دورية أكاديمية
Preclinical and clinical evidence of the association of colibactin-producing Escherichia coli with anxiety and depression in colon cancer.
| العنوان: | Preclinical and clinical evidence of the association of colibactin-producing Escherichia coli with anxiety and depression in colon cancer. |
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| المؤلفون: | Rondepierre F; Service de Psychiatrie de l'Adulte A et Psychologie Médicale, CHU Clermont-Ferrand, Clermont-Ferrand 63000, France., Meynier M; M2iSH, UMR 1071, INSERM, University of Clermont Auvergne, INRAE USC 1382, Clermont-Ferrand 63001, France.; NeuroDol, UMR 1107, INSERM, University of Clermont Auvergne, Clermont-Ferrand 63001, France., Gagniere J; M2iSH, UMR 1071, INSERM, University of Clermont Auvergne, INRAE USC 1382, Clermont-Ferrand 63001, France.; Department of Digestive Surgery, CHU de Clermont-Ferrand, Clermont-Ferrand 63001, France., Deneuvy V; Service de Psychiatrie de l'Adulte A et Psychologie Médicale, CHU Clermont-Ferrand, Clermont-Ferrand 63000, France., Deneuvy A; Department of Digestive Surgery, CHU de Clermont-Ferrand, Clermont-Ferrand 63001, France., Roche G; M2iSH, UMR 1071, INSERM, University of Clermont Auvergne, INRAE USC 1382, Clermont-Ferrand 63001, France., Baudu E; M2iSH, UMR 1071, INSERM, University of Clermont Auvergne, INRAE USC 1382, Clermont-Ferrand 63001, France.; NeuroDol, UMR 1107, INSERM, University of Clermont Auvergne, Clermont-Ferrand 63001, France., Pereira B; Biostatistics Unit, Department of Clinical Research and Innovation, CHU Clermont-Ferrand, Clermont-Ferrand 63000, France., Bonnet R; M2iSH, UMR 1071, INSERM, University of Clermont Auvergne, INRAE USC 1382, Clermont-Ferrand 63001, France.; Department of Bacteriology, CHU de Clermont-Ferrand, Clermont-Ferrand 63001, France., Barnich N; M2iSH, UMR 1071, INSERM, University of Clermont Auvergne, INRAE USC 1382, Clermont-Ferrand 63001, France., Carvalho FA; NeuroDol, UMR 1107, INSERM, University of Clermont Auvergne, Clermont-Ferrand 63001, France., Pezet D; M2iSH, UMR 1071, INSERM, University of Clermont Auvergne, INRAE USC 1382, Clermont-Ferrand 63001, France.; Department of Digestive Surgery, CHU de Clermont-Ferrand, Clermont-Ferrand 63001, France., Bonnet M; M2iSH, UMR 1071, INSERM, University of Clermont Auvergne, INRAE USC 1382, Clermont-Ferrand 63001, France. mathilde.bonnet@uca.fr., Jalenques I; Service de Psychiatrie de l'Adulte A et Psychologie Médicale, CHU Clermont-Ferrand, Clermont-Ferrand 63000, France.; Université Clermont Auvergne, INP, CNRS, Clermont Auvergne Institut Pascal, Clermont-Ferrand 63000, France. |
| المصدر: | World journal of gastroenterology [World J Gastroenterol] 2024 Jun 07; Vol. 30 (21), pp. 2817-2826. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 100883448 Publication Model: Print Cited Medium: Internet ISSN: 2219-2840 (Electronic) Linking ISSN: 10079327 NLM ISO Abbreviation: World J Gastroenterol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group Original Publication: Beijing : WJG Press, c1998- |
| مواضيع طبية MeSH: | Mice, Inbred C57BL* , Polyketides*/metabolism , Depression*/psychology , Depression*/microbiology , Gastrointestinal Microbiome* , Anxiety*/psychology , Anxiety*/microbiology , Anxiety*/etiology , Escherichia coli Infections*/psychology , Escherichia coli Infections*/microbiology , Disease Models, Animal* , Peptides*/metabolism, Animals ; Humans ; Male ; Mice ; Female ; Aged ; Middle Aged ; Escherichia coli/isolation & purification ; Colonic Neoplasms/psychology ; Colonic Neoplasms/microbiology ; Prevalence ; Brain-Gut Axis |
| مستخلص: | Background: The association between the intestinal microbiota and psychiatric disorders is becoming increasingly apparent. The gut microbiota contributes to colorectal carcinogenesis (CRC), as demonstrated with colibactin-producing Escherichia coli (CoPEC). Aim: To evaluate the association between CoPEC prevalence and anxiety- and depressive-like behaviors with both preclinical and clinical approaches. Methods: Patients followed after a CRC surgery and for whom the prevalence of CoPEC has been investigated underwent a psychiatric interview. Results were compared according to the CoPEC colonization. In parallel C57BL6/J wild type mice and mice with a CRC susceptibility were chronically infected with a CoPEC strain. Their behavior was assessed using the Elevated Plus Maze test, the Forced Swimming Test and the Behavior recognition system PhenoTyper ® . Results: In a limited cohort, all patients with CoPEC colonization presented with psychiatric disorders several years before cancer diagnosis, whereas only one patient (17%) without CoPEC did. This result was confirmed in C57BL6/J wild-type mice and in a CRC susceptibility mouse model (adenomatous polyposis coli multiple intestinal neoplasia/+ ). Mice exhibited a significant increase in anxiety- and depressive-like behaviors after chronic infection with a CoPEC strain. Conclusion: This finding provides the first evidence that CoPEC infection can induce microbiota-gut-brain axis disturbances in addition to its procarcinogenic properties. Competing Interests: Conflict-of-interest statement: Pr. Bonnet has nothing to disclose. (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.) |
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| فهرسة مساهمة: | Keywords: Anxiety; Behavior; Colibactin; Colibactin-producing Escherichia coli; Colorectal cancer; Depression; Escherichia coli; Inflammation |
| المشرفين على المادة: | 0 (colibactin) 0 (Polyketides) 0 (Peptides) |
| تواريخ الأحداث: | Date Created: 20240620 Date Completed: 20240620 Latest Revision: 20240621 |
| رمز التحديث: | 20240621 |
| مُعرف محوري في PubMed: | PMC11185296 |
| DOI: | 10.3748/wjg.v30.i21.2817 |
| PMID: | 38899326 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2219-2840 |
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| DOI: | 10.3748/wjg.v30.i21.2817 |