دورية أكاديمية
أعرض في EDS

Identification of novel risk factors for postoperative severe hypocalcemia in patients with primary hyperparathyroidism undergoing parathyroidectomy: a case control study.

التفاصيل البيبلوغرافية
العنوان: Identification of novel risk factors for postoperative severe hypocalcemia in patients with primary hyperparathyroidism undergoing parathyroidectomy: a case control study.
المؤلفون: Xu J; General Surgery of Beijing Jishuitan Hospital, Capital Medical University, The Fourth Clinical Medical College of Peking University, 68 Huinanbei Road, Changping District, Beijing, 100096, China., Kong N; General Surgery of Beijing Jishuitan Hospital, Capital Medical University, The Fourth Clinical Medical College of Peking University, 68 Huinanbei Road, Changping District, Beijing, 100096, China., Bai N; General Surgery of Beijing Jishuitan Hospital, Capital Medical University, The Fourth Clinical Medical College of Peking University, 68 Huinanbei Road, Changping District, Beijing, 100096, China., Zhang Z; General Surgery of Beijing Jishuitan Hospital, Capital Medical University, The Fourth Clinical Medical College of Peking University, 68 Huinanbei Road, Changping District, Beijing, 100096, China., Cui A; General Surgery of Beijing Jishuitan Hospital, Capital Medical University, The Fourth Clinical Medical College of Peking University, 68 Huinanbei Road, Changping District, Beijing, 100096, China., Tan S; General Surgery of Beijing Jishuitan Hospital, Capital Medical University, The Fourth Clinical Medical College of Peking University, 68 Huinanbei Road, Changping District, Beijing, 100096, China., Xu Q; General Surgery of Beijing Jishuitan Hospital, Capital Medical University, The Fourth Clinical Medical College of Peking University, 68 Huinanbei Road, Changping District, Beijing, 100096, China. xuqq_pku@126.com.
المصدر: BMC endocrine disorders [BMC Endocr Disord] 2024 Jun 12; Vol. 24 (1), pp. 88. Date of Electronic Publication: 2024 Jun 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101088676 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6823 (Electronic) Linking ISSN: 14726823 NLM ISO Abbreviation: BMC Endocr Disord Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Hyperparathyroidism, Primary*/surgery , Hyperparathyroidism, Primary*/blood , Hyperparathyroidism, Primary*/complications , Parathyroidectomy*/adverse effects , Hypocalcemia*/etiology , Hypocalcemia*/blood , Hypocalcemia*/epidemiology , Hypocalcemia*/diagnosis , Postoperative Complications*/blood , Postoperative Complications*/etiology , Postoperative Complications*/epidemiology , Postoperative Complications*/diagnosis, Humans ; Female ; Male ; Middle Aged ; Risk Factors ; Retrospective Studies ; Case-Control Studies ; Aged ; Calcium/blood ; Prognosis ; Biomarkers/blood ; Adult ; Follow-Up Studies ; Parathyroid Hormone/blood
مستخلص: Background: Patients with primary hyperparathyroidism (PHPT) are at risk for severe hypocalcemia (SH) following parathyroidectomy (PTX), but limited data exist on the predictors of SH. We aimed to identify risk factors for early postoperative SH after PTX in patients with PHPT and to evaluate the predictive value of clinical parameters.
Methods: A retrospective review of patients with PHPT who underwent PTX between January 2010 and December 2022 was performed. A total of 46 patients were included in the study, with 15 (32.6%) experiencing postoperative SH, 19 (41.3%) having calculi in the ureter or kidney, and 37 (80.4%) having osteoporosis. Patients were divided into SH and non-SH groups based on postoperative serum calcium levels. Preoperative biochemical indicators, bone turnover markers, and renal function parameters were analyzed and correlated with postoperative SH.
Results: Statistically significant (P < 0.05) differences were found in preoperative serum calcium (serum Ca), intact parathyroid hormone, serum phosphorus (serum P), serum Ca/P, percentage decrease of serum Ca, total procollagen type 1 intact N-terminal propeptide, osteocalcin (OC), and alkaline phosphatase levels between the two groups. Multivariate analysis showed that serum P (odds ratio [OR] = 0.989; 95% confidence interval [95% CI] = 0.981-0.996; P = 0.003), serum Ca (OR = 0.007; 95% CI = 0.001-0.415; P = 0.017), serum Ca/P (OR = 0.135; 95% CI = 0.019-0.947; P = 0.044) and OC levels (OR = 1.012; 95% CI = 1.001-1.024; P = 0.036) were predictors of early postoperative SH. The receiver operating characteristic curve analysis revealed that serum P (area under the curve [AUC] = 0.859, P < 0.001), serum Ca/P (AUC = 0.735, P = 0.010) and OC (AUC = 0.729, P = 0.013) had high sensitivity and specificity.
Conclusion: Preoperative serum P, serum Ca/P and osteocalcin levels may identify patients with PHPT at risk for early postoperative SH after PTX.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Calcium supplementation; Hungry bone syndrome; Osteocalcin; Parathyroidectomy; Postoperative severe hypocalcemia; Primary hyperparathyroidism; Serum phosphorus
المشرفين على المادة: SY7Q814VUP (Calcium)
0 (Biomarkers)
0 (Parathyroid Hormone)
تواريخ الأحداث: Date Created: 20240612 Date Completed: 20240613 Latest Revision: 20240615
رمز التحديث: 20240615
مُعرف محوري في PubMed: PMC11167831
DOI: 10.1186/s12902-024-01620-6
PMID: 38867205
قاعدة البيانات: MEDLINE
الوصف
تدمد:1472-6823
DOI:10.1186/s12902-024-01620-6