دورية أكاديمية
أعرض في EDS

Intermittent fasting induced cerebral ischemic tolerance altered gut microbiome and increased levels of short-chain fatty acids to a beneficial phenotype.

التفاصيل البيبلوغرافية
العنوان: Intermittent fasting induced cerebral ischemic tolerance altered gut microbiome and increased levels of short-chain fatty acids to a beneficial phenotype.
المؤلفون: Chelluboina B; Department of Neurological Surgery, University of Wisconsin-Madison, Madison, WI, USA., Cho T; Department of Neurological Surgery, University of Wisconsin-Madison, Madison, WI, USA., Park JS; Department of Neurological Surgery, University of Wisconsin-Madison, Madison, WI, USA., Mehta SL; Department of Neurological Surgery, University of Wisconsin-Madison, Madison, WI, USA., Bathula S; Department of Neurological Surgery, University of Wisconsin-Madison, Madison, WI, USA., Jeong S; Department of Neurological Surgery, University of Wisconsin-Madison, Madison, WI, USA; Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI, USA., Vemuganti R; Department of Neurological Surgery, University of Wisconsin-Madison, Madison, WI, USA; Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI, USA; William S. Middleton Veterans Administration Hospital, Madison, WI, USA. Electronic address: vemuganti@neurosurgery.wisc.edu.
المصدر: Neurochemistry international [Neurochem Int] 2024 Sep; Vol. 178, pp. 105795. Date of Electronic Publication: 2024 Jun 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 8006959 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9754 (Electronic) Linking ISSN: 01970186 NLM ISO Abbreviation: Neurochem Int Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford [Elmsford, N. Y.] Pergamon Press.
مواضيع طبية MeSH: Fatty Acids, Volatile*/metabolism , Gastrointestinal Microbiome*/physiology , Infarction, Middle Cerebral Artery*/metabolism , Intermittent Fasting*/metabolism, Animals ; Female ; Male ; Mice ; Brain Ischemia/metabolism ; Brain Ischemia/microbiology ; Mice, Inbred C57BL ; Phenotype
مستخلص: Preconditioning-induced cerebral ischemic tolerance is known to be a beneficial adaptation to protect the brain in an unavoidable event of stroke. We currently demonstrate that a short bout (6 weeks) of intermittent fasting (IF; 15 h fast/day) induces similar ischemic tolerance to that of a longer bout (12 weeks) in adult C57BL/6 male mice subjected to transient middle cerebral artery occlusion (MCAO). In addition, the 6 weeks IF regimen induced ischemic tolerance irrespective of age (3 months or 24 months) and sex. Mice subjected to transient MCAO following IF showed improved motor function recovery (rotarod and beam walk tests) between days 1 and 14 of reperfusion and smaller infarcts (T2-MRI) on day 1 of reperfusion compared with age/sex matched ad libitum (AL) controls. Diet influences the gut microbiome composition and stroke is known to promote gut bacterial dysbiosis. We presently show that IF promotes a beneficial phenotype of gut microbiome following transient MCAO compared with AL cohort. Furthermore, post-stroke levels of short-chain fatty acids (SCFAs), which are known to be neuroprotective, are higher in the fecal samples of the IF cohort compared with the AL cohort. Thus, our studies indicate the efficacy of IF in protecting the brain after stroke, irrespective of age and sex, probably by altering gut microbiome and SCFA production.
