دورية أكاديمية
In vitro antiproliferative effects of Vatairea macrocarpa (Benth.) Ducke lectin on human tumor cell lines and in vivo evaluation of its toxicity in Drosophila melanogaster.
| العنوان: | In vitro antiproliferative effects of Vatairea macrocarpa (Benth.) Ducke lectin on human tumor cell lines and in vivo evaluation of its toxicity in Drosophila melanogaster. |
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| المؤلفون: | Costa AR; Center for Agricultural Sciences and Biodiversity, Universidade Federal do Cariri, Crato, CE, Brazil., Santos AMO; Department of Genetics, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., Barreto FS; Department of Physiology and Pharmacology, Universidade Federal do Ceará, Fortaleza, CE, Brazil., Costa PMS; Department of Physiology and Pharmacology, Universidade Federal do Ceará, Fortaleza, CE, Brazil., Roma RR; Department of Biochemistry and Molecular Biology, Universidade Federal do Ceará, Fortaleza, CE, Brazil., Rocha BAM; Department of Biochemistry and Molecular Biology, Universidade Federal do Ceará, Fortaleza, CE, Brazil., Oliveira CVB; Department of Biological Sciences, Universidade Regional do Cariri, Crato, CE, Brazil., Duarte AE; Department of Biological Sciences, Universidade Regional do Cariri, Crato, CE, Brazil., Pessoa C; Department of Physiology and Pharmacology, Universidade Federal do Ceará, Fortaleza, CE, Brazil., Teixeira CS; Center for Agricultural Sciences and Biodiversity, Universidade Federal do Cariri, Crato, CE, Brazil. Electronic address: claudener@gmail.com. |
| المصدر: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2024 Aug; Vol. 190, pp. 114815. Date of Electronic Publication: 2024 Jun 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8207483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6351 (Electronic) Linking ISSN: 02786915 NLM ISO Abbreviation: Food Chem Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Exeter : Elsevier Science Ltd Original Publication: Oxford ; New York : Pergamon Press, c1982- |
| مواضيع طبية MeSH: | Drosophila melanogaster*/drug effects , Lectins*/pharmacology , Lectins*/toxicity, Animals ; Humans ; Cell Line, Tumor ; Cell Proliferation/drug effects ; HL-60 Cells ; Oxidative Stress/drug effects |
| مستخلص: | Tumor cells may develop alterations in glycosylation patterns during the initial phase of carcinogenesis. These alterations may be important therapeutic targets for lectins with antitumor action. This work aimed to evaluate the in vitro cytotoxicity of VML on tumor and non-tumor cells (concentration of 25 μg/mL and then microdiluted) and evaluate its in vivo toxicity at different concentrations (1.8, 3.5 and 7.0 μg/mL), using Drosophila melanogaster. Toxicity in D. melanogaster evaluated mortality rate, as well as oxidative stress markers (TBARS, iron levels, nitric oxide levels, protein and non-protein thiols). The cytotoxicity assay showed that VML had cytotoxic effect on leukemic lines HL-60 (IC Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cytotoxicity; HL-60; Leukemia; Oxidative stress |
| المشرفين على المادة: | 0 (Lectins) |
| تواريخ الأحداث: | Date Created: 20240614 Date Completed: 20240711 Latest Revision: 20240806 |
| رمز التحديث: | 20240807 |
| DOI: | 10.1016/j.fct.2024.114815 |
| PMID: | 38876381 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-6351 |
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| DOI: | 10.1016/j.fct.2024.114815 |