دورية أكاديمية
Cost-utility analysis of a flash continuous glucose monitoring system in the management of people with type 2 diabetes mellitus on basal insulin therapy-An Italian healthcare system perspective.
العنوان: | Cost-utility analysis of a flash continuous glucose monitoring system in the management of people with type 2 diabetes mellitus on basal insulin therapy-An Italian healthcare system perspective. |
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المؤلفون: | Del Prato S; Interdisciplinary Research Center 'Health Science' of the Sant'Anna School of Advanced Studies, Pisa, Italy., Giorgino F; Department of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, Bari, Italy., Szafranski K; Eversana, Burlington, Ontario, Canada., Poon Y; Abbott Diabetes Care, Alameda, California, USA. |
المصدر: | Diabetes, obesity & metabolism [Diabetes Obes Metab] 2024 Sep; Vol. 26 (9), pp. 3633-3641. Date of Electronic Publication: 2024 Jun 10. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883645 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1463-1326 (Electronic) Linking ISSN: 14628902 NLM ISO Abbreviation: Diabetes Obes Metab Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Oxford : Wiley-Blackwell, c1999- |
مواضيع طبية MeSH: | Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/blood , Diabetes Mellitus, Type 2*/economics , Cost-Benefit Analysis* , Blood Glucose Self-Monitoring*/economics , Blood Glucose Self-Monitoring*/instrumentation , Blood Glucose Self-Monitoring*/methods , Quality-Adjusted Life Years* , Hypoglycemic Agents*/therapeutic use , Hypoglycemic Agents*/economics, Humans ; Italy ; Female ; Male ; Middle Aged ; Insulin/therapeutic use ; Insulin/economics ; Insulin/administration & dosage ; Blood Glucose/analysis ; Blood Glucose/metabolism ; Aged ; Glycated Hemoglobin/analysis ; Glycated Hemoglobin/metabolism ; Hypoglycemia/chemically induced ; Hypoglycemia/economics ; Hypoglycemia/prevention & control ; Continuous Glucose Monitoring |
مستخلص: | Aims: To assess the cost-utility of the FreeStyle Libre flash continuous glucose monitoring (CGM) system from an Italian healthcare system perspective, when compared with self-monitoring of blood glucose (SMBG) in people living with type 2 diabetes mellitus (T2DM) receiving basal insulin. Materials and Methods: A patient-level microsimulation model was run using Microsoft Excel for 10 000 patients over a lifetime horizon, with 3.0% discounting for costs and utilities. Inputs were based on clinical trials and real-world evidence, with patient characteristics reflecting Italian population data. The effect of flash CGM was modelled as a persistent 0.8% reduction in glycated haemoglobin versus SMBG. Costs (€ 2023) and disutilities were applied to glucose monitoring, diabetes complications, severe hypoglycaemia, and diabetic ketoacidosis. The health outcome was measured as quality-adjusted life-years (QALYs). Results: Direct costs were €5338 higher with flash CGM than with SMBG. Flash CGM was associated with 0.51 more QALYs than SMBG, giving an incremental cost-effectiveness ratio (ICER) of €10 556/QALY. Scenario analysis ICERs ranged from €3825/QALY to €26 737/QALY. In probabilistic analysis, flash CGM was 100% likely to be cost effective at willingness-to-pay thresholds > €20 000/QALY. Conclusions: From an Italian healthcare system perspective, flash CGM is cost effective compared with SMBG for people living with T2DM on basal insulin. (© 2024 John Wiley & Sons Ltd.) |
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فهرسة مساهمة: | Keywords: basal insulin; cost‐effectiveness; glycaemic control; health economics |
المشرفين على المادة: | 0 (Hypoglycemic Agents) 0 (Insulin) 0 (Blood Glucose) 0 (Glycated Hemoglobin) |
تواريخ الأحداث: | Date Created: 20240610 Date Completed: 20240805 Latest Revision: 20240805 |
رمز التحديث: | 20240805 |
DOI: | 10.1111/dom.15703 |
PMID: | 38853717 |
قاعدة البيانات: | MEDLINE |
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