دورية أكاديمية
Surveillance of vancomycin-resistant enterococci reveals shift in dominating clusters from vanA to vanB Enterococcus faecium clusters, Denmark, 2015 to 2022.
| العنوان: | Surveillance of vancomycin-resistant enterococci reveals shift in dominating clusters from vanA to vanB Enterococcus faecium clusters, Denmark, 2015 to 2022. |
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| المؤلفون: | Hammerum AM; Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.; These authors contributed equally to this work and share first authorship., Karstensen KT; Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.; These authors contributed equally to this work and share first authorship., Roer L; Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark., Kaya H; Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark., Lindegaard M; Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark., Porsbo LJ; Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark., Kjerulf A; Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark., Pinholt M; Department of Clinical Microbiology, Copenhagen University Hospital - Amager and Hvidovre, Denmark., Holzknecht BJ; Department of Clinical Microbiology, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Worning P; Department of Clinical Microbiology, Copenhagen University Hospital - Amager and Hvidovre, Denmark., Nielsen KL; Department of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Hansen SGK; Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark., Clausen M; Department of Clinical Microbiology, Slagelse University Hospital, Slagelse, Denmark., Søndergaard TS; Department of Clinical Microbiology, Sønderjylland Hospital, Aabenraa, Denmark., Dzajic E; Department of Clinical Microbiology, Hospital South West Jutland, Esbjerg, Denmark., Østergaard C; Department of Clinical Microbiology, Lillebaelt Hospital, Vejle, Denmark., Wang M; Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark., Koch K; Department of Clinical Microbiology, Aalborg University Hospital, Aalborg, Denmark., Hasman H; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. |
| المصدر: | Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [Euro Surveill] 2024 Jun; Vol. 29 (23). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: European Centre for Disease Prevention and Control (ECDC) Country of Publication: Sweden NLM ID: 100887452 Publication Model: Print Cited Medium: Internet ISSN: 1560-7917 (Electronic) Linking ISSN: 1025496X NLM ISO Abbreviation: Euro Surveill Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Stockholm, Sweden : European Centre for Disease Prevention and Control (ECDC) Original Publication: Saint-Maurice : Hôpital national de Saint-Maurice |
| مواضيع طبية MeSH: | Vancomycin-Resistant Enterococci*/genetics , Vancomycin-Resistant Enterococci*/isolation & purification , Vancomycin-Resistant Enterococci*/drug effects , Enterococcus faecium*/genetics , Enterococcus faecium*/drug effects , Enterococcus faecium*/isolation & purification , Gram-Positive Bacterial Infections*/microbiology , Gram-Positive Bacterial Infections*/epidemiology , Gram-Positive Bacterial Infections*/drug therapy , Anti-Bacterial Agents*/pharmacology , Bacterial Proteins*/genetics , Carbon-Oxygen Ligases*/genetics , Linezolid*/pharmacology , Multilocus Sequence Typing* , Microbial Sensitivity Tests* , Vancomycin Resistance*/genetics, Humans ; Denmark/epidemiology ; Whole Genome Sequencing ; Vancomycin/pharmacology ; Vancomycin/therapeutic use ; Genotype |
| مستخلص: | BackgroundVancomycin-resistant enterococci (VRE) are increasing in Denmark and Europe. Linezolid and vancomycin-resistant enterococci (LVRE) are of concern, as treatment options are limited. Vancomycin-variable enterococci (VVE) harbour the vanA gene complex but are phenotypically vancomycin-susceptible.AimThe aim was to describe clonal shifts for VRE and VVE in Denmark between 2015 and 2022 and to investigate genotypic linezolid resistance among the VRE and VVE.MethodsFrom 2015 to 2022, 4,090 Danish clinical VRE and VVE isolates were whole genome sequenced. We extracted vancomycin resistance genes and sequence types (STs) from the sequencing data and performed core genome multilocus sequence typing (cgMLST) analysis for Enterococcus faecium . All isolates were tested for the presence of mutations or genes encoding linezolid resistance.ResultsIn total 99% of the VRE and VVE isolates were E. faecium. From 2015 through 2019, 91.1% of the VRE and VVE were vanA E. faecium . During 2020, to the number of vanB E. faecium increased to 254 of 509 VRE and VVE isolates. Between 2015 and 2022, seven E. faecium clusters dominated: ST80-CT14 vanA , ST117-CT24 vanA , ST203-CT859 vanA, ST1421-CT1134 vanA (VVE cluster) , ST80-CT1064 vanA/vanB , ST117-CT36 vanB and ST80-CT2406 vanB. We detected 35 linezolid vancomycin-resistant E. faecium and eight linezolid-resistant VVEfm.ConclusionFrom 2015 to 2022, the numbers of VRE and VVE increased. The spread of the VVE cluster ST1421-CT1134 vanA E. faecium in Denmark is a concern, especially since VVE diagnostics are challenging. The finding of LVRE, although in small numbers, ia also a concern, as treatment options are limited. |
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| فهرسة مساهمة: | Keywords: , Enterococcus faecium; Enterococcus faecalis; LRE; LVRE; MLST; VRE; WGS; cgMLST |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Bacterial Proteins) EC 6.1.- (Carbon-Oxygen Ligases) 0 (VanA ligase, Bacteria) ISQ9I6J12J (Linezolid) 0 (VanB protein, Enterococcus) 6Q205EH1VU (Vancomycin) |
| تواريخ الأحداث: | Date Created: 20240607 Date Completed: 20240607 Latest Revision: 20240611 |
| رمز التحديث: | 20240611 |
| مُعرف محوري في PubMed: | PMC11158013 |
| DOI: | 10.2807/1560-7917.ES.2024.29.23.2300633 |
| PMID: | 38847117 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1560-7917 |
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| DOI: | 10.2807/1560-7917.ES.2024.29.23.2300633 |