دورية أكاديمية
Adrenal gland macrophages regulate glucocorticoid production through Trem2 and TGF-β.
| العنوان: | Adrenal gland macrophages regulate glucocorticoid production through Trem2 and TGF-β. |
|---|---|
| المؤلفون: | Xu Y; Center for Immunology and.; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota, USA., Patterson MT; Center for Immunology and.; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota, USA., Dolfi B; Université Côte d'Azur, CNRS, LP2M, Nice, France., Zhu A; Center for Immunology and.; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota, USA., Bertola A; Université Côte d'Azur, CNRS, LP2M, Nice, France., Schrank PR; Center for Immunology and.; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota, USA., Gallerand A; Université Côte d'Azur, CNRS, LP2M, Nice, France., Kennedy AE; Center for Immunology and.; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota, USA., Hillman H; Center for Immunology and.; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota, USA., Dinh L; Center for Immunology and.; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota, USA., Shekhar S; Center for Immunology and.; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota, USA., Tollison S; Center for Immunology and.; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota, USA., Bold TD; Center for Immunology and.; Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Ivanov S; Université Côte d'Azur, CNRS, LP2M, Nice, France., Williams JW; Center for Immunology and.; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota, USA. |
| المصدر: | JCI insight [JCI Insight] 2024 Jun 13; Vol. 9 (14). Date of Electronic Publication: 2024 Jun 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Ann Arbor, Michigan : American Society for Clinical Investigation, [2016]- |
| مستخلص: | Glucocorticoid synthesis by adrenal glands (AGs) is regulated by the hypothalamic-pituitary-adrenal axis to facilitate stress responses when the host is exposed to stimuli. Recent studies implicate macrophages as potential steroidogenic regulators, but the molecular mechanisms by which AG macrophages exert such influence remain unclear. In this study, we investigated the role of AG macrophages in response to cold challenge or atherosclerotic inflammation as physiologic models of acute or chronic stress. Using single-cell RNA sequencing, we observed dynamic AG macrophage polarization toward classical activation and lipid-associated phenotypes following acute or chronic stimulation. Among transcriptional alterations induced in macrophages, triggering receptor expressed on myeloid cells 2 (Trem2) was highlighted because of its upregulation following stress. Conditional deletion of macrophage Trem2 revealed a protective role in stress responses. Mechanistically, Trem2 deletion led to increased AG macrophage death, abolished the TGF-β-producing capacity of AG macrophages, and resulted in enhanced glucocorticoid production. In addition, enhanced glucocorticoid production was replicated by blockade of TGF-β signaling. Together, these observations suggest that AG macrophages restrict steroidogenesis through Trem2 and TGF-β, which opens potential avenues for immunotherapeutic interventions to resolve stress-related disorders. |
| فهرسة مساهمة: | Keywords: Cytokines; Endocrinology; Immunology; Macrophages |
| تواريخ الأحداث: | Date Created: 20240613 Latest Revision: 20240812 |
| رمز التحديث: | 20240813 |
| DOI: | 10.1172/jci.insight.174746 |
| PMID: | 38869957 |
| قاعدة البيانات: | MEDLINE |
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