Editorial & Opinion
Individualising goal-directed haemodynamic therapy: future iterations will require novel trial designs.
| العنوان: | Individualising goal-directed haemodynamic therapy: future iterations will require novel trial designs. |
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| المؤلفون: | Edwards MR; Department of Anaesthesia, Southampton General Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Perioperative & Critical Care Research Group, NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust/University of Southampton, Southampton, UK. Electronic address: mark.edwards2@uhs.nhs.uk. |
| المصدر: | British journal of anaesthesia [Br J Anaesth] 2024 Aug; Vol. 133 (2), pp. 241-244. Date of Electronic Publication: 2024 Jun 13. |
| نوع المنشور: | Editorial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 0372541 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-6771 (Electronic) Linking ISSN: 00070912 NLM ISO Abbreviation: Br J Anaesth Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2018- : [London] : Elsevier Original Publication: London, Eng. [etc.] |
| مواضيع طبية MeSH: | Cardiac Output*/physiology , Hemodynamics*/physiology, Humans ; Algorithms ; Clinical Trials as Topic/methods ; Fluid Therapy/methods ; Goals ; Perioperative Care/methods ; Precision Medicine/methods ; Precision Medicine/trends ; Research Design |
| مستخلص: | Variants of perioperative cardiac output-guided haemodynamic therapy algorithms have been tested over the last few decades, without clear evidence of effectiveness. Newer approaches have focussed on individualisation of physiological targets and have been tested in early efficacy trials. Uncertainty about the benefits remains. Adoption of novel trial designs could overcome the limitations of smaller trials of this complex intervention and accelerate the exploration of future developments. (Copyright © 2024. Published by Elsevier Ltd.) |
| فهرسة مساهمة: | Keywords: arterial waveform analysis; cardiac output; fluid responsiveness; goal-directed haemodynamic therapy; perioperative outcomes; stroke volume |
| تواريخ الأحداث: | Date Created: 20240614 Date Completed: 20240714 Latest Revision: 20240716 |
| رمز التحديث: | 20240716 |
| DOI: | 10.1016/j.bja.2024.04.050 |
| PMID: | 38876923 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1471-6771 |
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| DOI: | 10.1016/j.bja.2024.04.050 |