دورية أكاديمية
أعرض في EDS

Investigating the influence of molybdenum disulfide quantum dots coated with DSPE-PEG-TPP on molecular structures of liver lipids and proteins: An in vivo study.

التفاصيل البيبلوغرافية
العنوان: Investigating the influence of molybdenum disulfide quantum dots coated with DSPE-PEG-TPP on molecular structures of liver lipids and proteins: An in vivo study.
المؤلفون: Ageeli AA; Department of Physical Sciences, Chemistry Division, College of Science, Jazan University, Jazan 45142, Saudi Arabia., Osrah B; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Alosaimi AM; Department of Chemistry, College of Science, Taif University, Taif 21944, Saudi Arabia., Alwafi R; Department of Physics, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Alghamdi SA; Advanced Materials Research Laboratory, Department of Physics, Faculty of Science, University of Tabuk, Tabuk, 71491, Saudi Arabia., Saeed A; Department of Physics, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Department of Physics, Thamar University, Thamar 87246, Yemen. Electronic address: Abdusaeed@tu.edu.ye.
المصدر: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2024 Nov 05; Vol. 320, pp. 124675. Date of Electronic Publication: 2024 Jun 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 9602533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3557 (Electronic) Linking ISSN: 13861425 NLM ISO Abbreviation: Spectrochim Acta A Mol Biomol Spectrosc Subsets: MEDLINE
أسماء مطبوعة: Publication: : Amsterdam : Elsevier
Original Publication: [Kidlington, Oxford, U.K. ; Tarrytown, NY] : Pergamon, c1994-
مواضيع طبية MeSH: Quantum Dots*/chemistry , Molybdenum*/chemistry , Disulfides*/chemistry , Liver*/drug effects , Liver*/metabolism , Polyethylene Glycols*/chemistry , Phosphatidylethanolamines*/chemistry, Animals ; Mice ; Spectroscopy, Fourier Transform Infrared ; Lipids/chemistry ; Male ; Proteins/chemistry
مستخلص: Molybdenum disulfide (MoS 2 ) quantum dots (QDs) based therapeutic approaches hold great promise for biomedical applications, necessitating a thorough evaluation of their potential effects on biological systems. In this study, we systematically investigated the impact of MoS 2 QDs coated with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethyleneglycol)-2000](DPSE-PEG) linked with (3-carboxypropyl)triphenyl-phosphonium-bromide (TPP) on molecular structures of hepatic tissue lipids and proteins through a multifaceted analysis. The DSPE-PEG-TPP-MoS 2 QDs were prepared and administered to the mice daily for 7 weeks. Liver tissues were subjected to a comprehensive examination using various techniques, including Fourier-transform infrared (FTIR) spectroscopy, UV-vis spectroscopy, and liver function tests. FTIR revealed subtle changes in the lipid composition of liver tissues, indicating potential modifications in the cell membrane structure. Also, the (CH stretching and amides I and II regions) analysis unveiled tiny alterations in lipid chain length and fluidity without changes in the protein structures, suggesting a minor influence of DSPE-PEG-TPP-MoS 2 QDs on the liver's cellular membrane and no effect on the protein structures. Further scrutiny using UV-vis spectroscopy demonstrated that DSPE-PEG-TPP-MoS 2 QDs had no discernible impact on the absorbance intensities of aromatic amino acids and the Soret band. This observation implies that the treatment with SPE-PEG-TPP-MoS 2 QDs did not induce significant alterations in helical conformation or the microenvironment surrounding prosthetic groups in liver tissues. The liver function tests, including ALP, ALT, AST, and BIL levels, revealed no statistically significant changes in these key biomarkers despite minor fluctuations in their values, indicating a lack of significant liver dysfunction. This study provides a detailed understanding of the effects of DSPE-PEG-TPP-MoS 2 QDs on hepatic lipids and proteins, offering valuable insights into the biocompatibility and limited impact on the molecular and functional aspects of the liver tissue. These findings could be essential for the application of MoS 2 QDs-based therapies.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: FTIR; Lipids; Liver; MoS(2) QDs; Molecular structure; Proteins; UV–Vis spectroscopy
المشرفين على المادة: 81AH48963U (Molybdenum)
0 (Disulfides)
ZC8B4P503V (molybdenum disulfide)
3WJQ0SDW1A (Polyethylene Glycols)
0 (Phosphatidylethanolamines)
0 (Lipids)
0 (Proteins)
0 (polyethylene glycol-distearoylphosphatidylethanolamine)
تواريخ الأحداث: Date Created: 20240621 Date Completed: 20240706 Latest Revision: 20240706
رمز التحديث: 20240707
DOI: 10.1016/j.saa.2024.124675
PMID: 38906057
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-3557
DOI:10.1016/j.saa.2024.124675