دورية أكاديمية
Hypertension Likely Drives Arteriolar Wall Thickening in Preclinical Diabetic Retinopathy While Diabetes Drives Wall Thickness in Clinical Retinopathy.
| العنوان: | Hypertension Likely Drives Arteriolar Wall Thickening in Preclinical Diabetic Retinopathy While Diabetes Drives Wall Thickness in Clinical Retinopathy. |
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| المؤلفون: | Huang BB; Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Fawzi AA; Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. |
| المصدر: | Translational vision science & technology [Transl Vis Sci Technol] 2024 Jun 03; Vol. 13 (6), pp. 8. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Association for Research in Vision and Ophthalmology Country of Publication: United States NLM ID: 101595919 Publication Model: Print Cited Medium: Internet ISSN: 2164-2591 (Electronic) Linking ISSN: 21642591 NLM ISO Abbreviation: Transl Vis Sci Technol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Rockville, Md. : Association for Research in Vision and Ophthalmology |
| مواضيع طبية MeSH: | Diabetic Retinopathy*/pathology , Hypertension*/complications , Hypertension*/pathology , Ophthalmoscopy*, Humans ; Cross-Sectional Studies ; Male ; Female ; Middle Aged ; Prospective Studies ; Arterioles/pathology ; Arterioles/diagnostic imaging ; Aged ; Adult ; Retinal Artery/pathology ; Retinal Artery/diagnostic imaging ; Macular Edema/pathology ; Macular Edema/diagnostic imaging ; Macular Edema/etiology |
| مستخلص: | Purpose: Both hypertension and diabetes are known to increase the wall-to-lumen ratio (WLR) of retinal arterioles, but the differential effects are unknown. Here, we study the timing and relative impact of hypertension versus diabetes on the WLR in diabetic retinopathy (DR) to address this unresolved question. Methods: This prospective cross-sectional study compared the retinal arteriolar WLR in 17 healthy eyes, 15 with diabetes but no apparent DR (DM no DR), and 8 with diabetic macular edema (DME) and either nonproliferative or proliferative DR. We imaged each arteriole using adaptive optics scanning laser ophthalmoscopy and measured the WLR using ImageJ. Multiple linear regression (MLR) was performed to estimate the effects of hypertension, diabetes, and age on the WLR. Results: Both subjects with DM no DR and subjects with DME had significantly higher WLR than healthy subjects (0.36 ± 0.08 and 0.42 ± 0.08 vs. 0.29 ± 0.07, 1-way ANOVA P = 0.0009). MLR in healthy subjects and subjects with DM no DR showed hypertension had the strongest effect (regression coefficient = 0.08, P = 0.009), whereas age and diabetes were not significantly correlated with WLR. MLR in all three groups together (healthy, DM no DR, and DME) showed diabetes had the strongest effect (regression coefficient = 0.05, P = 0.02), whereas age and hypertension were not significantly correlated with WLR. Conclusions: Hypertension may be an early driver of retinal arteriolar wall thickening in preclinical DR, independent of age or diabetes, whereas changes specific to DR may drive wall thickening in DME and later DR stages. Translational Relevance: We offer a framework for understanding the relative contributions of hypertension and diabetes on the vascular wall, and emphasize the importance of hypertension control early in diabetes even before DR onset. |
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| معلومات مُعتمدة: | R01 EY031815 United States EY NEI NIH HHS; T35 DK126628 United States DK NIDDK NIH HHS |
| تواريخ الأحداث: | Date Created: 20240614 Date Completed: 20240614 Latest Revision: 20240620 |
| رمز التحديث: | 20240620 |
| مُعرف محوري في PubMed: | PMC11182368 |
| DOI: | 10.1167/tvst.13.6.8 |
| PMID: | 38874974 |
| قاعدة البيانات: | MEDLINE |
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