دورية أكاديمية
Biyang floral mushroom-derived exosome-like nanovesicles: characterization, absorption stability and ionizing radiation protection.
| العنوان: | Biyang floral mushroom-derived exosome-like nanovesicles: characterization, absorption stability and ionizing radiation protection. |
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| المؤلفون: | Ling Y; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China. yijuanjuanmsn@126.com.; Food Laboratory of Zhongyuan, Luohe 462300, China., Li X; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China. yijuanjuanmsn@126.com.; Food Laboratory of Zhongyuan, Luohe 462300, China., Gao H; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China. yijuanjuanmsn@126.com.; Food Laboratory of Zhongyuan, Luohe 462300, China., Liu Y; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China. yijuanjuanmsn@126.com., Liu Y; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China. yijuanjuanmsn@126.com.; Food Laboratory of Zhongyuan, Luohe 462300, China., Zheng J; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China. yijuanjuanmsn@126.com.; Food Laboratory of Zhongyuan, Luohe 462300, China., Zhu J; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China. yijuanjuanmsn@126.com.; Food Laboratory of Zhongyuan, Luohe 462300, China., Zhao C; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China. yijuanjuanmsn@126.com.; Food Laboratory of Zhongyuan, Luohe 462300, China., Shi Y; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China. yijuanjuanmsn@126.com.; Food Laboratory of Zhongyuan, Luohe 462300, China., Lu J; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China. yijuanjuanmsn@126.com.; Food Laboratory of Zhongyuan, Luohe 462300, China., Yi J; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China. yijuanjuanmsn@126.com.; Food Laboratory of Zhongyuan, Luohe 462300, China. |
| المصدر: | Food & function [Food Funct] 2024 Jul 01; Vol. 15 (13), pp. 6900-6913. Date of Electronic Publication: 2024 Jul 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101549033 Publication Model: Electronic Cited Medium: Internet ISSN: 2042-650X (Electronic) Linking ISSN: 20426496 NLM ISO Abbreviation: Food Funct Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Royal Society of Chemistry |
| مواضيع طبية MeSH: | Radiation-Protective Agents*/pharmacology , Radiation-Protective Agents*/chemistry , Exosomes*/metabolism , Radiation, Ionizing*, Humans ; Animals ; Mice ; Caco-2 Cells ; Male ; Agaricales/chemistry ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Oxidative Stress/drug effects |
| مستخلص: | Diet-derived exosome-like nanovesicles are a class of natural active substances that have similar structures and functions to mammalian exosomes. Biyang floral mushrooms and their active extracts have been found to possess radioprotective effects and to deeply explore their novel active substances, the radioprotective effects of Biyang floral mushroom-derived exosome-like nanovesicles (BFMELNs) were investigated in this study. Results showed that these surface-negatively charged vesicles possessed an ideal size and good stability against environmental changes such as temperature and gastrointestinal digestion. Furthermore, BFMELNs could effectively be taken up by HL-7702 cells and Caco-2 cells through cellular phagocytosis mediated by clathrin and dynein. Emphatically, BFMELNs with an exosome-like morphology contained RNA, proteins, lipids, polyphenols and flavonoids to exert good antioxidant and radioprotective effects in vitro . Meanwhile, BFMELNs also exhibited good radioprotective effects by restoring peripheral blood indexes, mitigating damage to organs, and regulating the redox state in mice. Collectively, BFMELNs showed promise as novel and natural radioprotective nano-agents for preventing IR-induced oxidative stress damage. |
| المشرفين على المادة: | 0 (Radiation-Protective Agents) 0 (Antioxidants) |
| تواريخ الأحداث: | Date Created: 20240605 Date Completed: 20240701 Latest Revision: 20240701 |
| رمز التحديث: | 20240701 |
| DOI: | 10.1039/d4fo00263f |
| PMID: | 38837182 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2042-650X |
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| DOI: | 10.1039/d4fo00263f |