دورية أكاديمية
Plasma Extracellular MicroRNAs Associated With Cardiovascular Disease Risk Factors in Middle-Aged and Older Adults.
| العنوان: | Plasma Extracellular MicroRNAs Associated With Cardiovascular Disease Risk Factors in Middle-Aged and Older Adults. |
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| المؤلفون: | Karlin H; Framingham Heart Study Framingham MA USA.; Population Sciences Branch National Heart, Lung, and Blood Institute Bethesda MD USA., Sooda M; Framingham Heart Study Framingham MA USA.; Population Sciences Branch National Heart, Lung, and Blood Institute Bethesda MD USA., Larson M; Framingham Heart Study Framingham MA USA.; Department of Biostatistics Boston University School of Public Health Boston MA USA., Rong J; Framingham Heart Study Framingham MA USA.; Department of Neurology Boston University Chobanian & Avedisian School of Medicine Boston MA USA., Huan T; Framingham Heart Study Framingham MA USA.; Population Sciences Branch National Heart, Lung, and Blood Institute Bethesda MD USA.; Ophthalmology and Visual Sciences University of Massachusetts Medical School Worcester MA USA., Mens MMJ; Department of Epidemiology Erasmus MC University Medical Center Rotterdam The Netherlands.; Department of Social and Behavioral Sciences Harvard T.H Chan School of Public Health Boston MA USA., van Rooij FJA; Department of Epidemiology Erasmus MC University Medical Center Rotterdam The Netherlands., Ikram MA; Department of Epidemiology Erasmus MC University Medical Center Rotterdam The Netherlands., Courchesne P; Framingham Heart Study Framingham MA USA.; Population Sciences Branch National Heart, Lung, and Blood Institute Bethesda MD USA., Freedman JE; Department of Medicine, Division of Cardiovascular Medicine Vanderbilt University Medical Center Nashville TN USA., Joehanes R; Framingham Heart Study Framingham MA USA.; Population Sciences Branch National Heart, Lung, and Blood Institute Bethesda MD USA., Mueller GP; Department of Anatomy, Physiology, and Genetics, F. Edward Hebert School of Medicine Uniformed Services University of the Health Sciences Bethesda MD USA., Kavousi M; Department of Epidemiology Erasmus MC University Medical Center Rotterdam The Netherlands., Ghanbari M; Department of Epidemiology Erasmus MC University Medical Center Rotterdam The Netherlands., Levy D; Framingham Heart Study Framingham MA USA.; Population Sciences Branch National Heart, Lung, and Blood Institute Bethesda MD USA.; Boston University School of Medicine Boston MA USA. |
| المصدر: | Journal of the American Heart Association [J Am Heart Assoc] 2024 Jun 18; Vol. 13 (12), pp. e033674. Date of Electronic Publication: 2024 Jun 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Wiley-Blackwell |
| مواضيع طبية MeSH: | Cardiovascular Diseases*/genetics , Cardiovascular Diseases*/blood , Cardiovascular Diseases*/mortality , MicroRNAs*/blood , MicroRNAs*/genetics , Heart Disease Risk Factors*, Humans ; Male ; Female ; Middle Aged ; Aged ; Prospective Studies ; Cross-Sectional Studies ; Risk Assessment ; Circulating MicroRNA/blood ; Circulating MicroRNA/genetics ; Risk Factors ; Biomarkers/blood ; Age Factors |
| مستخلص: | Background: Extracellular microRNAs (miRNAs) are a class of noncoding RNAs that remain stable in the extracellular milieu, where they contribute to various physiological and pathological processes by facilitating intercellular signaling. Previous studies have reported associations between miRNAs and cardiovascular diseases (CVDs); however, the plasma miRNA signatures of CVD and its risk factors have not been fully elucidated at the population level. Methods and Results: Plasma miRNA levels were measured in 4440 FHS (Framingham Heart Study) participants. Linear regression analyses were conducted to test the cross-sectional associations of each miRNA with 8 CVD risk factors. Prospective analyses of the associations of miRNAs with new-onset obesity, hypertension, type 2 diabetes, CVD, and all-cause mortality were conducted using proportional hazards regression. Replication was carried out in 1999 RS (Rotterdam Study) participants. Pathway enrichment analyses were conducted and target genes were predicted for miRNAs associated with ≥5 risk factors in the FHS. In the FHS, 6 miRNAs (miR-193b-3p, miR-122-5p, miR-365a-3p, miR-194-5p, miR-192-5p, and miR-193a-5p) were associated with ≥5 risk factors. This miRNA signature was enriched for pathways associated with CVD and several genes annotated to these pathways were predicted targets of the identified miRNAs. Furthermore, miR-193b-3p, miR-194-5p, and miR-193a-5p were each associated with ≥2 risk factors in the RS. Prospective analysis revealed 8 miRNAs associated with all-cause mortality in the FHS. Conclusions: These findings highlight associations between miRNAs and CVD risk factors that may provide valuable insights into the underlying pathogenesis of CVD. |
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| معلومات مُعتمدة: | 75N92019D00031 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: cardiovascular disease; extracellular RNA; microRNA; pathways; risk factors |
| المشرفين على المادة: | 0 (MicroRNAs) 0 (Circulating MicroRNA) 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20240611 Date Completed: 20240618 Latest Revision: 20240720 |
| رمز التحديث: | 20240720 |
| مُعرف محوري في PubMed: | PMC11255734 |
| DOI: | 10.1161/JAHA.123.033674 |
| PMID: | 38860398 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2047-9980 |
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| DOI: | 10.1161/JAHA.123.033674 |