دورية أكاديمية
A Lung-Expressing mRNA Delivery Platform with Tunable Activity in Hypoxic Environments.
العنوان: | A Lung-Expressing mRNA Delivery Platform with Tunable Activity in Hypoxic Environments. |
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المؤلفون: | Tiwade PB; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Ma Y; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., VanKeulen-Miller R; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Fenton OS; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States. |
المصدر: | Journal of the American Chemical Society [J Am Chem Soc] 2024 Jun 26; Vol. 146 (25), pp. 17365-17376. Date of Electronic Publication: 2024 Jun 14. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Washington, DC : American Chemical Society Original Publication: Easton, Pa. [etc.] |
مواضيع طبية MeSH: | RNA, Messenger*/genetics , RNA, Messenger*/metabolism , RNA, Messenger*/administration & dosage , Lung*/metabolism, Humans ; Animals ; Mice ; Nanoparticles/chemistry ; Cell Hypoxia ; Hypoxia/metabolism |
مستخلص: | Messenger RNA (mRNA) delivery platforms often facilitate protein expression in the liver following intravenous injection and have been optimized for use in normally oxygenated cells (21% O |
المشرفين على المادة: | 0 (RNA, Messenger) |
تواريخ الأحداث: | Date Created: 20240614 Date Completed: 20240626 Latest Revision: 20240626 |
رمز التحديث: | 20240626 |
DOI: | 10.1021/jacs.4c04565 |
PMID: | 38874565 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1520-5126 |
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DOI: | 10.1021/jacs.4c04565 |