دورية أكاديمية
أعرض في EDS

Whey Protein Sodium-Caseinate as a Deliverable Vector for EGCG: In Vitro Optimization of Its Bioaccessibility, Bioavailability, and Bioactivity Mode of Actions.

التفاصيل البيبلوغرافية
العنوان: Whey Protein Sodium-Caseinate as a Deliverable Vector for EGCG: In Vitro Optimization of Its Bioaccessibility, Bioavailability, and Bioactivity Mode of Actions.
المؤلفون: Korin A; College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.; Food Science and Technology Department, Faculty of Agriculture, Al-Azhar University, Cairo 11651, Egypt., Gouda MM; College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.; College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China.; Department of Nutrition & Food Science, National Research Centre, Dokki, Giza 12622, Egypt., Youssef M; College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.; Food Science and Technology Department, Faculty of Agriculture, Al-Azhar University, Cairo 11651, Egypt., Elsharkawy E; Faculty of Science, Northern Border University, Arar 91431, Saudi Arabia., Albahi A; College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.; National Food Research Centre, Ministry of Agriculture and Natural Resources, Khartoum 113, Sudan., Zhan F; College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China., Sobhy R; Department of Biochemistry, Faculty of Agriculture, Benha University, Moshtohor 13736, Egypt., Li B; College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2024 May 31; Vol. 29 (11). Date of Electronic Publication: 2024 May 31.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Catechin*/analogs & derivatives , Catechin*/chemistry , Whey Proteins*/chemistry , Caseins*/chemistry , Biological Availability* , Emulsions*/chemistry, Humans ; Caco-2 Cells ; Molecular Docking Simulation ; Reactive Oxygen Species/metabolism ; Oxidative Stress/drug effects ; Drug Carriers/chemistry ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Antioxidants/pharmacokinetics ; Intestinal Absorption/drug effects
مستخلص: Epigallocatechin gallate (EGCG), the principal catechin in green tea, exhibits diverse therapeutic properties. However, its clinical efficacy is hindered by poor stability and low bioavailability. This study investigated solid particle-in-oil-in-water (S/O/W) emulsions stabilized by whey protein isolate (WPI) and sodium caseinate (NaCas) as carriers to enhance the bioavailability and intestinal absorption of EGCG. Molecular docking revealed binding interactions between EGCG and these macromolecules. The WPI- and NaCas-stabilized emulsions exhibited high encapsulation efficiencies (>80%) and significantly enhanced the bioaccessibility of EGCG by 64% compared to free EGCG after simulated gastrointestinal digestion. Notably, the NaCas emulsion facilitated higher intestinal permeability of EGCG across Caco-2 monolayers, attributed to the strong intermolecular interactions between caseins and EGCG. Furthermore, the emulsions protected Caco-2 cells against oxidative stress by suppressing intracellular reactive oxygen species generation. These findings demonstrate the potential of WPI- and NaCas-stabilized emulsions as effective delivery systems to improve the bioavailability, stability, and bioactivity of polyphenols like EGCG, enabling their applications in functional foods and nutraceuticals.
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معلومات مُعتمدة: 32202229 National Natural Science Foundation of China; NBU-FPEJ-2024-249-01 deanship of Scientific research, Northern border university
فهرسة مساهمة: Keywords: Caco-2 cell assay; anti-proliferative activity; bioaccessibility; epigallocatechin gallate; molecular docking; polyphenol
المشرفين على المادة: 8R1V1STN48 (Catechin)
BQM438CTEL (epigallocatechin gallate)
0 (Whey Proteins)
0 (Caseins)
0 (Emulsions)
0 (Reactive Oxygen Species)
0 (Drug Carriers)
0 (Antioxidants)
تواريخ الأحداث: Date Created: 20240619 Date Completed: 20240619 Latest Revision: 20240620
رمز التحديث: 20240620
مُعرف محوري في PubMed: PMC11174060
DOI: 10.3390/molecules29112588
PMID: 38893466
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules29112588