دورية أكاديمية
PREDICT HF: Risk stratification in advanced heart failure using novel hemodynamic parameters.
| العنوان: | PREDICT HF: Risk stratification in advanced heart failure using novel hemodynamic parameters. |
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| المؤلفون: | Cyrille-Superville N; Sanger Heart and Vascular Institute, Atrium Health, Charlotte, North Carolina, USA., Rao SD; Department of Medicine, Medstar Washington Hospital Center, Division of Cardiology, Georgetown University, Washington, District of Columbia, USA., Feliberti JP; University of South Florida Heart and Vascular Institute, Transplant Cardiology, Tampa, Florida, USA., Patel PA; Sanger Heart and Vascular Institute, Atrium Health, Charlotte, North Carolina, USA., Swayampakala K; Sanger Heart and Vascular Institute, Atrium Health, Charlotte, North Carolina, USA., Sinha SS; Inova Heart and Vascular Institute, Inova Fairfax Medical Campus, Falls Church, Virginia, USA., Jeng EI; Department of Surgery, Division of Cardiovascular Surgery, University of Florida, Gainesville, Florida, USA., Goswami RM; Division of Transplant, Research and Innovation, Mayo Clinic in Florida, Jacksonville, Florida, USA., Snipelisky DF; Section of Heart Failure & Cardiac Transplant Medicine, Cleveland Clinic Florida, Weston, Florida, USA., Carroll AM; Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA., Najjar SS; Medstar Heart and Vascular Institute, Baltimore, Maryland, USA., Belkin M; Department of Medicine, Section of Cardiology, University of Chicago, Chicago, Illinois, USA., Grinstein J; Department of Medicine, Section of Cardiology, University of Chicago, Chicago, Illinois, USA. |
| مؤلفون مشاركون: | FLIGHT Working Group |
| المصدر: | Clinical cardiology [Clin Cardiol] 2024 Jun; Vol. 47 (6), pp. e24277. |
| نوع المنشور: | Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 7903272 Publication Model: Print Cited Medium: Internet ISSN: 1932-8737 (Electronic) Linking ISSN: 01609289 NLM ISO Abbreviation: Clin Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hoboken, NJ : John Wiley & Sons, Inc Original Publication: New York : G. Witzstrock |
| مواضيع طبية MeSH: | Heart Failure*/physiopathology , Heart Failure*/diagnosis , Heart Failure*/therapy , Heart Failure*/mortality , Hemodynamics*/physiology , Cardiac Catheterization* , Registries*, Humans ; Male ; Female ; Middle Aged ; Risk Assessment/methods ; Prognosis ; Aged ; Risk Factors ; Pulmonary Wedge Pressure/physiology ; Heart-Assist Devices ; Heart Transplantation ; Retrospective Studies ; United States/epidemiology ; Time Factors ; Predictive Value of Tests ; Ventricular Function, Left/physiology |
| مستخلص: | Background: Invasive hemodynamics are fundamental in assessing patients with advanced heart failure (HF). Several novel hemodynamic parameters have been studied; however, the relative prognostic potential remains ill-defined. Hypothesis: Advanced hemodynamic parameters provide additional prognostication beyond the standard hemodynamic assessment. Methods: Patients from the PRognostic Evaluation During Invasive CaTheterization for Heart Failure (PREDICT-HF) registry who underwent right heart catheterization (RHC) were included in the analysis. The primary endpoint was survival to orthotopic heart transplant (OHT) or durable left ventricular assist device (LVAD), or death within 6 months of RHC. Results: Of 846 patients included, 176 (21%) met the primary endpoint. In a multivariate model that included traditional hemodynamic variables, pulmonary capillary wedge pressure (PCWP) (OR: 1.10, 1.04-1.15, p < .001), and cardiac index (CI) (OR: 0.86, 0.81-0.92, p < .001) were shown to be predictive of adverse outcomes. In a separate multivariate model that incorporated advanced hemodynamic parameters, cardiac power output (CPO) (OR: 0.76, 0.71-0.83, p < .001), aortic pulsatility index (API) (OR: 0.94, 0.91-0.96, p < .001), and pulmonary artery pulsatility index (OR: 1.02, 1.00-1.03, p .027) were all significantly associated with the primary outcome. Positively concordant API and CPO afforded the best freedom from the endpoint (94.7%), whilst negatively concordant API and CPO had the worst freedom from the endpoint (61.5%, p < .001). Those with discordant API and CPO had similar freedom from the endpoint. Conclusion: The advanced hemodynamic parameters API and CPO are independently associated with death or the need for OHT or LVAD within 6 months. Further prospective studies are needed to validate these parameters and elucidate their role in patients with advanced HF. (© 2024 The Authors. Clinical Cardiology published by Wiley Periodicals, LLC.) |
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| فهرسة مساهمة: | Keywords: heart failure; novel hemodynamics; prognostication |
| تواريخ الأحداث: | Date Created: 20240605 Date Completed: 20240605 Latest Revision: 20240719 |
| رمز التحديث: | 20240719 |
| مُعرف محوري في PubMed: | PMC11151004 |
| DOI: | 10.1002/clc.24277 |
| PMID: | 38838029 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1932-8737 |
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| DOI: | 10.1002/clc.24277 |