دورية أكاديمية
Intensive triamcinolone acetonide injection regimen can highly prevent stricture after extensive esophageal endoscopic submucosal dissection.
| العنوان: | Intensive triamcinolone acetonide injection regimen can highly prevent stricture after extensive esophageal endoscopic submucosal dissection. |
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| المؤلفون: | Okimoto K; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan., Matsumura T; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan., Akizue N; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan., Takahashi S; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan., Horio R; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan., Goto C; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan., Kurosugi A; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan., Sonoda M; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan., Kaneko T; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan., Ohta Y; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan., Taida T; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan., Saito K; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan., Matsusaka K; Department of Pathology, Chiba University Hospital, Chiba, Japan., Kato J; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan., Ikeda JI; Department of Pathology, Chiba University Hospital, Chiba, Japan.; Department of Diagnostic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan., Kato N; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan. |
| المصدر: | Scandinavian journal of gastroenterology [Scand J Gastroenterol] 2024 Aug; Vol. 59 (8), pp. 996-1001. Date of Electronic Publication: 2024 Jun 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 0060105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1502-7708 (Electronic) Linking ISSN: 00365521 NLM ISO Abbreviation: Scand J Gastroenterol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Oslo : Universitetsforlager |
| مواضيع طبية MeSH: | Triamcinolone Acetonide*/administration & dosage , Endoscopic Mucosal Resection*/adverse effects , Esophageal Neoplasms*/surgery , Esophageal Stenosis*/prevention & control , Esophageal Stenosis*/etiology, Humans ; Male ; Female ; Retrospective Studies ; Aged ; Middle Aged ; Aged, 80 and over ; Esophagoscopy ; Postoperative Complications/prevention & control ; Treatment Outcome ; Glucocorticoids/administration & dosage ; Dilatation/methods |
| مستخلص: | Background: This study aimed to investigate the utility of intensive triamcinolone acetonide (TA) injections after extensive esophageal endoscopic submucosal dissection (ESD). Methods: This retrospective study included 27 lesions in 27 consecutive patients who underwent ESD (ulcers encompassing ≥3/4 of the esophageal circumference) and received TA injections without oral steroid administration. Groups A and B included patients undergoing ESD with and without complete circumferential resection, respectively. All patients received TA injections (100 mg/session) immediately after ESD. In Group A, weekly based TA injections were performed until near-complete ulcer epithelialization. In Group B, patients did not receive additional injections or received weekly or biweekly TA injections. The primary outcome was stricture rate, and the secondary outcomes were the proportion of patients requiring endoscopic balloon dilation (EBD) and the number of TA injections. Results: Group A included 7 lesions, and Group B included 20 lesions. The median (range) tumor lengths were 40 (30-90) and 45 (30-110) mm in Groups A and B, respectively. In Group A, the median circumferential resection diameter was 40 (20-80) mm. The stricture rate and the proportion of patients requiring EBD were 0 (0%) in Group A and 1 (5.0%) in Group B. The number of TA injection sessions was significantly higher in Group A than in Group B (8 [5-25] vs 1.5 [1-3]; p < 0.001). Conclusions: Intensive weekly or biweekly based TA injections might aid in preventing post-ESD stricture and the need for EBD in patients undergoing extensive resection involving the entire esophageal circumference. |
| فهرسة مساهمة: | Keywords: Esophagus; endoscopic submucosal dissection; injection; stricture; triamcinolone |
| المشرفين على المادة: | F446C597KA (Triamcinolone Acetonide) 0 (Glucocorticoids) |
| تواريخ الأحداث: | Date Created: 20240607 Date Completed: 20240729 Latest Revision: 20240729 |
| رمز التحديث: | 20240729 |
| DOI: | 10.1080/00365521.2024.2360557 |
| PMID: | 38847135 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1502-7708 |
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| DOI: | 10.1080/00365521.2024.2360557 |