دورية أكاديمية
A Prebiotic Pathway to Nicotinamide Adenine Dinucleotide.
| العنوان: | A Prebiotic Pathway to Nicotinamide Adenine Dinucleotide. |
|---|---|
| المؤلفون: | Bechtel M; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany., Kurrle NJ; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany., Trapp O; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany.; Max-Planck-Institute for Astronomy, Königstuhl 17, 69117, Heidelberg, Germany. |
| المصدر: | Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Aug 27; Vol. 30 (48), pp. e202402055. Date of Electronic Publication: 2024 Jul 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9513783 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3765 (Electronic) Linking ISSN: 09476539 NLM ISO Abbreviation: Chemistry Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Weinheim, Germany : Wiley-VCH |
| مواضيع طبية MeSH: | NAD*/chemistry , NAD*/metabolism, Ammonia/chemistry ; Niacinamide/chemistry ; Niacinamide/analogs & derivatives ; Phosphorylation ; Prebiotics ; Adenosine Monophosphate/chemistry ; Catalysis ; Acetaldehyde/chemistry ; Oxidation-Reduction ; Water/chemistry ; Pyridinium Compounds/chemistry ; Flavin-Adenine Dinucleotide/chemistry ; Flavin-Adenine Dinucleotide/metabolism |
| مستخلص: | Enzymes play a fundamental role in cellular metabolism. A wide range of enzymes require the presence of complementary coenzymes and cofactors to function properly. While coenzymes are believed to have been part of the last universal ancestor (LUCA) or have been present even earlier, the syntheses of crucial coenzymes like the redox-active coenzymes flavin adenine dinucleotide (FAD) or nicotinamide adenine dinucleotide (NAD + ) remain challenging. Here, we present a pathway to NAD + under prebiotic conditions starting with ammonia, cyanoacetaldehyde, prop-2-ynal and sugar-forming precursors, yielding in situ the nicotinamide riboside. Regioselective phosphorylation and water stable light activated adenosine monophosphate derivatives allow for topographically and irradiation-controlled formation of NAD + . Our findings indicate that NAD + , a coenzyme vital to life, can be formed non-enzymatically from simple organic feedstock molecules via photocatalytic activation under prebiotically plausible early Earth conditions in a continuous process under aqueous conditions. (© 2024 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.) |
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| معلومات مُعتمدة: | Molecular Life Volkswagen Foundation; 364653263 Deutsche Forschungsgemeinschaft; 390783311 Deutsche Forschungsgemeinschaft |
| فهرسة مساهمة: | Keywords: Coenzyme; Nucleotide; Phosphorylation; Prebiotic chemistry; Ribose |
| المشرفين على المادة: | 0U46U6E8UK (NAD) 7664-41-7 (Ammonia) 25X51I8RD4 (Niacinamide) 0 (Prebiotics) 0I8H2M0L7N (nicotinamide-beta-riboside) 415SHH325A (Adenosine Monophosphate) GO1N1ZPR3B (Acetaldehyde) 059QF0KO0R (Water) 0 (Pyridinium Compounds) 146-14-5 (Flavin-Adenine Dinucleotide) |
| تواريخ الأحداث: | Date Created: 20240617 Date Completed: 20240828 Latest Revision: 20240828 |
| رمز التحديث: | 20240828 |
| DOI: | 10.1002/chem.202402055 |
| PMID: | 38884181 |
| قاعدة البيانات: | MEDLINE |
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