دورية أكاديمية
Direct and acute effects of advanced glycation end products on proteostasis in isolated mouse skeletal muscle.
| العنوان: | Direct and acute effects of advanced glycation end products on proteostasis in isolated mouse skeletal muscle. |
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| المؤلفون: | Zhao H; Laboratory of Sports and Exercise Medicine, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan.; Laboratory of Molecular Exercise Adaptation Sciences, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan., Iyama R; Laboratory of Sports and Exercise Medicine, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan.; Laboratory of Molecular Exercise Adaptation Sciences, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan., Kurogi E; Laboratory of Sports and Exercise Medicine, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan., Hayashi T; Laboratory of Sports and Exercise Medicine, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan., Egawa T; Laboratory of Molecular Exercise Adaptation Sciences, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan. |
| المصدر: | Physiological reports [Physiol Rep] 2024 Jun; Vol. 12 (12), pp. e16121. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM ID: 101607800 Publication Model: Print Cited Medium: Internet ISSN: 2051-817X (Electronic) Linking ISSN: 2051817X NLM ISO Abbreviation: Physiol Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Malden MA] : published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society, 2013- |
| مواضيع طبية MeSH: | Muscle, Skeletal*/metabolism , Muscle, Skeletal*/drug effects , Glycation End Products, Advanced*/metabolism , Proteostasis* , Endoplasmic Reticulum Stress*/drug effects, Animals ; Mice ; Male ; Receptor for Advanced Glycation End Products/metabolism ; Receptor for Advanced Glycation End Products/genetics ; Signal Transduction ; Autophagy ; Mice, Inbred C57BL ; TOR Serine-Threonine Kinases/metabolism |
| مستخلص: | Advanced glycation end products (AGEs) have been implicated in several skeletal muscle dysfunctions. However, whether the adverse effects of AGEs on skeletal muscle are because of their direct action on the skeletal muscle tissue is unclear. Therefore, this study aimed to investigate the direct and acute effects of AGEs on skeletal muscle using an isolated mouse skeletal muscle to eliminate several confounders derived from other organs. The results showed that the incubation of isolated mouse skeletal muscle with AGEs (1 mg/mL) for 2-6 h suppressed protein synthesis and the mechanistic target of rapamycin signaling pathway. Furthermore, AGEs showed potential inhibitory effects on protein degradation pathways, including autophagy and the ubiquitin-proteasome system. Additionally, AGEs stimulated endoplasmic reticulum (ER) stress by modulating the activating transcription factor 6, PKR-like ER kinase, C/EBP homologous protein, and altered inflammatory cytokine expression. AGEs also stimulated receptor for AGEs (RAGE)-associated signaling molecules, including mitogen-activated protein kinases. These findings suggest that AGEs have direct and acute effect on skeletal muscle and disturb proteostasis by modulating intracellular pathways such as RAGE signaling, protein synthesis, proteolysis, ER stress, and inflammatory cytokines. (© 2024 The Author(s). Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.) |
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| معلومات مُعتمدة: | 18H03148 Japan Society for the Promotion of Science London (JSPS); 21H03319 Japan Society for the Promotion of Science London (JSPS); 22K18413 Japan Society for the Promotion of Science London (JSPS); 22K19750 Japan Society for the Promotion of Science London (JSPS); 23H03283 Japan Society for the Promotion of Science London (JSPS); Nakatomi Foundation; Research Institute for Production Development; Kyoto University Foundation (KUF); ISHIZUE 2023 of Kyoto University |
| فهرسة مساهمة: | Keywords: AGEs; ER stress; protein synthesis; skeletal muscle |
| المشرفين على المادة: | 0 (Glycation End Products, Advanced) 0 (Receptor for Advanced Glycation End Products) EC 2.7.11.1 (TOR Serine-Threonine Kinases) |
| تواريخ الأحداث: | Date Created: 20240619 Date Completed: 20240619 Latest Revision: 20240720 |
| رمز التحديث: | 20240721 |
| مُعرف محوري في PubMed: | PMC11186708 |
| DOI: | 10.14814/phy2.16121 |
| PMID: | 38898369 |
| قاعدة البيانات: | MEDLINE |
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