دورية أكاديمية
Design and Synthesis of Novel β-Carboline-Bisindole Hybrids as Potential Anticancer Agents.
| العنوان: | Design and Synthesis of Novel β-Carboline-Bisindole Hybrids as Potential Anticancer Agents. |
|---|---|
| المؤلفون: | Huyen NTT; Faculty of Chemistry, VNU-Ha Noi University of Science, 19 Le Thanh Tong, Phan Chu Trinh, Hoan Kiem, Hanoi, Vietnam., Phuc BV; Institute of Chemistry, Vietnamese Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Hanoi, Vietnam., Huyen TT; Faculty of Chemistry, VNU-Ha Noi University of Science, 19 Le Thanh Tong, Phan Chu Trinh, Hoan Kiem, Hanoi, Vietnam., Hong TT; Faculty of Chemistry, VNU-Ha Noi University of Science, 19 Le Thanh Tong, Phan Chu Trinh, Hoan Kiem, Hanoi, Vietnam., Nguyen H; Faculty of Chemistry, Hanoi National University of Education (HNUE), Vietnam., Nguyen VH; Faculty of Chemistry, VNU-Ha Noi University of Science, 19 Le Thanh Tong, Phan Chu Trinh, Hoan Kiem, Hanoi, Vietnam., Nguyen MT; Faculty of Applied Technology, School of Technology, Van Lang University, Ho Chi Minh City, 70000, Vietnam., Hung TQ; Institute of Chemistry, Vietnamese Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Hanoi, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Vietnam., Dinh CP; NuChem Sciences, a Sygnature Discovery Business, 480 rue Perreault, Lévis, QC, G6 W 7 V6, Canada., Dang TT; Faculty of Chemistry, VNU-Ha Noi University of Science, 19 Le Thanh Tong, Phan Chu Trinh, Hoan Kiem, Hanoi, Vietnam. |
| المصدر: | ChemMedChem [ChemMedChem] 2024 Jun 10, pp. e202400316. Date of Electronic Publication: 2024 Jun 10. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Weinheim, Germany : Wiley-VCH, c2006- |
| مستخلص: | We are reporting a short and convenient pathway for the synthesis of novel β-carboline-bisindole hybrid compounds from relatively cheap and commercially available chemicals such as tryptamine, dialdehydes and indoles. These newly designed compounds can also be prepared in high yields with the tolerance of many functional groups under mild conditions. Notably, these β-carboline-bisindole hybrid compounds exhibited some promising applications as anticancer agents against the three common cancer cell lines MCF-7 (breast cancer), SK-LU-1 (lung cancer), and HepG2 (liver cancer). The two best compounds 5 b and 5 g inhibited the aforementioned cell lines with the same IC (© 2024 Wiley-VCH GmbH.) |
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| معلومات مُعتمدة: | Vingroup Joint Stock Company; VINIF.2021.DA00203 Vingroup Innovation Foundation (VINIF) |
| فهرسة مساهمة: | Keywords: anticancer agents; antiproliferative activity; bis(3-indolyl)methanes; molecular docking; β-carbolines |
| تواريخ الأحداث: | Date Created: 20240610 Latest Revision: 20240808 |
| رمز التحديث: | 20240808 |
| DOI: | 10.1002/cmdc.202400316 |
| PMID: | 38856518 |
| قاعدة البيانات: | MEDLINE |
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