دورية أكاديمية
أعرض في EDS

Comprehensive Immunohistochemical Analysis of Epithelial-Mesenchymal Transition Biomarkers in the Invasive Micropapillary Cancer of the Breast.

التفاصيل البيبلوغرافية
العنوان: Comprehensive Immunohistochemical Analysis of Epithelial-Mesenchymal Transition Biomarkers in the Invasive Micropapillary Cancer of the Breast.
المؤلفون: Oz O; Izmir Bozyaka Training and Research Hospital Department of Pathology University of Health Sciences, Izmir, Türkiye., Tasli FA; Izmir Bozyaka Training and Research Hospital Department of Pathology University of Health Sciences, Izmir, Türkiye., Yuzuguldu RI; Faculty of Medicine Training and Research Hospital Departments of Pathology Mugla Sıtkı Koçman University, Mugla, Türkiye., Zengel B; Izmir Bozyaka Training and Research Hospital Department of Pathology University of Health Sciences, Izmir, Türkiye., Cavdar DK; Izmir Bozyaka Training and Research Hospital Department of Pathology University of Health Sciences, Izmir, Türkiye., Durak MG; Medical Faculty Departments of Pathology Dokuz Eylul University, Izmir, Türkiye., Durusoy R; Department of Public Health Medical Faculty Ege University, Izmir, Türkiye.
المصدر: International journal of breast cancer [Int J Breast Cancer] 2024 Jun 11; Vol. 2024, pp. 2350073. Date of Electronic Publication: 2024 Jun 11 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: Egypt NLM ID: 101568103 Publication Model: eCollection Cited Medium: Print ISSN: 2090-3170 (Print) Linking ISSN: 20903189 NLM ISO Abbreviation: Int J Breast Cancer Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Cairo : Hindawi Pub. Corp.
مستخلص: Background : Invasive micropapillary carcinoma (IMPC) of the breast is commonly associated with a poor prognosis due to its high incidence of lymphovascular invasion and lymph node metastasis (LNM). Our study is aimed at investigating the prognostic significance of the expressions of E-cadherin (E-cad), N-cadherin (N-cad), CD44s, and β -catenin ( β -cat). In addition, it is aimed at deciphering the consistency of these markers between the IMPC, the invasive breast carcinoma, no-special type (IBC-NST), and LNM components in the same IMPC cases. Methods: Sixty-two IMPC cases with LNM from 1996 to 2018 were analyzed. Immunohistochemical staining was performed separately on the three regions for each patient. Statistical analyses included Kaplan-Meier, Cox regression, and McNemar's statistical tests. Results: Loss of CD44 expression in IMPC, IBC-NST, and LNM areas was associated with poor prognosis in overall survival (OS) ( p = 0.010, p < 0.0005, p = 0.025). Loss of CD44 expression in the IBC-NST, gain of N-cad expression in the IMPC, and loss of β -cat expression in the LNM areas were indicators of poor prognosis in disease-free survival (DFS) ( p = 0.005, p = 0.041, p = 0.009). Conclusion: Our evaluation of this rare subtype, focusing on the expression of key epithelial-mesenchymal transition (EMT) molecules, revealed that it shares characteristics with the IBC-NST component within mixed tumors. Notably, contrary to expectations, a reduction in CD44 expression was found to adversely affect both OS and DFS. By conducting staining procedures simultaneously across three regions within the same patient, a novel approach has provided valuable insights into the mechanisms of EMT.
Competing Interests: The authors declare no conflicts of interest.
(Copyright © 2024 Ozden Oz et al.)
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فهرسة مساهمة: Keywords: biomarker; epithelial–mesenchymal transition (EMT); metastasis; micropapillary breast carcinoma; prognosis
تواريخ الأحداث: Date Created: 20240621 Latest Revision: 20240622
رمز التحديث: 20240622
مُعرف محوري في PubMed: PMC11189676
DOI: 10.1155/2024/2350073
PMID: 38903413
قاعدة البيانات: MEDLINE
الوصف
تدمد:2090-3170
DOI:10.1155/2024/2350073