دورية أكاديمية
Proofreading mechanisms of the innate immune receptor RIG-I: distinguishing self and viral RNA.
| العنوان: | Proofreading mechanisms of the innate immune receptor RIG-I: distinguishing self and viral RNA. |
|---|---|
| المؤلفون: | Solotchi M; Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, U.S.A.; Graduate School of Biomedical Sciences, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, U.S.A., Patel SS; Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, U.S.A. |
| المصدر: | Biochemical Society transactions [Biochem Soc Trans] 2024 Jun 26; Vol. 52 (3), pp. 1131-1148. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Portland Press On The Behalf Of The Biochemical Society Country of Publication: England NLM ID: 7506897 Publication Model: Print Cited Medium: Internet ISSN: 1470-8752 (Electronic) Linking ISSN: 03005127 NLM ISO Abbreviation: Biochem Soc Trans Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Portland Press On The Behalf Of The Biochemical Society |
| مواضيع طبية MeSH: | RNA, Viral*/metabolism , DEAD Box Protein 58*/metabolism , Immunity, Innate* , Receptors, Immunologic*/metabolism, Humans ; Animals ; RNA, Double-Stranded/metabolism ; Interferon-Induced Helicase, IFIH1/metabolism ; DEAD-box RNA Helicases/metabolism ; RNA Helicases/metabolism |
| مستخلص: | The RIG-I-like receptors (RLRs), comprising retinoic acid-inducible gene I (RIG-I), melanoma differentiation-associated gene 5 (MDA5), and laboratory of genetics and physiology 2 (LGP2), are pattern recognition receptors belonging to the DExD/H-box RNA helicase family of proteins. RLRs detect viral RNAs in the cytoplasm and respond by initiating a robust antiviral response that up-regulates interferon and cytokine production. RIG-I and MDA5 complement each other by recognizing different RNA features, and LGP2 regulates their activation. RIG-I's multilayered RNA recognition and proofreading mechanisms ensure accurate viral RNA detection while averting harmful responses to host RNAs. RIG-I's C-terminal domain targets 5'-triphosphate double-stranded RNA (dsRNA) blunt ends, while an intrinsic gating mechanism prevents the helicase domains from non-specifically engaging with host RNAs. The ATPase and RNA translocation activity of RIG-I adds another layer of selectivity by minimizing the lifetime of RIG-I on non-specific RNAs, preventing off-target activation. The versatility of RIG-I's ATPase function also amplifies downstream signaling by enhancing the signaling domain (CARDs) exposure on 5'-triphosphate dsRNA and promoting oligomerization. In this review, we offer an in-depth understanding of the mechanisms RIG-I uses to facilitate viral RNA sensing and regulate downstream activation of the immune system. (© 2024 The Author(s).) |
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| فهرسة مساهمة: | Keywords: RIG-I like receptors; helicase; nucleic acid receptors |
| المشرفين على المادة: | 0 (RNA, Viral) EC 3.6.4.13 (DEAD Box Protein 58) 0 (Receptors, Immunologic) EC 3.6.1.- (RIGI protein, human) 0 (RNA, Double-Stranded) EC 3.6.4.13 (Interferon-Induced Helicase, IFIH1) EC 3.6.4.13 (DEAD-box RNA Helicases) EC 3.6.1.- (IFIH1 protein, human) EC 3.6.4.13 (RNA Helicases) |
| تواريخ الأحداث: | Date Created: 20240617 Date Completed: 20240626 Latest Revision: 20240828 |
| رمز التحديث: | 20240828 |
| مُعرف محوري في PubMed: | PMC11346460 |
| DOI: | 10.1042/BST20230724 |
| PMID: | 38884803 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1470-8752 |
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| DOI: | 10.1042/BST20230724 |