دورية أكاديمية
Dissolving microarray patches loaded with a rotigotine nanosuspension: A potential alternative to Neupro® patch.
| العنوان: | Dissolving microarray patches loaded with a rotigotine nanosuspension: A potential alternative to Neupro® patch. |
|---|---|
| المؤلفون: | Li Y; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, United Kingdom., Wang J; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, United Kingdom., Vora LK; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, United Kingdom., Sabri AHB; Faculty of Science, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom., McGuckin MB; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, United Kingdom., Paredes AJ; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, United Kingdom., Donnelly RF; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, United Kingdom. Electronic address: r.donnelly@qub.ac.uk. |
| المصدر: | Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2024 Aug; Vol. 372, pp. 304-317. Date of Electronic Publication: 2024 Jun 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science Publishers, 1984- |
| مواضيع طبية MeSH: | Thiophenes*/administration & dosage , Thiophenes*/pharmacokinetics , Thiophenes*/chemistry , Transdermal Patch* , Tetrahydronaphthalenes*/administration & dosage , Tetrahydronaphthalenes*/pharmacokinetics , Tetrahydronaphthalenes*/chemistry , Dopamine Agonists*/administration & dosage , Dopamine Agonists*/pharmacokinetics , Dopamine Agonists*/chemistry , Skin Absorption* , Administration, Cutaneous* , Nanoparticles*/chemistry, Animals ; Swine ; Suspensions ; Skin/metabolism ; Drug Liberation ; Male ; Solubility ; Particle Size |
| مستخلص: | Parkinson's disease (PD), affecting about ten million people globally, presents a significant health challenge. Rotigotine (RTG), a dopamine agonist, is currently administered as a transdermal patch (Neupro®) for PD treatment, but the daily application can be burdensome and cause skin irritation. This study introduces a combinatorial approach of dissolving microarray patch (MAP) and nanosuspension (NS) for the transdermal delivery of RTG, offering an alternative to Neupro®. The RTG-NS was formulated using a miniaturized media milling method, resulting in a nano-formulation with a mean particle size of 274.09 ± 7.43 nm, a PDI of 0.17 ± 0.04 and a zeta potential of -15.24 ± 2.86 mV. The in vitro dissolution study revealed an enhanced dissolution rate of the RTG-NS in comparison to the coarse RTG powder, under sink condition. The RTG-NS MAPs, containing a drug layer and a 'drug-free' supporting baseplate, have a drug content of 3.06 ± 0.15 mg/0.5 cm 2 and demonstrated greater amount of drug delivered per unit area (∼0.52 mg/0.5 cm 2 ) than Neupro® (∼0.20 mg/1 cm 2 ) in an ex vivo Franz cell study using full-thickness neonatal porcine skin. The in vivo pharmacokinetic studies demonstrated that RTG-NS MAPs, though smaller (2 cm 2 for dissolving MAPs and 6 cm 2 for Neupro®), delivered drug levels comparable to Neupro®, indicating higher efficiency per unit area. This could potentially avoid unnecessarily high plasma levels after the next dose at 24 h, highlighting the benefits of dissolving MAPs over conventional transdermal patches in PD treatment. (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.) |
| التعليقات: | Erratum in: J Control Release. 2024 Aug 24:S0168-3659(24)00575-3. doi: 10.1016/j.jconrel.2024.08.028. (PMID: 39181828) |
| فهرسة مساهمة: | Keywords: Microarray patch; Nanosuspension; Neupro® patch; Parkinson's disease; Rotigotine; Transdermal drug delivery |
| المشرفين على المادة: | 87T4T8BO2E (rotigotine) 0 (Thiophenes) 0 (Tetrahydronaphthalenes) 0 (Dopamine Agonists) 0 (Suspensions) |
| تواريخ الأحداث: | Date Created: 20240621 Date Completed: 20240727 Latest Revision: 20240824 |
| رمز التحديث: | 20240826 |
| DOI: | 10.1016/j.jconrel.2024.06.039 |
| PMID: | 38906420 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-4995 |
|---|---|
| DOI: | 10.1016/j.jconrel.2024.06.039 |