دورية أكاديمية
أعرض في EDS

Potential Immune-Inflammatory Proteome Biomarkers for Guiding the Treatment of Patients with Primary Acute Angle-Closure Glaucoma Caused by COVID-19.

التفاصيل البيبلوغرافية
العنوان: Potential Immune-Inflammatory Proteome Biomarkers for Guiding the Treatment of Patients with Primary Acute Angle-Closure Glaucoma Caused by COVID-19.
المؤلفون: Gong Q; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.; National Clinical Research Center for Eye Diseases, Shanghai 200080, China.; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai 200080, China.; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, China.; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Disease, Shanghai 200080, China., Fu M; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.; National Clinical Research Center for Eye Diseases, Shanghai 200080, China.; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai 200080, China.; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, China.; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Disease, Shanghai 200080, China., Wang J; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.; National Clinical Research Center for Eye Diseases, Shanghai 200080, China.; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai 200080, China.; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, China.; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Disease, Shanghai 200080, China., Zhao S; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.; National Clinical Research Center for Eye Diseases, Shanghai 200080, China.; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai 200080, China.; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, China.; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Disease, Shanghai 200080, China., Wang H; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.; National Clinical Research Center for Eye Diseases, Shanghai 200080, China.; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai 200080, China.; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, China.; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Disease, Shanghai 200080, China.
المصدر: Journal of proteome research [J Proteome Res] 2024 Jul 05; Vol. 23 (7), pp. 2587-2597. Date of Electronic Publication: 2024 Jun 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101128775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3907 (Electronic) Linking ISSN: 15353893 NLM ISO Abbreviation: J Proteome Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, D.C. : American Chemical Society, c2002-
مواضيع طبية MeSH: Glaucoma, Angle-Closure*/metabolism , Glaucoma, Angle-Closure*/immunology , COVID-19*/immunology , COVID-19*/complications , Biomarkers*/metabolism , Proteome*/analysis , SARS-CoV-2*, Humans ; Male ; Female ; Aged ; Middle Aged ; Aqueous Humor/virology ; Aqueous Humor/metabolism ; Inflammation/metabolism ; Proteomics/methods ; Cataract/metabolism ; Acute Disease
مستخلص: Primary acute angle-closure glaucoma (PAACG) is a sight-threatening condition that can lead to blindness. With the increasing incidence of COVID-19, a multitude of people are experiencing acute vision loss and severe swelling of the eyes and head. These patients were then diagnosed with acute angle closure, with or without a history of PACG. However, the mechanism by which viral infection causes PACG has not been clarified. This is the first study to explore the specific inflammatory proteomic landscape in SARS-CoV-2-induced PAACG. The expression of 92 inflammation-related proteins in 19 aqueous humor samples from PAACGs or cataract patients was detected using the Olink Target 96 Inflammation Panel based on a highly sensitive and specific proximity extension assay technology. The results showed that 76 proteins were significantly more abundant in the PAACG group than in the cataract group. Notably, the top eight differentially expressed proteins were IL-8, MCP-1, TNFRSF9, DNER, CCL4, Flt3L, CXCL10, and CD40. Generally, immune markers are related to inflammation, macrophage activation, and viral infection, revealing the crucial role of macrophages in the occurrence of PAACGs caused by SARS-CoV-2.
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فهرسة مساهمة: Keywords: COVID-19; cytokine; inflammation; macrophage; primary angle-closure glaucoma
المشرفين على المادة: 0 (Biomarkers)
0 (Proteome)
تواريخ الأحداث: Date Created: 20240605 Date Completed: 20240705 Latest Revision: 20240711
رمز التحديث: 20240711
مُعرف محوري في PubMed: PMC11232099
DOI: 10.1021/acs.jproteome.4c00325
PMID: 38836775
قاعدة البيانات: MEDLINE
الوصف
تدمد:1535-3907
DOI:10.1021/acs.jproteome.4c00325