دورية أكاديمية
M1/M2 macrophage-targeted nanotechnology and PROTAC for the treatment of atherosclerosis.
| العنوان: | M1/M2 macrophage-targeted nanotechnology and PROTAC for the treatment of atherosclerosis. |
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| المؤلفون: | Ma Y; School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China; School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China., Yang X; School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China; School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China., Ning K; School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China; School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China. Electronic address: ningke@shutcm.edu.cn., Guo H; School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China; School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201203, China. Electronic address: hdguo@shutcm.edu.cn. |
| المصدر: | Life sciences [Life Sci] 2024 Sep 01; Vol. 352, pp. 122811. Date of Electronic Publication: 2024 Jun 09. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2008->: Amsterdam : Elsevier Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press. |
| مواضيع طبية MeSH: | Atherosclerosis*/drug therapy , Atherosclerosis*/immunology , Macrophages*/drug effects , Macrophages*/metabolism , Nanotechnology*/methods , Proteolysis*/drug effects, Humans ; Animals |
| مستخلص: | Macrophages play key roles in atherosclerosis progression, and an imbalance in M1/M2 macrophages leads to unstable plaques; therefore, M1/M2 macrophage polarization-targeted treatments may serve as a new approach in the treatment of atherosclerosis. At present, there is little research on M1/M2 macrophage polarization-targeted nanotechnology. Proteolysis-targeting chimera (PROTAC) technology, a targeted protein degradation technology, mediates the degradation of target proteins and has been widely promoted in preclinical and clinical applications as a novel therapeutic modality. This review summarizes the recent studies on M1/M2 macrophage polarization-targeted nanotechnology, focusing on the mechanism and advantages of PROTACs in M1/M2 macrophage polarization as a new approach for the treatment of atherosclerosis. Competing Interests: Declaration of competing interest All authors declare that they have no conflict of interest. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Atherosclerosis; Macrophage; Nanotechnology; PROTAC |
| تواريخ الأحداث: | Date Created: 20240611 Date Completed: 20240727 Latest Revision: 20240727 |
| رمز التحديث: | 20240729 |
| DOI: | 10.1016/j.lfs.2024.122811 |
| PMID: | 38862062 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0631 |
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| DOI: | 10.1016/j.lfs.2024.122811 |