دورية أكاديمية
أعرض في EDS

Grape seed extract prevents oestrogen deficiency-induced bone loss by modulating the gut microbiota and metabolites.

التفاصيل البيبلوغرافية
العنوان: Grape seed extract prevents oestrogen deficiency-induced bone loss by modulating the gut microbiota and metabolites.
المؤلفون: Lu L; Division of Internal Medicine, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, China., Li J; Division of Infectious Diseases, State Key Laboratory of Biotherapy and Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China., Liu L; Laboratory of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China., Wang C; Laboratory of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China., Xie Y; Laboratory of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China., Yu X; Laboratory of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China., Tian L; Laboratory of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.
المصدر: Microbial biotechnology [Microb Biotechnol] 2024 Jun; Vol. 17 (6), pp. e14485.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 101316335 Publication Model: Print Cited Medium: Internet ISSN: 1751-7915 (Electronic) Linking ISSN: 17517915 NLM ISO Abbreviation: Microb Biotechnol Subsets: MEDLINE
أسماء مطبوعة: Publication: Hoboken, NJ : Wiley-Blackwell
Original Publication: Oxford : Blackwell, c2008-
مواضيع طبية MeSH: Gastrointestinal Microbiome*/drug effects , Grape Seed Extract*/pharmacology , Estrogens*/deficiency , Estrogens*/metabolism, Animals ; Mice ; Female ; Lipid Metabolism/drug effects ; Dysbiosis/prevention & control ; Mice, Inbred C57BL ; Bacteria/metabolism ; Bacteria/classification ; Bacteria/drug effects ; Bacteria/genetics ; Osteoporosis/prevention & control ; Disease Models, Animal ; Adipose Tissue/metabolism ; Ovariectomy
مستخلص: Proanthocyanidin-rich grape seed extract (GSE) has been shown to have the potential to protect bones, although the underlying mechanism remains unknown. The current study aims to explore GSE's preventive and therapeutic impact on bone loss induced by oestrogen deficiency and the underlying mechanism through the gut microbiota (GM) and metabolomic responses. In oestrogen-deficient ovariectomized (OVX) mice, GSE ameliorated bone loss by inhibiting the expansion of bone marrow adipose tissue (BMAT), restoring BMAT lipolysis and promoting bone formation. GSE regulated OVX-induced GM dysbiosis by reducing the abundance of opportunistic pathogenic bacteria, such as Alistipes, Turicibacter and Romboutsia, while elevating the abundance of beneficial bacteria, such as Bifidobacterium. The modified GM primarily impacted lipid and amino acid metabolism. Furthermore, the serum metabolites of GSE exhibited a significant enrichment in lipid metabolism. In summary, GSE shows potential as a functional food for preventing oestrogen deficiency-induced bone loss by modulating GM and metabolite-mediated lipid metabolism.
(© 2024 The Author(s). Microbial Biotechnology published by John Wiley & Sons Ltd.)
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معلومات مُعتمدة: 82204847 National Natural Science Foundation of China; 2023YFS0332 Science and Technology Department of Sichuan Province
المشرفين على المادة: 0 (Grape Seed Extract)
0 (Estrogens)
تواريخ الأحداث: Date Created: 20240608 Date Completed: 20240608 Latest Revision: 20240610
رمز التحديث: 20240610
مُعرف محوري في PubMed: PMC11162104
DOI: 10.1111/1751-7915.14485
PMID: 38850270
قاعدة البيانات: MEDLINE
الوصف
تدمد:1751-7915
DOI:10.1111/1751-7915.14485