Competing Interests: Declaration of competing interest The authors declare no conflicts.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
References: Front Immunol. 2023 Jan 30;14:1087815. (PMID: 36793730)
Cells. 2023 Mar 13;12(6):. (PMID: 36980225)
Trends Microbiol. 2023 Aug;31(8):832-844. (PMID: 37031065)
J Cereb Blood Flow Metab. 2022 Feb;42(2):253-263. (PMID: 34689646)
Nat Rev Neurosci. 2018 Feb;19(2):63-80. (PMID: 29321682)
CNS Neurosci Ther. 2016 May;22(5):342-50. (PMID: 27012165)
Microorganisms. 2022 Mar 31;10(4):. (PMID: 35456812)
Nutr Rev. 2023 Aug 10;81(9):1225-1233. (PMID: 37043764)
Biomed J. 2024 Feb;47(1):100677. (PMID: 37940045)
Stroke. 2020 Oct;51(10):3138-3141. (PMID: 32819195)
J Cereb Blood Flow Metab. 2006 Sep;26(9):1103-13. (PMID: 16437060)
CNS Neurosci Ther. 2023 Jun;29 Suppl 1:185-199. (PMID: 37309254)
Exp Transl Stroke Med. 2011 Sep 12;3:8. (PMID: 21910904)
Imeta. 2022 Oct 13;1(4):e58. (PMID: 38867908)
Sci Rep. 2024 Jan 17;14(1):1515. (PMID: 38233519)
Nucleic Acids Res. 2002 Jul 15;30(14):3059-66. (PMID: 12136088)
Rejuvenation Res. 2021 Jun;24(3):234-237. (PMID: 34039011)
J Neurosci. 2020 Jan 29;40(5):1162-1173. (PMID: 31889008)
Exp Neurol. 2014 Jul;257:114-9. (PMID: 24805069)
Int Microbiol. 2023 Jan;26(1):51-57. (PMID: 35953616)
Nutrients. 2021 Sep 10;13(9):. (PMID: 34579042)
Ann Gastroenterol. 2015 Apr-Jun;28(2):203-209. (PMID: 25830558)
Stroke. 2022 May;53(5):1788-1801. (PMID: 35135325)
Int J Mol Sci. 2019 Apr 18;20(8):. (PMID: 31003407)
J Neuroinflammation. 2021 Mar 12;18(1):70. (PMID: 33712031)
Exp Ther Med. 2016 Nov;12(5):3021-3028. (PMID: 27882110)
Adv Biol (Weinh). 2023 Aug;7(8):e2200337. (PMID: 36950759)
Womens Health (Lond). 2011 May;7(3):319-39. (PMID: 21612353)
Appl Environ Microbiol. 2017 Oct 17;83(21):. (PMID: 28842545)
Front Cell Infect Microbiol. 2019 Feb 04;9:4. (PMID: 30778376)
J Cereb Blood Flow Metab. 2014 May;34(5):897-905. (PMID: 24549184)
Nutrients. 2023 Apr 26;15(9):. (PMID: 37432222)
Stroke. 2011 Sep;42(9):2645-50. (PMID: 21852620)
Cond Med. 2020 Feb;3(1):9-17. (PMID: 34278242)
Nutrients. 2022 Jan 31;14(3):. (PMID: 35276989)
J Cereb Blood Flow Metab. 2017 Nov;37(11):3488-3517. (PMID: 28797196)
Neurobiol Dis. 2020 Feb;134:104621. (PMID: 31628992)
Ann Nutr Metab. 2021;77 Suppl 2:36-44. (PMID: 34107468)
Nat Aging. 2021 Jan;1(1):47-59. (PMID: 35310455)
BMC Vet Res. 2020 Jul 14;16(1):242. (PMID: 32660541)
J Cereb Blood Flow Metab. 2009 Mar;29(3):486-94. (PMID: 19002196)
Nat Commun. 2020 Feb 18;11(1):855. (PMID: 32071312)
J Cereb Blood Flow Metab. 2021 Dec;41(12):3200-3212. (PMID: 34427146)
PLoS One. 2010 Mar 10;5(3):e9490. (PMID: 20224823)
Ann Neurol. 2010 Jan;67(1):41-52. (PMID: 20186857)
PLoS One. 2020 Jul 13;15(7):e0235498. (PMID: 32658916)
Semin Immunopathol. 2023 May;45(3):295-313. (PMID: 36355204)
iScience. 2022 Oct 25;25(11):105437. (PMID: 36388972)
Hum Microb J. 2020 Mar;15:None. (PMID: 34435164)
Cell Metab. 2014 Dec 2;20(6):991-1005. (PMID: 25470547)
CNS Neurosci Ther. 2019 Dec;25(12):1308-1317. (PMID: 31747126)
NPJ Biofilms Microbiomes. 2023 Apr 7;9(1):19. (PMID: 37029135)
Transl Stroke Res. 2023 Dec 22;:. (PMID: 38129636)
معلومات مُعتمدة: R35 NS132184 United States NS NINDS NIH HHS; IK6 BX005690 United States BX BLRD VA; I01 BX006062 United States BX BLRD VA; R01 NS130763 United States NS NINDS NIH HHS; I01 BX005127 United States BX BLRD VA
فهرسة مساهمة: Keywords: Aging; Brain damage; Dietary regimen; Gut dysbiosis; Neuroprotection; Preconditioning
المشرفين على المادة: 0 (Fatty Acids, Volatile)
تواريخ الأحداث: Date Created: 20240622 Date Completed: 20240801 Latest Revision: 20240923
رمز التحديث: 20240923
مُعرف محوري في PubMed: PMC11296926
DOI: 10.1016/j.neuint.2024.105795
PMID: 38908519
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-9754
DOI:10.1016/j.neuint.2024.105795