دورية أكاديمية
أعرض في EDS

Network enrichment significance testing in brain-phenotype association studies.

التفاصيل البيبلوغرافية
العنوان: Network enrichment significance testing in brain-phenotype association studies.
المؤلفون: Weinstein SM; Department of Epidemiology and Biostatistics, Temple University College of Public Health, Philadelphia, Pennsylvania, USA., Vandekar SN; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Li B; Department of Computer and Information Sciences, Temple University College of Science and Technology, Philadelphia, Pennsylvania, USA., Alexander-Bloch AF; Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Department of Child and Adolescent Psychiatry and Behavioral Science, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Raznahan A; Section on Developmental Neurogenomics, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland, USA., Li M; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Gur RE; Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Gur RC; Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Roalf DR; Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Park MTM; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Integrated Program in Neuroscience, McGill University, QC, Canada., Chakravarty M; Department of Psychiatry, McGill University, QC, Canada.; Cerebral Imaging Centre, Douglas Research Centre, McGill University, QC, Canada., Baller EB; Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Linn KA; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Satterthwaite TD; Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Shinohara RT; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
المصدر: Human brain mapping [Hum Brain Mapp] 2024 Jun 01; Vol. 45 (8), pp. e26714.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 9419065 Publication Model: Print Cited Medium: Internet ISSN: 1097-0193 (Electronic) Linking ISSN: 10659471 NLM ISO Abbreviation: Hum Brain Mapp Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Wiley
Original Publication: New York : Wiley-Liss, c1993-
مواضيع طبية MeSH: Phenotype* , Brain*/diagnostic imaging , Brain*/physiology, Humans ; Magnetic Resonance Imaging/methods ; Nerve Net/diagnostic imaging ; Nerve Net/physiology ; Cohort Studies ; Female ; Male
مستخلص: Functional networks often guide our interpretation of spatial maps of brain-phenotype associations. However, methods for assessing enrichment of associations within networks of interest have varied in terms of both scientific rigor and underlying assumptions. While some approaches have relied on subjective interpretations, others have made unrealistic assumptions about spatial properties of imaging data, leading to inflated false positive rates. We seek to address this gap in existing methodology by borrowing insight from a method widely used in genetics research for testing enrichment of associations between a set of genes and a phenotype of interest. We propose network enrichment significance testing (NEST), a flexible framework for testing the specificity of brain-phenotype associations to functional networks or other sub-regions of the brain. We apply NEST to study enrichment of associations with structural and functional brain imaging data from a large-scale neurodevelopmental cohort study.
(© 2024 The Author(s). Human Brain Mapping published by Wiley Periodicals LLC.)
التعليقات: Update of: bioRxiv. 2023 Nov 13:2023.11.10.566593. doi: 10.1101/2023.11.10.566593. (PMID: 38014137)
References: Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):. (PMID: 33811142)
Commun Biol. 2020 May 22;3(1):261. (PMID: 32444827)
Neuroimage. 2021 Aug 1;236:118052. (PMID: 33857618)
Cell Rep. 2022 Mar 29;38(13):110576. (PMID: 35354053)
Neuron. 2021 Sep 15;109(18):2820-2846. (PMID: 34270921)
J Neurosci. 2013 Oct 9;33(41):16249-61. (PMID: 24107956)
Brain. 2020 Dec 5;143(11):3294-3307. (PMID: 33278823)
Nat Methods. 2022 Nov;19(11):1472-1479. (PMID: 36203018)
Cereb Cortex. 2016 Jan;26(1):288-303. (PMID: 25316338)
Hum Brain Mapp. 2021 Nov;42(16):5175-5187. (PMID: 34519385)
Hum Brain Mapp. 2022 Oct 15;43(15):4650-4663. (PMID: 35730989)
Am J Med Genet B Neuropsychiatr Genet. 2015 Oct;168(7):517-27. (PMID: 26059482)
Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21219-21227. (PMID: 31570622)
Front Genet. 2020 Jun 30;11:654. (PMID: 32695141)
Cereb Cortex. 2018 Jan 1;28(1):281-294. (PMID: 29088339)
Neuroimage. 2014 Feb 1;86:544-53. (PMID: 23921101)
J Neurosci. 2015 Jan 14;35(2):599-609. (PMID: 25589754)
Stat Appl Genet Mol Biol. 2010;9:Article39. (PMID: 21044043)
Neuroimage. 2014 May 15;92:381-97. (PMID: 24530839)
Neuroimage. 2018 Sep;178:540-551. (PMID: 29860082)
J Psychiatry Neurosci. 2018 May;43(3):201-212. (PMID: 29688876)
Neuroimage. 2020 Oct 15;220:117038. (PMID: 32585343)
BMC Bioinformatics. 2017 Mar 4;18(1):151. (PMID: 28259142)
Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):771-778. (PMID: 31874926)
Cereb Cortex. 2018 Sep 1;28(9):3095-3114. (PMID: 28981612)
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50. (PMID: 16199517)
Neuroimage. 2022 Apr 1;249:118908. (PMID: 35032660)
Neuroimage. 2022 Dec 1;264:119721. (PMID: 36341953)
Nat Neurosci. 2023 Sep;26(9):1613-1629. (PMID: 37580620)
Neuroimage. 2016 Jan 1;124(Pt B):1115-1119. (PMID: 25840117)
Neuroimage. 2022 Jul 15;255:119192. (PMID: 35398279)
Nat Rev Neurosci. 2022 Aug;23(8):493-504. (PMID: 35641793)
Trends Cogn Sci. 2023 Feb;27(2):160-174. (PMID: 36437189)
Front Neurosci. 2018 May 31;12:354. (PMID: 29904338)
J Neurophysiol. 2011 Sep;106(3):1125-65. (PMID: 21653723)
Neuroimage. 2012 Aug 15;62(2):774-81. (PMID: 22248573)
معلومات مُعتمدة: R37 MH125829 United States MH NIMH NIH HHS; K23MH113118 United States MH NIMH NIH HHS; R01 MH120482 United States MH NIMH NIH HHS; R01MH112847 United States MH NIMH NIH HHS; R01MH113550 United States MH NIMH NIH HHS; R01NS112274 United States NS NINDS NIH HHS; R01 MH113550 United States MH NIMH NIH HHS; R01EB022573 United States EB NIBIB NIH HHS; R01MH119219 United States MH NIMH NIH HHS; R01MH123563 United States MH NIMH NIH HHS; ZIA MH002949 United States ImNIH Intramural NIH HHS; Brain and Behavior Research Foundation; 1ZIAMH002949 United States MH NIMH NIH HHS; R01MH132934 United States MH NIMH NIH HHS; R01 MH112847 United States MH NIMH NIH HHS; R01 EB022573 United States EB NIBIB NIH HHS; R01 NS112274 United States NS NINDS NIH HHS; R01 MH123550 United States MH NIMH NIH HHS; R01 MH123563 United States MH NIMH NIH HHS; R01MH120482 United States MH NIMH NIH HHS; R01 MH132934 United States MH NIMH NIH HHS; R37MH125829 United States MH NIMH NIH HHS; R01MH123550 United States MH NIMH NIH HHS; R01 MH119219 United States MH NIMH NIH HHS
فهرسة مساهمة: Keywords: brain networks; brain‐phenotype associations; enrichment; hypothesis testing
تواريخ الأحداث: Date Created: 20240615 Date Completed: 20240615 Latest Revision: 20240624
رمز التحديث: 20240624
مُعرف محوري في PubMed: PMC11179683
DOI: 10.1002/hbm.26714
PMID: 38878300
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-0193
DOI:10.1002/hbm.26714