دورية أكاديمية
أعرض في EDS

Induction and antiviral activity of ferret myxovirus resistance (Mx) protein 1 against influenza A viruses.

التفاصيل البيبلوغرافية
العنوان: Induction and antiviral activity of ferret myxovirus resistance (Mx) protein 1 against influenza A viruses.
المؤلفون: Farrukee R; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, 792 Elizabeth St., Victoria, 3000, Australia., Schwab LSU; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, 792 Elizabeth St., Victoria, 3000, Australia.; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, 53127, Bonn, Germany., Barnes JB; Victorian Infectious Diseases Reference Laboratory, WHO Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St., Victoria, 3000, Australia., Brooks AG; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, 792 Elizabeth St., Victoria, 3000, Australia., Londrigan SL; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, 792 Elizabeth St., Victoria, 3000, Australia., Hartmann G; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, 53127, Bonn, Germany., Zillinger T; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, 53127, Bonn, Germany., Reading PC; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, 792 Elizabeth St., Victoria, 3000, Australia. preading@unimelb.edu.au.; Victorian Infectious Diseases Reference Laboratory, WHO Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St., Victoria, 3000, Australia. preading@unimelb.edu.au.
المصدر: Scientific reports [Sci Rep] 2024 Jun 12; Vol. 14 (1), pp. 13524. Date of Electronic Publication: 2024 Jun 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Myxovirus Resistance Proteins*/genetics , Myxovirus Resistance Proteins*/metabolism , Ferrets* , Influenza A virus*/immunology , Orthomyxoviridae Infections*/immunology , Orthomyxoviridae Infections*/virology, Animals ; Humans ; Virus Replication/drug effects ; Antiviral Agents/pharmacology ; Cell Line ; Mice ; Immunity, Innate ; Lung/virology ; Lung/immunology
مستخلص: Myxovirus resistance (Mx) proteins are products of interferon stimulated genes (ISGs) and Mx proteins of different species have been reported to mediate antiviral activity against a number of viruses, including influenza A viruses (IAV). Ferrets are widely considered to represent the 'gold standard' small animal model for studying pathogenesis and immunity to human IAV infections, however little is known regarding the antiviral activity of ferret Mx proteins. Herein, we report induction of ferret (f)Mx1/2 in a ferret lung cell line and in airway tissues from IAV-infected ferrets, noting that fMx1 was induced to higher levels that fMx2 both in vitro and in vivo. Overexpression confirmed cytoplasmic expression of fMx1 as well as its ability to inhibit infection and replication of IAV, noting that this antiviral effect of fMx1was modest when compared to cells overexpressing either human MxA or mouse Mx1. Together, these studies provide the first insights regarding the role of fMx1 in cell innate antiviral immunity to influenza viruses. Understanding similarities and differences in the antiviral activities of human and ferret ISGs provides critical context for evaluating results when studying human IAV infections in the ferret model.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 1143154 National Health and Medical Research Council (NHMRC) of Australia; TTU 07.834_00 German Center for Infectious Diseases; 369799452-TRR237 Deutsche Forschungsgemeinschaft
المشرفين على المادة: 0 (Myxovirus Resistance Proteins)
0 (Antiviral Agents)
تواريخ الأحداث: Date Created: 20240612 Date Completed: 20240612 Latest Revision: 20240626
رمز التحديث: 20240626
مُعرف محوري في PubMed: PMC11169552
DOI: 10.1038/s41598-024-63314-2
PMID: 38866913
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-63314-2