دورية أكاديمية
أعرض في EDS

Preservation of fat mass at the expense of lean mass in children with end-stage chronic liver disease.

التفاصيل البيبلوغرافية
العنوان: Preservation of fat mass at the expense of lean mass in children with end-stage chronic liver disease.
المؤلفون: Jayaprakash K; Children's Liver Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Wells JCK; Childhood Nutrition Research Centre, University College London, London, UK., Rajwal S; Children's Liver Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Mushtaq T; Children's Endocrinology Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Kyrana E; Institute of Liver Studies, King's College London, London, UK.
المصدر: Pediatric transplantation [Pediatr Transplant] 2024 Aug; Vol. 28 (5), pp. e14767.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9802574 Publication Model: Print Cited Medium: Internet ISSN: 1399-3046 (Electronic) Linking ISSN: 13973142 NLM ISO Abbreviation: Pediatr Transplant Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Copenhagen ; Malden, MA : Munksgaard, c1997-
مواضيع طبية MeSH: Liver Transplantation* , End Stage Liver Disease*/surgery , End Stage Liver Disease*/complications , Sarcopenia*/etiology , Body Composition*, Humans ; Retrospective Studies ; Male ; Female ; Child ; Child, Preschool ; Adolescent ; Absorptiometry, Photon ; Adipose Tissue ; Infant
مستخلص: Background: Sarcopenia predicts morbidity and mortality in end-stage chronic liver disease (ESCLD). Here, we describe changes in body composition in children with ESCLD before and after liver transplantation (LT).
Methods: Retrospective analysis of whole body DXA scans performed before and after LT over 4 years. Appendicular and whole-body fat mass and lean mass were expressed as fat mass (FMI) and lean mass (LMI) index z-scores. Sarcopenia was defined as leg LMI z-score <-1.96.
Results: Eighty-three DXA scans of children before or after LT were studied. Sarcopenia had a positive correlation with weight (0.8, p < .01), height (0.48, p < .05), and BMI z-score (0.77, p < .01), as well as arm, trunk, and total mean mass indices. It correlated negatively with indices of hypersplenism: PLTs (-0.57, p < .01), Neu (-0.50, p < .05), WCC (-0.44, p < .05), and days to discharge (-0.46, p < .05). At baseline: 13/25 (52%) children were sarcopenic and stayed in the hospital after LT for longer. Eight were stunted with a higher WCC and Ne/Ly ratio. All had normal FM indices. One year after LT, 12/26 children remained sarcopenic. Seven were stunted. Two years after LT, 5/15 were sarcopenic, and 5 were stunted. Three years after LT, 1/10 was sarcopenic, and 2 were stunted. By 4 years after LT, 1/7 was sarcopenic, and the same one was stunted. FM indices remained normal.
Conclusions: Sarcopenic patients stayed longer in the hospital after LT. Lean mass indices were mostly within the normal range by 4 years after LT. 32% of children were stunted, and markers of inflammation were correlated with stunting. Fat mass was preserved at the cost of lean mass.
(© 2024 Wiley Periodicals LLC.)
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فهرسة مساهمة: Keywords: bone density; children; fat mass; liver disease; sarcopenia
تواريخ الأحداث: Date Created: 20240619 Date Completed: 20240619 Latest Revision: 20240619
رمز التحديث: 20240619
DOI: 10.1111/petr.14767
PMID: 38895795
قاعدة البيانات: MEDLINE
الوصف
تدمد:1399-3046
DOI:10.1111/petr.14767