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Islet-Resident Memory T Cells Orchestrate the Immunopathogenesis of Type 1 Diabetes through the FABP4-CXCL10 Axis.

التفاصيل البيبلوغرافية
العنوان: Islet-Resident Memory T Cells Orchestrate the Immunopathogenesis of Type 1 Diabetes through the FABP4-CXCL10 Axis.
المؤلفون: Wu X; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, 999077, P. R. China.; Department of Pharmacology & Pharmacy, The University of Hong Kong, Hong Kong, 999077, P. R. China., Cheong LY; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, 999077, P. R. China.; Department of Medicine, The University of Hong Kong, Hong Kong, 999077, P. R. China., Yuan L; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, 999077, P. R. China.; Department of Pharmacology & Pharmacy, The University of Hong Kong, Hong Kong, 999077, P. R. China., Jin L; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, 999077, P. R. China.; Department of Medicine, The University of Hong Kong, Hong Kong, 999077, P. R. China., Zhang Z; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, 999077, P. R. China.; Department of Pharmacology & Pharmacy, The University of Hong Kong, Hong Kong, 999077, P. R. China., Xiao Y; Second Xiangya Hospital, Key Laboratory of Diabetes Immunology, National Clinical Research Center for Metabolic Diseases, Central South University, Changsha, Hunan, 410083, P. R. China., Zhou Z; Second Xiangya Hospital, Key Laboratory of Diabetes Immunology, National Clinical Research Center for Metabolic Diseases, Central South University, Changsha, Hunan, 410083, P. R. China., Xu A; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, 999077, P. R. China.; Department of Pharmacology & Pharmacy, The University of Hong Kong, Hong Kong, 999077, P. R. China.; Department of Medicine, The University of Hong Kong, Hong Kong, 999077, P. R. China., Hoo RL; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, 999077, P. R. China.; Department of Pharmacology & Pharmacy, The University of Hong Kong, Hong Kong, 999077, P. R. China., Shu L; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, 999077, P. R. China.; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Department of Hematological Oncology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, P. R. China.
المصدر: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Aug; Vol. 11 (30), pp. e2308461. Date of Electronic Publication: 2024 Jun 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim : WILEY-VCH, [2014]-
مواضيع طبية MeSH: Diabetes Mellitus, Type 1*/immunology , Diabetes Mellitus, Type 1*/genetics , Fatty Acid-Binding Proteins*/genetics , Fatty Acid-Binding Proteins*/metabolism , Fatty Acid-Binding Proteins*/immunology , Mice, Inbred NOD* , Chemokine CXCL10*/genetics , Chemokine CXCL10*/metabolism , Chemokine CXCL10*/immunology , Islets of Langerhans*/immunology , Islets of Langerhans*/metabolism, Animals ; Mice ; Memory T Cells/immunology ; Memory T Cells/metabolism ; Disease Models, Animal ; Humans
مستخلص: Type 1 diabetes (T1D) is a chronic disease characterized by self-destruction of insulin-producing pancreatic β cells by cytotoxic T cell activity. However, the pathogenic mechanism of T cell infiltration remains obscure. Recently, tissue-resident memory T (T RM ) cells have been shown to contribute to cytotoxic T cell recruitment. T RM cells are found present in human pancreas and are suggested to modulate immune homeostasis. Here, the role of T RM cells in the development of T1D is investigated. The presence of T RM cells in pancreatic islets is observed in non-obese diabetic (NOD) mice before T1D onset. Mechanistically, elevated fatty acid-binding protein 4 (FABP4) potentiates the survival and alarming function of T RM cells by promoting fatty acid utilization and C-X-C motif chemokine 10 (CXCL10) secretion, respectively. In NOD mice, genetic deletion of FABP4 or depletion of T RM cells using CD69 neutralizing antibodies resulted in a similar reduction of pancreatic cytotoxic T cell recruitment, a delay in diabetic incidence, and a suppression of CXCL10 production. Thus, targeting FABP4 may represent a promising therapeutic strategy for T1D.
(© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.)
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معلومات مُعتمدة: 06172596 Health Medical Research Fund; 2022A1515010290 Guangdong Basic and Applied Basic Research Foundation; PT19200101 Sun Yat-sen University Hundred Talents Program; AoE/M-707/18 Hong Kong Research Grants Council/Area of Excellence; 2022YFA0806102 National Key R&D Program of China; SGDX20210823103537031 Shenzhen-Hong Kong-Macau Science and Technology Program; 82070860 National Natural Science Foundation of China (NSFC) grants; 82161138026 National Natural Science Foundation of China (NSFC) grants
فهرسة مساهمة: Keywords: CXCL10; CXCR3; FABP4; Type 1 diabetes; tissue‐resident memory T cells
المشرفين على المادة: 0 (Fatty Acid-Binding Proteins)
0 (Chemokine CXCL10)
0 (Fabp4 protein, mouse)
0 (Cxcl10 protein, mouse)
تواريخ الأحداث: Date Created: 20240617 Date Completed: 20240813 Latest Revision: 20240815
رمز التحديث: 20240815
مُعرف محوري في PubMed: PMC11321687
DOI: 10.1002/advs.202308461
PMID: 38884133
قاعدة البيانات: MEDLINE
الوصف
تدمد:2198-3844
DOI:10.1002/advs.202308461