دورية أكاديمية
Optical coherence tomography angiography in patients with bipolar disorder and major depressive disorder.
| العنوان: | Optical coherence tomography angiography in patients with bipolar disorder and major depressive disorder. |
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| المؤلفون: | Zinchuk M; Moscow Research and Clinical Center for Neuropsychiatry, Moscow Healthcare Department, Moscow, Russian Federation. Electronic address: mzinchuk@mail.ru., Popova S; Moscow Research and Clinical Center for Neuropsychiatry, Moscow Healthcare Department, Moscow, Russian Federation., Guekht A; Moscow Research and Clinical Center for Neuropsychiatry, Moscow Healthcare Department, Moscow, Russian Federation; Pirogov Russian National Research Medical University, Moscow, Russian Federation., Shpak A; Moscow Research and Clinical Center for Neuropsychiatry, Moscow Healthcare Department, Moscow, Russian Federation; S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation. |
| المصدر: | Journal of affective disorders [J Affect Disord] 2024 Sep 15; Vol. 361, pp. 409-414. Date of Electronic Publication: 2024 Jun 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Depressive Disorder, Major*/diagnostic imaging , Tomography, Optical Coherence* , Bipolar Disorder*/diagnostic imaging , Bipolar Disorder*/physiopathology, Humans ; Female ; Male ; Adult ; Middle Aged ; Retinal Vessels/diagnostic imaging ; Retinal Vessels/pathology ; Fovea Centralis/diagnostic imaging ; Fovea Centralis/blood supply |
| مستخلص: | Background: Cerebral microvascular dysfunction is a promising area for research into the pathogenesis of major depressive disorder (MDD) and bipolar disorder (BD). Despite the scientific and clinical potential of studying microvascular dysfunction, progress in this area has long been hampered by the lack of methods to study microvessels intravitally. Aims: The aim of the present study was to search for potential optical coherence tomography (OCT) and OCT-angiography (OCTA) biomarkers of BD and MDD. Methods: One hundred and five consecutive patients with a current depressive episode were enrolled in the study (39 - BD and 66 - MDD). In addition, forty-one generally healthy subjects were enrolled as a control group. Only the right eye was examined in all subjects. Structural OCT and OCTA scans with signal strength ≥7 were included. Results: Structural OCT measurements showed no significant differences between the groups. OCTA measurements of foveal avascular zone (FAZ), area and skeleton density showed a decrease in the retinal capillary bed in BD patients, whereas OCTA values in MDD patients did not differ from the control group. Several significant differences were found between the BD and control groups. In the BD group, the FAZ of the deep capillary plexus was increased, reflecting a reduction in capillary perfusion in the central subfield of this plexus. Conclusions: OCTA measurements of FAZ, area and skeleton density showed a decrease in the retinal capillary bed in BD patients, whereas OCTA values in MDD patients did not differ from the control group. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could appear to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Bipolar disorder; Foveal avascular zone; Major depressive disorder; Optical coherence tomography; Optical coherence tomography angiography; Retina |
| تواريخ الأحداث: | Date Created: 20240618 Date Completed: 20240715 Latest Revision: 20240715 |
| رمز التحديث: | 20240716 |
| DOI: | 10.1016/j.jad.2024.06.039 |
| PMID: | 38889857 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1573-2517 |
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| DOI: | 10.1016/j.jad.2024.06.039 |