دورية أكاديمية
Design and synthesis of novel β-carboline-bisindole hybrids as potential anticancer agents.
| العنوان: | Design and synthesis of novel β-carboline-bisindole hybrids as potential anticancer agents. |
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| المؤلفون: | Dang TT; Vietnam National University, Chemistry, 19 Le Thanh Tong Street, 100000, Hanoi, VIET NAM., Huyen NTT; Vietnam National University Hanoi, chemistry, VIET NAM., Phuc BV; Vietnam Academy of Science and Technology, chemistry, VIET NAM., Huyen TT; Vietnam National University, chemistry, 19 Le Thanh Tong Street, Hanoi, 100000, Hanoi, VIET NAM., Hong TT; Vietnam National University, chemistry, VIET NAM., Nguyen H; Hanoi National University of Education, chemistry, VIET NAM., Nguyen VH; Vietnam National University, chemistry, VIET NAM., Nguyen MT; KU Leuven, chemistry, BELGIUM., Hung TQ; Vietnam Academy of Science and Technology, chemistry, VIET NAM., Dinh CP; NuChem Therapeutics, chemistry, CANADA. |
| المصدر: | ChemMedChem [ChemMedChem] 2024 Jun 10, pp. e202400316. Date of Electronic Publication: 2024 Jun 10. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Weinheim, Germany : Wiley-VCH, c2006- |
| مستخلص: | We are reporting a short and convenient pathway for the synthesis of novel β-carboline-bisindole hybrid compounds from relatively cheap and commercially available chemicals such as tryptamine, dialdehydes and indoles. These newly designed compounds can also be prepared in high yields with the tolerance of many functional groups under mild conditions. Notably, these β-carboline-bisindole hybrid compounds exhibited some promising applications as anticancer agents against the three common cancer cell lines MCF-7 (breast cancer), SK-LU-1 (lung cancer), and HepG2 (liver cancer). The two best compounds 5b and 5g inhibited the aforementioned cell lines with the same range of the reference Ellipticine at less than 2 µM. A molecular docking study to gain more information about the interactions between the synthesized molecules and the kinase domain of the EGFR was performed. Therefore, this finding can have significant impacts on the development of future research in medicinal chemistry and drug discovery. (© 2024 Wiley‐VCH GmbH.) |
| فهرسة مساهمة: | Keywords: anticancer agents , antiproliferative activity, bis(3-indolyl)methanes, β-carbolines, molecular docking |
| تواريخ الأحداث: | Date Created: 20240610 Latest Revision: 20240610 |
| رمز التحديث: | 20240610 |
| DOI: | 10.1002/cmdc.202400316 |
| PMID: | 38856518 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1860-7187 |
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| DOI: | 10.1002/cmdc.202400316 |