دورية أكاديمية
Local complement activation and modulation in mucosal immunity.
| العنوان: | Local complement activation and modulation in mucosal immunity. |
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| المؤلفون: | Kulkarni DH; Division of Gastroenterology, Washington University School of Medicine, St. Louis, MO, USA., Starick M; Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, USA., Aponte Alburquerque R; Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, USA., Kulkarni HS; Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: hkulkarn@wustl.edu. |
| المصدر: | Mucosal immunology [Mucosal Immunol] 2024 Aug; Vol. 17 (4), pp. 739-751. Date of Electronic Publication: 2024 Jun 04. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101299742 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1935-3456 (Electronic) Linking ISSN: 19330219 NLM ISO Abbreviation: Mucosal Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [New York, NY] : Elsevier Original Publication: New York, NY : Nature Pub. Group, c2008- |
| مواضيع طبية MeSH: | Complement Activation* , Immunity, Mucosal* , Complement System Proteins*/immunology , Complement System Proteins*/metabolism, Humans ; Animals ; Immunomodulation ; Immunity, Innate |
| مستخلص: | The complement system is an evolutionarily conserved arm of innate immunity, which forms one of the first lines of host response to pathogens and assists in the clearance of debris. A deficiency in key activators/amplifiers of the cascade results in recurrent infection, whereas a deficiency in regulating the cascade predisposes to accelerated organ failure, as observed in colitis and transplant rejection. Given that there are over 60 proteins in this system, it has become an attractive target for immunotherapeutics, many of which are United States Food and Drug Administration-approved or in multiple phase 2/3 clinical trials. Moreover, there have been key advances in the last few years in the understanding of how the complement system operates locally in tissues, independent of its activities in circulation. In this review, we will put into perspective the abovementioned discoveries to optimally modulate the spatiotemporal nature of complement activation and regulation at mucosal surfaces. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| معلومات مُعتمدة: | R01 HL169860 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: ATG7; C3 F/S; C3 fast/slow; CCAAT; CXCL; DSS; FXR; HSV-1; ICAM; IRF; JAK1/2; Janus kinase ½; MAPK; MMP; NLRP3; PPAR; PTEN; RELA - v-rel; ROS; STAT1; VEGF-A; autophagy related 7; chemokine (C-X-C motif) ligand; cytosine-cytosine-adenosine-adenosine-thymidine; dextran sodium sulfate; farnesoid X receptor; herpes simplex virus-1; intercellular adhesion molecule; interferon regulatory factor; matrix metalloproteinase; mitogen-activated protein kinase; nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3; peroxisome proliferator-activated receptor; phosphatase and tensin homolog; reactive oxygen species; reticuloendotheliosis viral oncogene homolog A (avian); signal transducer and activation of transcription 1; vascular endothelial growth factor-A |
| المشرفين على المادة: | 9007-36-7 (Complement System Proteins) |
| تواريخ الأحداث: | Date Created: 20240605 Date Completed: 20240812 Latest Revision: 20240812 |
| رمز التحديث: | 20240813 |
| DOI: | 10.1016/j.mucimm.2024.05.006 |
| PMID: | 38838816 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1935-3456 |
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| DOI: | 10.1016/j.mucimm.2024.05.006 |