دورية أكاديمية
Advancements in unravelling the fundamental function of the ATAD3 protein in multicellular organisms.
| العنوان: | Advancements in unravelling the fundamental function of the ATAD3 protein in multicellular organisms. |
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| المؤلفون: | Goel D; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India., Kumar S; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India. Electronic address: sudhir.1685@gmail.com. |
| المصدر: | Advances in biological regulation [Adv Biol Regul] 2024 Aug; Vol. 93, pp. 101041. Date of Electronic Publication: 2024 Jun 18. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 101572336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-4934 (Electronic) Linking ISSN: 22124926 NLM ISO Abbreviation: Adv Biol Regul Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Elsevier |
| مواضيع طبية MeSH: | ATPases Associated with Diverse Cellular Activities*/metabolism , ATPases Associated with Diverse Cellular Activities*/genetics , Mitochondria*/metabolism , Mitochondria*/genetics , Mitochondrial Proteins*/metabolism , Mitochondrial Proteins*/genetics , Membrane Proteins*/metabolism , Membrane Proteins*/genetics , Neoplasms*/metabolism , Neoplasms*/genetics , Neoplasms*/pathology, Humans ; Animals ; Mitochondrial Membranes/metabolism ; Endoplasmic Reticulum/metabolism ; Mitophagy |
| مستخلص: | ATPase family AAA domain containing protein 3, commonly known as ATAD3 is a versatile mitochondrial protein that is involved in a large number of pathways. ATAD3 is a transmembrane protein that spans both the inner mitochondrial membrane and outer mitochondrial membrane. It, therefore, functions as a connecting link between the mitochondrial lumen and endoplasmic reticulum facilitating their cross-talk. ATAD3 contains an N-terminal domain which is amphipathic in nature and is inserted into the membranous space of the mitochondria, while the C-terminal domain is present towards the lumen of the mitochondria and contains the ATPase domain. ATAD3 is known to be involved in mitochondrial biogenesis, cholesterol transport, hormone synthesis, apoptosis and several other pathways. It has also been implicated to be involved in cancer and many neurological disorders making it an interesting target for extensive studies. This review aims to provide an updated comprehensive account of the role of ATAD3 in the mitochondria especially in lipid transport, mitochondrial-endoplasmic reticulum interactions, cancer and inhibition of mitophagy. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: AAA domain containing protein; ATAD3; Cancer; Mitochondria; Mitophagy |
| المشرفين على المادة: | EC 3.6.4.- (ATPases Associated with Diverse Cellular Activities) 0 (ATAD3A protein, human) 0 (Mitochondrial Proteins) 0 (Membrane Proteins) |
| تواريخ الأحداث: | Date Created: 20240623 Date Completed: 20240903 Latest Revision: 20240903 |
| رمز التحديث: | 20240904 |
| DOI: | 10.1016/j.jbior.2024.101041 |
| PMID: | 38909398 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2212-4934 |
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| DOI: | 10.1016/j.jbior.2024.101041 |