دورية أكاديمية
Update on lacrimal apparatus dysfunction associated with differentiated thyroid cancer after I-131 therapy.
العنوان: | Update on lacrimal apparatus dysfunction associated with differentiated thyroid cancer after I-131 therapy. |
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المؤلفون: | Liang C; Department of Ophthalmology, The First Affiliated Hospital of Jinan University, 613 West Huangpu Ave, Guangzhou, 510632, China., Wu C; Department of Ophthalmology, The First Affiliated Hospital of Jinan University, 613 West Huangpu Ave, Guangzhou, 510632, China., Liu L; Department of Ophthalmology, The First Affiliated Hospital of Jinan University, 613 West Huangpu Ave, Guangzhou, 510632, China. liulianbb@163.com., Zhong J; Department of Ophthalmology, The Sixth Affiliated Hospital of Jinan University, No. 88, Changdong Road, Dongguan, 523573, China. zjx85221206@126.com. |
المصدر: | International ophthalmology [Int Ophthalmol] 2024 Jun 23; Vol. 44 (1), pp. 257. Date of Electronic Publication: 2024 Jun 23. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Kluwer Country of Publication: Netherlands NLM ID: 7904294 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-2630 (Electronic) Linking ISSN: 01655701 NLM ISO Abbreviation: Int Ophthalmol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Dordrecht : Kluwer Original Publication: The Hague, Junk. |
مواضيع طبية MeSH: | Iodine Radioisotopes*/adverse effects , Iodine Radioisotopes*/therapeutic use , Thyroid Neoplasms*/radiotherapy , Lacrimal Apparatus Diseases*/etiology , Lacrimal Apparatus Diseases*/diagnosis , Lacrimal Apparatus Diseases*/physiopathology , Lacrimal Apparatus*, Humans ; Dry Eye Syndromes/etiology ; Dry Eye Syndromes/diagnosis ; Dry Eye Syndromes/physiopathology ; Radiation Injuries/etiology ; Radiation Injuries/diagnosis ; Radiation Injuries/physiopathology ; Quality of Life ; Nasolacrimal Duct/radiation effects |
مستخلص: | Purpose: The most prevalent lacrimal apparatus dysfunctions associated with differentiated thyroid cancer(DTC) after I-131 therapy are dry eye and nasolacrimal duct obstruction(NLDO), leading to ocular discomfort and lower quality of life for patients. It is crucial to diagnose and manage lacrimal apparatus dysfunction associated with I-131 therapy for DTC. Therefore, this review aims to comprehensively summarize and analyze the advances in mechanisms and therapeutic options underlying lacrimal apparatus dysfunction induced by I-131 therapy for DTC. Methods: A comprehensive search of CNKI, PubMed, and Wed of Science was performed from the database to December of 2023. Key search terms were "Thyroid cancer", "I-131", "Complications", "Dry eye", "Epiphora", "Tear", "Nasolacrimal duct" and "NLDO". Results: The research indicates that I-131 therapy for DTC causes damage to the lacrimal glands and nasolacrimal duct system, resulting in symptoms such as dry eye, epiphora, and mucoid secretions. Moreover, recent research has focused on exploring relevant risk factors of the condition and experimental and clinical treatments. However, there is some controversy regarding the mechanisms involved, whether it is due to the passive flow of I-131 in tears, active uptake of I-131 by the sodium-iodide symporter (NIS) in the lacrimal sac and nasolacrimal duct, or secondary metabolic and hormonal disturbances caused by I-131. Conclusion: It is crucial for early detection and preventive measures by ophthalmologists and the need for further studies to elucidate the mechanisms underlying the disease. (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.) |
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معلومات مُعتمدة: | 82271094 National Natural Science Foundation of China |
فهرسة مساهمة: | Keywords: DTC; Dry eye; I-131 therapy; NIS; NLDO; Therapies |
المشرفين على المادة: | 0 (Iodine Radioisotopes) 0 (Iodine-131) |
تواريخ الأحداث: | Date Created: 20240622 Date Completed: 20240622 Latest Revision: 20240626 |
رمز التحديث: | 20240627 |
DOI: | 10.1007/s10792-024-03192-9 |
PMID: | 38909080 |
قاعدة البيانات: | MEDLINE |
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