دورية أكاديمية
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U-shaped association between serum calcium and in-hospital mortality in diabetes patients with congestive heart failure: a cohort study.

التفاصيل البيبلوغرافية
العنوان: U-shaped association between serum calcium and in-hospital mortality in diabetes patients with congestive heart failure: a cohort study.
المؤلفون: Zhang K; Cardiovascular Surgery Department of Jilin University Second Hospital, No. 218, Ziqiang Street, Changchun, Jilin Province, China. kaizhang@vip.126.com., Zhang T; Cardiovascular Surgery Department of Jilin University Second Hospital, No. 218, Ziqiang Street, Changchun, Jilin Province, China., Lv QY; Cardiovascular Surgery Department of Jilin University Second Hospital, No. 218, Ziqiang Street, Changchun, Jilin Province, China., Han Y; Department of Ophthalmology, First Hospital of Jilin University, Changchun, China., Cai T; Department of Ophthalmology, Second Hospital of Jilin University, Changchun, China., Gu FM; Cardiovascular Surgery Department of Jilin University Second Hospital, No. 218, Ziqiang Street, Changchun, Jilin Province, China., Gu ZX; Cardiovascular Surgery Department of Jilin University Second Hospital, No. 218, Ziqiang Street, Changchun, Jilin Province, China., Zhao JY; Cardiovascular Surgery Department of Jilin University Second Hospital, No. 218, Ziqiang Street, Changchun, Jilin Province, China., Liang JY; Cardiovascular Surgery Department of Jilin University Second Hospital, No. 218, Ziqiang Street, Changchun, Jilin Province, China., Gao M; Department of Cancer Center, The First Hospital of Jilin University, Changchun, China., Gao YF; Department of Ophthalmology, Second Hospital of Jilin University, Changchun, China., Hu R; Department of Ophthalmology, Second Hospital of Jilin University, Changchun, China., Cui D; Cardiovascular Surgery Department of Jilin University Second Hospital, No. 218, Ziqiang Street, Changchun, Jilin Province, China., Li B; Cardiovascular Surgery Department of Jilin University Second Hospital, No. 218, Ziqiang Street, Changchun, Jilin Province, China., Liu K; Cardiovascular Surgery Department of Jilin University Second Hospital, No. 218, Ziqiang Street, Changchun, Jilin Province, China. kxliu64@hotmail.com.
المصدر: Scientific reports [Sci Rep] 2024 Jun 11; Vol. 14 (1), pp. 13412. Date of Electronic Publication: 2024 Jun 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Heart Failure*/mortality , Heart Failure*/blood , Hospital Mortality* , Calcium*/blood , Diabetes Mellitus*/blood , Diabetes Mellitus*/mortality, Humans ; Female ; Male ; Aged ; Middle Aged ; Retrospective Studies ; Aged, 80 and over
مستخلص: Previous studies have reported that the significant association between serum calcium and mortality substantially in patients, especially among those with intensive care unit (ICU). And In diabetes mellitus, congestive heart failure (CHF) is a significant comorbidity. We aim to evaluate the association between serum calcium levels and in-hospital mortality among patients with diabetes and congestive heart failure. The participants in this study were extracted from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. To scrutinize potential associations between serum calcium levels and in-hospital mortality, a comprehensive analysis encompassing multivariate logistic regression, cubic spline function model, threshold effect analysis, and subgroup analysis was performed. This retrospective cohort study encompassed 7063 patients, among whom the in-hospital mortality stood at 12.2%. In the multivariate logistic regression, adjusted odds ratios (ORs) were contrasted with the reference category Q6 (8.8-9.1 mg/dL) for serum calcium levels and in-hospital mortality. The adjusted ORs for Q1 (≤ 7.7 mg/dL), Q2 (7.7-8 mg/dL), and Q7 (≥ 9.1 mg/dL) were 1.69 (95% CI 1.17-2.44, p = 0.005), 1.62 (95% CI 1.11-2.36, p = 0.013), and 1.57 (95% CI 1.1-2.24, p = 0.012) respectively. The dose-response analysis uncovered a U-shaped relationship between serum calcium levels and in-hospital mortality in diabetic patients with heart failure. Subgroup analyses confirmed result stability notwithstanding the influence of diverse factors. Our investigation revealed a U-shaped correlation between serum calcium levels and in-hospital mortality in diabetes patients with congestive heart failure, pinpointing a significant inflection point at 9.05 mg/dL.
