دورية أكاديمية
أعرض في EDS

Bio-guided isolation of a new sesquiterpene from Artemisia cina with anthelmintic activity against Haemonchus contortus L3 infective larvae.

التفاصيل البيبلوغرافية
العنوان: Bio-guided isolation of a new sesquiterpene from Artemisia cina with anthelmintic activity against Haemonchus contortus L3 infective larvae.
المؤلفون: Arango-De la Pava LD; Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Cuautitlán, Estado de México, México., González-Cortázar M; Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Xochitepec, Morelos, México., Zamilpa A; Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Xochitepec, Morelos, México., Cuéllar-Ordaz JA; Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Cuautitlán, Estado de México, México., de la Cruz-Cruz HA; Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Cuautitlán, Estado de México, México., Higuera-Piedrahita RI; Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Xochitepec, Morelos, México., López-Arellano R; Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Xochitepec, Morelos, México.
المصدر: PloS one [PLoS One] 2024 Jun 12; Vol. 19 (6), pp. e0305155. Date of Electronic Publication: 2024 Jun 12 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Artemisia*/chemistry , Haemonchus*/drug effects , Anthelmintics*/pharmacology , Anthelmintics*/isolation & purification , Anthelmintics*/chemistry , Larva*/drug effects , Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Sesquiterpenes*/pharmacology , Sesquiterpenes*/chemistry , Sesquiterpenes*/isolation & purification, Animals ; Sheep ; Magnetic Resonance Spectroscopy
مستخلص: Haemonchus contortus is a blood-feeding gastrointestinal parasite that impacts grazing sheep, causing economic losses in animal production. Due to its anthelmintic resistance, alternative antiparasitic treatments like plant-based anthelmintics are necessary to explore. Artemisia cina (Asteraceae) is a plant whose n-hexane extract and ethyl acetate extract exhibit anthelmintic activity against H. contortus, the n-hexane more active. To discover additional bioactive metabolites, a chemical analysis was performed on ethyl acetate extract, which presented an LC90 of 3.30 mg/mL and allowed the isolation of 11-[(1R,5S,7R,8R,10S,)-1,8-dihydroxy-5,10-dimethyl-4-oxodecahydroazulen-7-yl] acrylic acid. This new sesquiterpene was identified through one and two-dimensional NMR. The compound was named cinic acid and displayed an LC50 of 0.13 (0.11-0.14) mg/mL and LC90 of 0.40 (0.37-0.44) mg/mL, which, compared with ethyl acetate extract larvicidal activity, was 256-fold more active at LC50 and 15.71-fold at LC90. In this study, a new sesquiterpene with larvicidal activity against H. contortus L3 infective larvae was isolated from the ethyl acetate extract of Artemisia cina.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Arango-De la Pava et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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المشرفين على المادة: 0 (Anthelmintics)
0 (Plant Extracts)
0 (Sesquiterpenes)
تواريخ الأحداث: Date Created: 20240612 Date Completed: 20240612 Latest Revision: 20240614
رمز التحديث: 20240614
مُعرف محوري في PubMed: PMC11168668
DOI: 10.1371/journal.pone.0305155
PMID: 38865346
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0305155