دورية أكاديمية
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Phasic Stimulation of Dopaminergic Neurons of the Lateral Substantia Nigra Increases Open Field Exploratory Behaviour and Reduces Habituation Over Time.

التفاصيل البيبلوغرافية
العنوان: Phasic Stimulation of Dopaminergic Neurons of the Lateral Substantia Nigra Increases Open Field Exploratory Behaviour and Reduces Habituation Over Time.
المؤلفون: Young PA; Department of Biology, University of Victoria, British Columbia V8W 2Y2, Canada; Division of Medical Sciences, University of Victoria, British Columbia V8W 2Y2, Canada., Waller O; Department of Biology, University of Victoria, British Columbia V8W 2Y2, Canada., Ball K; Department of Biology, University of Victoria, British Columbia V8W 2Y2, Canada., Williams CC; Carney Institute for Brain Science, Brown University, Providence, RI 02912, USA., Nashmi R; Department of Biology, University of Victoria, British Columbia V8W 2Y2, Canada; Division of Medical Sciences, University of Victoria, British Columbia V8W 2Y2, Canada. Electronic address: raad@uvic.ca.
المصدر: Neuroscience [Neuroscience] 2024 Jul 23; Vol. 551, pp. 276-289. Date of Electronic Publication: 2024 Jun 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE
أسماء مطبوعة: Publication: [New York?] : Elsevier Science
Original Publication: Oxford, Elmsford, N. Y., Pergamon Press
مواضيع طبية MeSH: Dopaminergic Neurons*/physiology , Dopaminergic Neurons*/metabolism , Mice, Transgenic* , Exploratory Behavior*/physiology , Substantia Nigra*/physiology , Substantia Nigra*/metabolism , Habituation, Psychophysiologic*/physiology, Animals ; Male ; Female ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Mice ; Optogenetics ; Locomotion/physiology ; Mice, Inbred C57BL ; Channelrhodopsins/metabolism ; Channelrhodopsins/genetics ; Motor Activity/physiology
مستخلص: Transient nigrostriatal dopaminergic signalling is well known for its role in reinforcement learning and increasingly so for its role in the initiation of voluntary movement. However, how transient bursts of dopamine modulate voluntary movement remains unclear, likely due to the heterogeneity of the nigrostriatal system, the focus of optogenetic studies on locomotion at sub-sec time intervals, and the overlapping roles of phasic dopamine in behaviour and novelty signalling. In this study we investigated how phasic activity in the lateral substantia nigra pars compacta (lateral SNc) over time affects voluntary behaviours during exploration. Using a transgenic mouse model of both sexes expressing channelrhodopsin (ChR2) in dopamine transporter-expressing cells, we stimulated the lateral SNc while mice explored an open field over two consecutive days. We found that phasic activation of the lateral SNc induced an increase in exploratory behaviours including horizontal movement activity, locomotion initiation, and rearing specifically on the first open field exposure, but not on the second day. In addition, stimulated animals did not habituate to the same extent as their ChR2-negative counterparts, as indicated by a lack of decrease in baseline activity. These findings suggest that rather than prompting voluntary movement in general, phasic nigrostriatal dopamine prompts context-appropriate behaviours. In addition, dopamine signalling that modulates movement acts over longer timescales than the transient signal, affecting behaviour even after the signal has ended.
(Copyright © 2024 IBRO. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: channelrhodopsin; exploratory behaviour; locomotion; movement; optogenetics; rearing
المشرفين على المادة: 0 (Dopamine Plasma Membrane Transport Proteins)
0 (Channelrhodopsins)
تواريخ الأحداث: Date Created: 20240605 Date Completed: 20240712 Latest Revision: 20240712
رمز التحديث: 20240713
DOI: 10.1016/j.neuroscience.2024.05.025
PMID: 38838978
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-7544
DOI:10.1016/j.neuroscience.2024.05.025