(© 2024. The Author(s).)
References: J Am Coll Cardiol. 2004 May 5;43(9):1663-9. (PMID: 15120828)
Ann Nutr Metab. 2018;72(2):87-95. (PMID: 29346788)
Circ Res. 2015 Jan 2;116(1):e1-e10. (PMID: 25348166)
Sci Data. 2023 Jan 3;10(1):1. (PMID: 36596836)
South Med J. 2005 Oct;98(10):1024-7. (PMID: 16295817)
Circ Heart Fail. 2016 Jan;9(1):. (PMID: 26754626)
Eur Heart J. 2008 Jun;29(11):1377-85. (PMID: 18413309)
Eur J Epidemiol. 2013 Jul;28(7):569-78. (PMID: 23860708)
J Clin Endocrinol Metab. 2007 Jun;92(6):2017-29. (PMID: 17389701)
JACC Cardiovasc Imaging. 2018 Jan;11(1):127-142. (PMID: 29301708)
Front Pharmacol. 2021 Apr 20;12:632375. (PMID: 34177568)
Front Genet. 2019 Oct 23;10:1069. (PMID: 31708976)
Lancet. 2015 May 23;385(9982):2107-17. (PMID: 26009231)
Int J Mol Sci. 2021 Sep 30;22(19):. (PMID: 34638917)
Diabet Med. 2023 Aug;40(8):e15080. (PMID: 36883871)
Am J Hum Genet. 2016 Nov 3;99(5):1034-1044. (PMID: 27745835)
Front Pharmacol. 2022 Jun 13;13:869499. (PMID: 35770093)
Compr Physiol. 2016 Sep 15;6(4):1781-1800. (PMID: 27783859)
Heart Fail Rev. 2020 Jan;25(1):53-65. (PMID: 31332663)
Osteoporos Int. 2016 May;27(5):1747-54. (PMID: 26659066)
Nutrients. 2019 Aug 22;11(9):. (PMID: 31443528)
Mol Cell Biochem. 1998 Nov;188(1-2):129-36. (PMID: 9823018)
Cardiovasc Diabetol. 2016 Oct 3;15(1):140. (PMID: 27716206)
J Diabetes. 2022 Feb;14(2):121-133. (PMID: 34963041)
Front Cardiovasc Med. 2021 Nov 12;8:753133. (PMID: 34869661)
Eur J Heart Fail. 2002 Mar;4(2):167-73. (PMID: 11959045)
Medicina (Kaunas). 2020 Mar 02;56(3):. (PMID: 32131462)
Hypertension. 2019 May;73(5):e35-e66. (PMID: 30827125)
Endocrine. 2017 Aug;57(2):344-351. (PMID: 28667379)
Diabetologia. 2014 Jul;57(7):1366-74. (PMID: 24763850)
J Cardiovasc Dev Dis. 2022 Oct 02;9(10):. (PMID: 36286286)
Am J Clin Nutr. 2016 Oct;104(4):1023-1029. (PMID: 27510541)
Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1763-9. (PMID: 24925973)
Am J Med. 2019 Feb;132(2):200-208.e1. (PMID: 30691552)
Eur J Heart Fail. 2013 Feb;15(2):194-202. (PMID: 23059198)
Nutrients. 2023 Feb 02;15(3):. (PMID: 36771474)
BMJ. 2016 Jul 12;354:i3477. (PMID: 27413012)
Nat Rev Endocrinol. 2016 Oct;12(10):616-22. (PMID: 27388988)
Clin Chim Acta. 2011 Apr 11;412(9-10):696-701. (PMID: 21238441)
Semin Cell Dev Biol. 2020 Jul;103:20-30. (PMID: 32085965)
Lancet Diabetes Endocrinol. 2014 Oct;2(10):843-51. (PMID: 24731668)
فهرسة مساهمة: Keywords: Association; Blood calcium; Cubic spline function model; Diabetes; In-hospital mortality; Subgroup analysis
المشرفين على المادة: SY7Q814VUP (Calcium)
تواريخ الأحداث: Date Created: 20240611 Date Completed: 20240611 Latest Revision: 20240614
رمز التحديث: 20240614
مُعرف محوري في PubMed: PMC11167038
DOI: 10.1038/s41598-024-63603-w
PMID: 38862553
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-63603-w