دورية أكاديمية
أعرض في EDS

Saponins from Allii Macrostemonis Bulbus attenuate atherosclerosis by inhibiting macrophage foam cell formation and inflammation.

التفاصيل البيبلوغرافية
العنوان: Saponins from Allii Macrostemonis Bulbus attenuate atherosclerosis by inhibiting macrophage foam cell formation and inflammation.
المؤلفون: Zhao S; Translational Medicine Centre, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China., Guo H; Translational Medicine Centre, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China., Qiu L; Translational Medicine Centre, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China., Zhong C; Translational Medicine Centre, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.; Department of Cardiovascular Sciences and Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA., Xue J; Translational Medicine Centre, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China., Qin M; Translational Medicine Centre, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China., Zhang Y; Translational Medicine Centre, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China., Xu C; Translational Medicine Centre, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China. xuchuanming2008@163.com., Xie Y; Translational Medicine Centre, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China. 1047501830@qq.com., Yu J; Department of Cardiovascular Sciences and Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
المصدر: Scientific reports [Sci Rep] 2024 Jun 05; Vol. 14 (1), pp. 12917. Date of Electronic Publication: 2024 Jun 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Foam Cells*/drug effects , Foam Cells*/metabolism , Atherosclerosis*/drug therapy , Atherosclerosis*/pathology , Atherosclerosis*/metabolism , Atherosclerosis*/prevention & control , Saponins*/pharmacology , Inflammation*/drug therapy , Inflammation*/pathology, Animals ; Mice ; Allium/chemistry ; Male ; Apolipoproteins E/deficiency ; Diet, High-Fat/adverse effects ; NF-kappa B/metabolism ; Mice, Inbred C57BL ; Lipoproteins, LDL/metabolism
مستخلص: Allii Macrostemonis Bulbus (AMB) is a traditional Chinese medicine with medicinal and food homology. AMB has various biological activities, including anti-coagulation, lipid-lowering, anti-tumor, and antioxidant effects. Saponins from Allium macrostemonis Bulbus (SAMB), the predominant beneficial compounds, also exhibited lipid-lowering and anti-inflammatory properties. However, the effect of SAMB on atherosclerosis and the underlying mechanisms are still unclear. This study aimed to elucidate the pharmacological impact of SAMB on atherosclerosis. In apolipoprotein E deficiency (ApoE -/- ) mice with high-fat diet feeding, oral SAMB administration significantly attenuated inflammation and atherosclerosis plaque formation. The in vitro experiments demonstrated that SAMB effectively suppressed oxidized-LDL-induced foam cell formation by down-regulating CD36 expression, thereby inhibiting lipid endocytosis in bone marrow-derived macrophages. Additionally, SAMB effectively blocked LPS-induced inflammatory response in bone marrow-derived macrophages potentially through modulating the NF-κB/NLRP3 pathway. In conclusion, SAMB exhibits a potential anti-atherosclerotic effect by inhibiting macrophage foam cell formation and inflammation. These findings provide novel insights into potential preventive and therapeutic strategies for the clinical management of atherosclerosis.
(© 2024. The Author(s).)
References: Curr Top Med Chem. 2005;5(3):265-82. (PMID: 15857310)
Nat Rev Cardiol. 2021 Oct;18(10):712-723. (PMID: 33833449)
Endocrinol Metab Clin North Am. 2022 Sep;51(3):655-679. (PMID: 35963634)
Nat Rev Drug Discov. 2021 Aug;20(8):589-610. (PMID: 33976384)
Chem Res Toxicol. 2021 Sep 20;34(9):2125-2134. (PMID: 34428026)
Circ Res. 2011 Apr 15;108(8):985-95. (PMID: 21350215)
Nature. 2019 May;569(7757):565-569. (PMID: 31019307)
Nat Rev Cardiol. 2022 Apr;19(4):228-249. (PMID: 34759324)
Molecules. 2023 Mar 08;28(6):. (PMID: 36985457)
Cardiovasc Res. 2023 Oct 24;119(13):2278-2293. (PMID: 37595265)
Open Heart. 2018 Jan 26;5(1):e000722. (PMID: 29387429)
Vascul Pharmacol. 2019 Jan;112:54-71. (PMID: 30115528)
Nat Commun. 2016 Nov 28;7:13457. (PMID: 27892461)
Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17511-6. (PMID: 19805174)
Phytomedicine. 2023 Oct;119:155002. (PMID: 37572566)
Circ Res. 2012 Mar 16;110(6):889-900. (PMID: 22427326)
Circ Res. 2023 May 26;132(11):1521-1545. (PMID: 37228232)
Eur J Pharmacol. 2008 Dec 3;599(1-3):159-65. (PMID: 18930725)
Nat Commun. 2023 Feb 18;14(1):929. (PMID: 36807553)
Curr Opin Lipidol. 2020 Oct;31(5):273-278. (PMID: 32773464)
Circulation. 2007 Oct 16;116(16):1832-44. (PMID: 17938300)
Br Med Bull. 2018 Jun 1;126(1):101-112. (PMID: 29534172)
Nat Rev Immunol. 2015 Feb;15(2):104-16. (PMID: 25614320)
Curr Drug Targets. 2011 May;12(5):647-60. (PMID: 21039336)
J Cell Mol Med. 2016 Jan;20(1):17-28. (PMID: 26493158)
Circ Res. 2016 Feb 19;118(4):653-67. (PMID: 26892964)
Nature. 2021 Apr;592(7855):524-533. (PMID: 33883728)
J Intern Med. 2015 Nov;278(5):483-93. (PMID: 26260307)
Nat Rev Immunol. 2010 Mar;10(3):210-5. (PMID: 20168318)
Chin J Nat Med. 2016 Jul;14(7):481-98. (PMID: 27507199)
Nat Rev Cardiol. 2019 Dec;16(12):727-744. (PMID: 31243391)
Cell Death Dis. 2023 Oct 20;14(10):691. (PMID: 37863894)
Exp Mol Med. 2014 Jun 06;46:e99. (PMID: 24903227)
Nat Commun. 2017 Jun 07;8:15750. (PMID: 28589926)
Nat Immunol. 2013 Aug;14(8):812-20. (PMID: 23812099)
Cells. 2022 Mar 17;11(6):. (PMID: 35326465)
Arterioscler Thromb Vasc Biol. 2003 Sep 1;23(9):1553-8. (PMID: 12869351)
Pharmacol Rev. 2019 Oct;71(4):596-670. (PMID: 31554644)
Circ Res. 2019 Dec 6;125(12):1087-1102. (PMID: 31625810)
Circulation. 2021 Feb 23;143(8):e254-e743. (PMID: 33501848)
Molecules. 2024 Mar 11;29(6):. (PMID: 38542876)
معلومات مُعتمدة: 82160051 National Natural Science Foundation of China; 32100908 National Natural Science Foundation of China
فهرسة مساهمة: Keywords: Atherosclerosis; Inflammation; Macrophage; Saponins from Allii Macrostemonis Bulbus
المشرفين على المادة: 0 (Saponins)
0 (Apolipoproteins E)
0 (NF-kappa B)
0 (Lipoproteins, LDL)
تواريخ الأحداث: Date Created: 20240605 Date Completed: 20240605 Latest Revision: 20240608
رمز التحديث: 20240608
مُعرف محوري في PubMed: PMC11153636
DOI: 10.1038/s41598-024-61209-w
PMID: 38839811
قاعدة البيانات: MEDLINE
كن أول من يترك تعليقا!
يجب تسجيل دخولك أولا