دورية أكاديمية
Individual HLAs affect survival after allogeneic stem cell transplantation in adult T-cell leukaemia/lymphoma.
| العنوان: | Individual HLAs affect survival after allogeneic stem cell transplantation in adult T-cell leukaemia/lymphoma. |
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| المؤلفون: | Morishima S; Division of Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan., Yoshimitsu M; Department of Hematology and Rheumatology, Kagoshima University Hospital, Kagoshima, Japan., Shindo T; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Utsunomiya A; Department of Hematology, Imamura General Hospital, Kagoshima, Japan., Ishida T; Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Ito A; Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan., Nakano N; Department of Hematology, Imamura General Hospital, Kagoshima, Japan., Kawakita T; Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan., Eto T; Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan., Suehiro Y; Department of Hematology and Cell Therapy, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan., Itonaga H; Transfusion and Cell Therapy Unit, Nagasaki University Hospital, Nagasaki, Japan., Mori Y; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan., Miyazaki Y; Department of Hematology, Oita Prefectural Hospital, Oita, Japan., Kanda J; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Uchida N; Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan., Sawayama Y; Department of Hematology, Sasebo City General Hospital, Sasebo, Japan., Tomori S; Division of Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan., Ichinohe T; Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan., Atsuta Y; Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan.; Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Nagakute, Japan., Fukuda T; Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan., Kato K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. |
| مؤلفون مشاركون: | ATL Working Group of the Japanese Society for Transplantation and Cellular Therapy |
| المصدر: | HLA [HLA] 2024 Jun; Vol. 103 (6), pp. e15555. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Blackwell Country of Publication: England NLM ID: 101675570 Publication Model: Print Cited Medium: Internet ISSN: 2059-2310 (Electronic) Linking ISSN: 20592302 NLM ISO Abbreviation: HLA Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Wiley Blackwell, [2016]- |
| مواضيع طبية MeSH: | Leukemia-Lymphoma, Adult T-Cell*/mortality , Leukemia-Lymphoma, Adult T-Cell*/therapy , Leukemia-Lymphoma, Adult T-Cell*/immunology , Hematopoietic Stem Cell Transplantation*/methods , Transplantation, Homologous* , HLA Antigens*/immunology , HLA Antigens*/genetics , Graft vs Host Disease*/mortality , Graft vs Host Disease*/immunology, Humans ; Male ; Female ; Middle Aged ; Adult ; Retrospective Studies ; Aged ; Alleles ; Histocompatibility Testing ; Young Adult ; Japan ; Registries |
| مستخلص: | Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is the only curative therapy for adult T-cell leukaemia/lymphoma (ATL). Specific HLAs are associated with outcomes of immunotherapy and allo-HSCT. We hypothesised that individual HLAs would affect the clinical outcomes of ATL patients after allo-HSCT. Using data from a Japanese registry, we retrospectively analysed 829 patients with ATL who received transplants from HLA-identical sibling donors or HLA-A, -B, -C or -DRB1 allele-matched unrelated donors between 1996 and 2015. We evaluated the overall mortality risk of HLA-A, -B and -DR antigens with frequencies exceeding 3%. Outcomes were compared between transplants with or without specific HLA antigens. Of the 25 HLAs, two candidates were identified but showed no statistically significant differences by multiple comparison. HLA-B62 was associated with a lower risk of mortality (hazard ratio [HR], 0.68; 95% confidence interval [CI]: 0.51-0.90; p = 0.008), whereas HLA-B60 was associated with a higher risk of mortality (HR, 1.64; 95% CI: 1.19-2.27; p = 0.003). In addition, HLA-B62 was associated with a lower risk of transplant-related mortality (TRM) (HR, 0.52; 95% CI: 0.32-0.85, p = 0.009), whereas HLA-B60 was associated with a higher risk of grades III-IV acute graft-versus-host disease (HR, 2.63; 95% CI: 1.62-4.27; p < 0.001). Neither HLA influenced relapse. The higher risk of acute GVHD in HLA-B60-positive patients and the lower risk of TRM in HLA-B62-positive patients were consistent with previously obtained results from patients with other haematological malignancies. Consideration of HLA in ATL patients may help to predict risk and outcomes after allo-HSCT. (© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) |
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| معلومات مُعتمدة: | 20K08737 JSPS KAKENHI; 23K07863 JSPS KAKENHI |
| فهرسة مساهمة: | Keywords: HLA; adult T‐cell leukaemia/lymphoma; allogeneic stem cell transplantation; transplant outcomes |
| المشرفين على المادة: | 0 (HLA Antigens) |
| تواريخ الأحداث: | Date Created: 20240618 Date Completed: 20240618 Latest Revision: 20240618 |
| رمز التحديث: | 20240619 |
| DOI: | 10.1111/tan.15555 |
| PMID: | 38887872 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2059-2310 |
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| DOI: | 10.1111/tan.15555 |