hyperlipidemias*/mortality , Blood Urea Nitrogen* , Cardiovascular Diseases*/mortality , Cardiovascular Diseases*/blood , Nutrition Surveys*, Humans ; Male ; Female ; Middle Aged ; Proportional Hazards Models ; Aged ; Adult ; Risk Factors
مستخلص: Objective: Although blood urea nitrogen (BUN) has a crucial impact on many diseases, its effect on outcomes in patients with hyperlipidemia remains unknown. The study aimed to investigate the relationships between BUN levels and all-cause and cardiovascular disease (CVD) mortality in individuals with hyperlipidemia.
Methods: This analysis comprised 28,122 subjects with hyperlipidemia from the National Health and Nutrition Examination Survey (NHANES) spanning 1999 to 2018. The risk of BUN on mortality was evaluated using weighted Cox regression models. Additionally, to illustrate the dose-response association, the restricted cubic spline (RCS) was used.
Results: During the observation period, 4276 participant deaths were recorded, of which 1206 were due to CVD. Compared to patients with hyperlipidemia in the third BUN quintile, the hazard ratios (HRs) for all-cause mortality were 1.26 (95% CIs: 1.09, 1.45) and 1.22 (95% CIs: 1.09, 1.37) for patients in the first and fifth quintiles of BUN, respectively. The HRs for CVD mortality among patients in the fifth quintile of BUN were 1.48 (95% CIs: 1.14, 1.93). BUN levels were found to have a U-shaped association with all-cause mortality and a linear association with CVD mortality using restricted triple spline analysis.
Conclusions: This study revealed that both low and high BUN levels in patients with hyperlipidemia are associated with heightened all-cause mortality. Furthermore, elevated BUN levels are also associated with increased CVD mortality. The findings indicate that patients with hyperlipidemia may face an elevated risk of death if they have abnormal BUN levels.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 20224ACB206014 the Natural Science Foundation of Jiangxi Province; 20224ACB206014 the Natural Science Foundation of Jiangxi Province; 20224ACB206014 the Natural Science Foundation of Jiangxi Province; 20224ACB206014 the Natural Science Foundation of Jiangxi Province; 20224ACB206014 the Natural Science Foundation of Jiangxi Province; 20224ACB206014 the Natural Science Foundation of Jiangxi Province; 20224ACB206014 the Natural Science Foundation of Jiangxi Province; 2023ZD001 The Key Science and Technology Innovation Project of Jiangxi Provincial Health Commission; 2023ZD001 The Key Science and Technology Innovation Project of Jiangxi Provincial Health Commission; 2023ZD001 The Key Science and Technology Innovation Project of Jiangxi Provincial Health Commission; 2023ZD001 The Key Science and Technology Innovation Project of Jiangxi Provincial Health Commission; 2023ZD001 The Key Science and Technology Innovation Project of Jiangxi Provincial Health Commission; 2023ZD001 The Key Science and Technology Innovation Project of Jiangxi Provincial Health Commission; 2023ZD001 The Key Science and Technology Innovation Project of Jiangxi Provincial Health Commission; GJJ218902 the Key Projects from Department of Education of Jiangxi Province; GJJ218902 the Key Projects from Department of Education of Jiangxi Province
فهرسة مساهمة: Keywords: Blood urea nitrogen; Mortality; NHANES; Patients with hyperlipidemia
تواريخ الأحداث: Date Created: 20240603 Date Completed: 20240604 Latest Revision: 20240607
رمز التحديث: 20240607
مُعرف محوري في PubMed: PMC11145831
DOI: 10.1186/s12944-024-02158-1
PMID: 38831466
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-511X
DOI:10.1186/s12944-024-02158-1