دورية أكاديمية
GluN2A- and GluN2B-containing pre-synaptic N -methyl-d-aspartate receptors differentially regulate action potential-evoked Ca 2+ influx via modulation of SK channels.
| العنوان: | GluN2A- and GluN2B-containing pre-synaptic N -methyl-d-aspartate receptors differentially regulate action potential-evoked Ca 2+ influx via modulation of SK channels. |
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| المؤلفون: | Schmidt CC; Department of Pharmacology, University of Oxford , Oxford OX1 3QT, UK., Tong R; Department of Pharmacology, University of Oxford , Oxford OX1 3QT, UK.; Montreal Neurological Institute, 3801 University Street , Montreal, Quebec H3A 2B4, Canada., Emptage NJ; Department of Pharmacology, University of Oxford , Oxford OX1 3QT, UK. |
| المصدر: | Philosophical transactions of the Royal Society of London. Series B, Biological sciences [Philos Trans R Soc Lond B Biol Sci] 2024 Jul 29; Vol. 379 (1906), pp. 20230222. Date of Electronic Publication: 2024 Jun 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society Country of Publication: England NLM ID: 7503623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-2970 (Electronic) Linking ISSN: 09628436 NLM ISO Abbreviation: Philos Trans R Soc Lond B Biol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Royal Society, 1934- |
| مواضيع طبية MeSH: | Receptors, N-Methyl-D-Aspartate*/metabolism , Small-Conductance Calcium-Activated Potassium Channels*/metabolism , Action Potentials*/physiology , Calcium*/metabolism, Animals ; Rats ; Synapses/physiology ; Synapses/metabolism ; Neuronal Plasticity/physiology ; Pyramidal Cells/physiology ; Pyramidal Cells/metabolism |
| مستخلص: | N -methyl-d-aspartate receptors (NMDARs) play a pivotal role in synaptic plasticity. While the functional role of post-synaptic NMDARs is well established, pre-synaptic NMDAR (pre-NMDAR) function is largely unexplored. Different pre-NMDAR subunit populations are documented at synapses, suggesting that subunit composition influences neuronal transmission. Here, we used electrophysiological recordings at Schaffer collateral-CA1 synapses partnered with Ca 2+ imaging and glutamate uncaging at boutons of CA3 pyramidal neurones to reveal two populations of pre-NMDARs that contain either the GluN2A or GluN2B subunit. Activation of the GluN2B population decreases action potential-evoked Ca 2+ influx via modulation of small-conductance Ca 2+ -activated K+ channels, while activation of the GluN2A population does the opposite. Critically, the level of functional expression of the subunits is subject to homeostatic regulation, bidirectionally affecting short-term facilitation, thus providing a capacity for a fine adjustment of information transfer. This article is part of a discussion meeting issue 'Long-term potentiation: 50 years on'. |
| معلومات مُعتمدة: | Clarendon Fund; United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: NMDA receptor; SK channel; homeostatic plasticity; pre-synaptic terminal; short-term plasticity |
| المشرفين على المادة: | 0 (Receptors, N-Methyl-D-Aspartate) 0 (NR2B NMDA receptor) 0 (Small-Conductance Calcium-Activated Potassium Channels) VH92ICR8HX (N-methyl D-aspartate receptor subtype 2A) SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 20240610 Date Completed: 20240610 Latest Revision: 20240610 |
| رمز التحديث: | 20240610 |
| DOI: | 10.1098/rstb.2023.0222 |
| PMID: | 38853550 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1471-2970 |
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| DOI: | 10.1098/rstb.2023.0222 |