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Substance use and incidence of metabolic syndrome before midlife among military adults: the CHIEF cohort study.

التفاصيل البيبلوغرافية
العنوان: Substance use and incidence of metabolic syndrome before midlife among military adults: the CHIEF cohort study.
المؤلفون: Liu WN; Department of Medicine, Hualien Armed Forces General Hospital, Hualien City, Taiwan.; Department of Biomedical Sciences and Engineering, National Central University, Taoyuan, Taiwan.; Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Hsu YC; Department of Biomedical Sciences and Engineering, National Central University, Taoyuan, Taiwan., Lin YP; Department of Biomedical Sciences and Engineering, National Central University, Taoyuan, Taiwan.; Department of Stomatology of Periodontology, Mackay Memorial Hospital, Taipei, Taiwan., Tsai KZ; Department of Medicine, Hualien Armed Forces General Hospital, Hualien City, Taiwan.; Department of Stomatology of Periodontology, Mackay Memorial Hospital, Taipei, Taiwan.; Department of Dentistry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Chang YC; School of Nursing and Graduate, Institute of Nursing, China Medical University, Taichung, Taiwan.; Department of Nursing, China Medical University Hospital, Taichung, Taiwan., Liu PY; Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Lin GM; Department of Medicine, Hualien Armed Forces General Hospital, Hualien City, Taiwan.; Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
المصدر: Frontiers in public health [Front Public Health] 2024 Jun 04; Vol. 12, pp. 1406524. Date of Electronic Publication: 2024 Jun 04 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Editorial Office Country of Publication: Switzerland NLM ID: 101616579 Publication Model: eCollection Cited Medium: Internet ISSN: 2296-2565 (Electronic) Linking ISSN: 22962565 NLM ISO Abbreviation: Front Public Health Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Editorial Office
مواضيع طبية MeSH: Military Personnel*/statistics & numerical data , Metabolic Syndrome*/epidemiology, Humans ; Male ; Female ; Adult ; Taiwan/epidemiology ; Incidence ; Young Adult ; Adolescent ; Alcohol Drinking/epidemiology ; Alcohol Drinking/adverse effects ; Substance-Related Disorders/epidemiology ; Risk Factors ; Areca/adverse effects ; Cohort Studies
مستخلص: Backgrounds: Habitual substance use, i. e., alcohol, tobacco and betel nut, has been found with an increased risk of metabolic syndrome (MetS) in the general population, whereas the association remains unclear in physically fit military personnel. This study aimed to investigate the combination of these substances use and their associations with new-onset MetS in the military.
Methods: A total of 2,890 military men and women, aged 18-39 years, without MetS were obtained from the cardiorespiratory fitness and health in eastern armed forces study (CHIEF) in Taiwan and followed for incident MetS from baseline (2014) through the end of 2020. Incident MetS event was defined by the International Diabetes Federation guideline and confirmed in the annual health examinations. A self-report was used to assess the alcohol, tobacco and betel nut use status (active vs. former/never). Multivariable Cox regression model was performed to determine the association with adjustments for sex, age, body mass index and physical activity at baseline.
Results: At baseline, there were 279 active betel nut chewers (9.7%), 991 active smokers (34.3%) and 1,159 active alcohol consumers (40.1%). During a mean follow-up of 6.0 years, 673 incident MetS (23.3%) were observed. As compared to no substance users, only one substance, and two and three substances users had a greater risk of incident MetS [hazard ratios (HRs) and 95% confidence intervals: 1.27 (1.06-1.54), 1.38 (1.12-1.69) and 1.78 (1.37-2.32), respectively]. In subgroup analyses, the risk of incident MetS in two and three substances users was significantly greater in those free of baseline low high-density lipoprotein [HRs: 1.54 (1.21-1.95) and 2.57 (1.92-3.46), respectively], as compared to their counterparts (both p for interactions <0.05).
Conclusion: A dose-response association of more substances use for new-onset MetS was noted in military personnel. This finding suggests that the combined alcohol, tobacco and betel nut use may play a role in the development of MetS. Further study is required to establish causation and to investigate the potential benefits of substance use cessation in reducing the risk of MetS.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
(Copyright © 2024 Liu, Hsu, Lin, Tsai, Chang, Liu and Lin.)
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فهرسة مساهمة: Keywords: cohort study; metabolic syndrome; military personnel; physical activity; substance use
تواريخ الأحداث: Date Created: 20240619 Date Completed: 20240619 Latest Revision: 20240620
رمز التحديث: 20240620
مُعرف محوري في PubMed: PMC11184061
DOI: 10.3389/fpubh.2024.1406524
PMID: 38894993
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-2565
DOI:10.3389/fpubh.2024.1406524