دورية أكاديمية
The hippocampus dissociates present from past and future goals.
| العنوان: | The hippocampus dissociates present from past and future goals. |
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| المؤلفون: | Montagrin A; The Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. alison.montagrin@unige.ch.; Department of Neuroscience, University of Geneva, Geneva, 1202, Switzerland. alison.montagrin@unige.ch.; Swiss Center for Affective Sciences (CISA), University of Geneva, 1202, Geneva, Switzerland. alison.montagrin@unige.ch., Croote DE; The Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Preti MG; CIBM Center for Biomedical Imaging, Lausanne, Switzerland.; Neuro-X Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.; Department of Radiology and Medical Informatics, University of Geneva (UNIGE), Geneva, Switzerland., Lerman L; Sector 5 Digital, New York, NY, 10018, USA., Baxter MG; The Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Schiller D; The Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. daniela.schiller@mssm.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. daniela.schiller@mssm.edu. |
| المصدر: | Nature communications [Nat Commun] 2024 Jun 06; Vol. 15 (1), pp. 4815. Date of Electronic Publication: 2024 Jun 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
| مواضيع طبية MeSH: | Hippocampus*/physiology , Hippocampus*/diagnostic imaging , Magnetic Resonance Imaging*/methods , Goals* , Brain Mapping*/methods, Humans ; Male ; Female ; Adult ; Young Adult |
| مستخلص: | Our brain adeptly navigates goals across time frames, distinguishing between urgent needs and those of the past or future. The hippocampus is a region known for supporting mental time travel and organizing information along its longitudinal axis, transitioning from detailed posterior representations to generalized anterior ones. This study investigates the role of the hippocampus in distinguishing goals over time: whether the hippocampus encodes time regardless of detail or abstraction, and whether the hippocampus preferentially activates its anterior region for temporally distant goals (past and future) and its posterior region for immediate goals. We use a space-themed experiment with 7T functional MRI on 31 participants to examine how the hippocampus encodes the temporal distance of goals. During a simulated Mars mission, we find that the hippocampus tracks goals solely by temporal proximity. We show that past and future goals activate the left anterior hippocampus, while current goals engage the left posterior hippocampus. This suggests that the hippocampus maps goals using timestamps, extending its long axis system to include temporal goal organization. (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | R01 MH122611 United States MH NIMH NIH HHS; R01 MH123069 United States MH NIMH NIH HHS |
| تواريخ الأحداث: | Date Created: 20240606 Date Completed: 20240606 Latest Revision: 20240610 |
| رمز التحديث: | 20240610 |
| مُعرف محوري في PubMed: | PMC11156658 |
| DOI: | 10.1038/s41467-024-48648-9 |
| PMID: | 38844456 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2041-1723 |
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| DOI: | 10.1038/s41467-024-48648-9 |