دورية أكاديمية
Biological Age, Chronological Age, and Survival in Pulmonary Fibrosis: A Causal Mediation Analysis.
| العنوان: | Biological Age, Chronological Age, and Survival in Pulmonary Fibrosis: A Causal Mediation Analysis. |
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| المؤلفون: | Pugashetti JV; Division of Pulmonary and Critical Care Medicine., Kim JS; Division of Pulmonary and Critical Care Medicine and., Bose S; Department of Biostatistics, and., Adegunsoye A; Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois., Linderholm AL; Division of Pulmonary, Critical Care and Sleep Medicine, University of California, Davis, Sacramento, California., Chen CH; Division of Pulmonary, Critical Care and Sleep Medicine, University of California, Davis, Sacramento, California., Strek ME; Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois., Flaherty KR; Division of Pulmonary and Critical Care Medicine.; Pulmonary Fibrosis Foundation, Chicago, Illinois., Murray S; Department of Biostatistics, and., Newton CA; Pulmonary Fibrosis Foundation, Chicago, Illinois.; Division of Pulmonary and Critical Care, University of Texas Southwestern, Dallas, Texas., Alqalyoobi S; Division of Pulmonary and Critical Care, East Carolina University, Greenville, North Carolina., Ma SF; Division of Pulmonary and Critical Care Medicine and., Mychaleckyj JC; School of Public Health Sciences, University of Virginia, Charlottesville, Virginia., Bowler RP; Division of Pulmonary Medicine, National Jewish Health, Denver, Colorado., Han MK; Division of Pulmonary and Critical Care Medicine., Curtis JL; Division of Pulmonary and Critical Care Medicine.; Medical Service, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan; and., Martinez FJ; Division of Pulmonary and Critical Care Medicine, Weill Cornell Medical Center, New York, New York., Smith JA; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan., Noth I; Division of Pulmonary and Critical Care Medicine and., Oldham JM; Division of Pulmonary and Critical Care Medicine.; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan. |
| المصدر: | American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2024 Sep 01; Vol. 210 (5), pp. 639-647. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Thoracic Society Country of Publication: United States NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2000- : New York, NY : American Thoracic Society Original Publication: New York, NY : American Lung Association, c1994- |
| مواضيع طبية MeSH: | Aging*/physiology , Idiopathic Pulmonary Fibrosis*/mortality , Idiopathic Pulmonary Fibrosis*/physiopathology , Idiopathic Pulmonary Fibrosis*/blood, Humans ; Male ; Female ; Aged ; Middle Aged ; Mediation Analysis ; Cohort Studies ; Survival Analysis ; Proteomics ; Aged, 80 and over ; Blood Proteins/metabolism |
| مستخلص: | Rationale: Accelerated biological aging has been implicated in the development of interstitial lung disease (ILD) and other diseases of aging but remains poorly understood. Objectives: To identify plasma proteins that mediate the relationship between chronological age and survival association in patients with ILD. Methods: Causal mediation analysis was performed to identify plasma proteins that mediated the chronological age-survival relationship in an idiopathic pulmonary fibrosis discovery cohort. Proteins mediating this relationship after adjustment for false discovery were advanced for testing in an independent ILD validation cohort and explored in a chronic obstructive pulmonary disease cohort. A proteomic-based measure of biological age was constructed and survival analysis performed, assessing the impact of biological age and peripheral blood telomere length on the chronological age-survival relationship. Measurements and Main Results: Twenty-two proteins mediated the chronological age-survival relationship after adjustment for false discovery in the idiopathic pulmonary fibrosis discovery cohort ( n = 874), with 19 remaining significant mediators of this relationship in the ILD validation cohort ( n = 983) and one mediating this relationship in the chronic obstructive pulmonary disease cohort. Latent transforming growth factor-β binding protein 2 and ectodysplasin A2 receptor showed the strongest mediation across cohorts. A proteomic measure of biological age completely attenuated the chronological age-survival association and better discriminated survival than chronological age. Results were robust to adjustment for peripheral blood telomere length, which did not mediate the chronological age-survival relationship. Conclusions: Molecular measures of aging completely mediate the relationship between chronological age and survival, suggesting that chronological age has no direct effect on ILD survival. |
| التعليقات: | Comment in: Am J Respir Crit Care Med. 2024 Sep 1;210(5):541-543. doi: 10.1164/rccm.202407-1290ED. (PMID: 39078175) |
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| معلومات مُعتمدة: | U01 HL137880 United States HL NHLBI NIH HHS; K23HL150301 United States HL NHLBI NIH HHS; K23HL146942 United States HL NHLBI NIH HHS; K23HL148498 United States HL NHLBI NIH HHS; RO1HL130796 United States HL NHLBI NIH HHS; UG3HL145266 United States HL NHLBI NIH HHS; U01 HL137880 United States HL NHLBI NIH HHS; R01 HL144718 United States HL NHLBI NIH HHS; R01HL169166 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: age; causal mediation; idiopathic pulmonary fibrosis; proteomics |
| المشرفين على المادة: | 0 (Blood Proteins) |
| تواريخ الأحداث: | Date Created: 20240606 Date Completed: 20240830 Latest Revision: 20240914 |
| رمز التحديث: | 20240914 |
| مُعرف محوري في PubMed: | PMC11389564 |
| DOI: | 10.1164/rccm.202310-1887OC |
| PMID: | 38843133 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1535-4970 |
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| DOI: | 10.1164/rccm.202310-1887OC |