دورية أكاديمية
Downregulation of Tnf-α and Cat Expression in a Wistar Rat Diabetic Model during Diabetes Onset.
| العنوان: | Downregulation of Tnf-α and Cat Expression in a Wistar Rat Diabetic Model during Diabetes Onset. |
|---|---|
| المؤلفون: | Arcia CGC; Laboratório de Análises Clínicas - Centro Universitário Saúde ABC/FMABC - Santo André, Brazil., Encinas JFA; Laboratório de Análises Clínicas - Centro Universitário Saúde ABC/FMABC - Santo André, Brazil., Raimundo JRS; Laboratório de Análises Clínicas - Centro Universitário Saúde ABC/FMABC - Santo André, Brazil., Gois KC; Laboratório de Análises Clínicas - Centro Universitário Saúde ABC/FMABC - Santo André, Brazil., Alves BDCA; Laboratório de Análises Clínicas - Centro Universitário Saúde ABC/FMABC - Santo André, Brazil., Perez MM; Laboratório de Análises Clínicas - Centro Universitário Saúde ABC/FMABC - Santo André, Brazil., Gascón TM; Laboratório de Análises Clínicas - Centro Universitário Saúde ABC/FMABC - Santo André, Brazil., Fonseca FLA; Laboratório de Análises Clínicas - Centro Universitário Saúde ABC/FMABC - Santo André, Brazil.; Departamento de Ciências Farmacêuticas, Universidade Federal de São Paulo, Campus Diadema, Diadema, Brazil., Veiga GLD; Laboratório de Análises Clínicas - Centro Universitário Saúde ABC/FMABC - Santo André, Brazil. |
| المصدر: | Current diabetes reviews [Curr Diabetes Rev] 2024 Jun 20. Date of Electronic Publication: 2024 Jun 20. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101253260 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-6417 (Electronic) Linking ISSN: 15733998 NLM ISO Abbreviation: Curr Diabetes Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Saif Zone, Sharjah, U.A.E. ; San Francisco, CA : Bentham Science Publishers, c2005- |
| مستخلص: | Introduction: Diabetes Mellitus (DM) is a metabolic disorder characterized by persistent hyperglycemia and/or insulin resistance. If left uncontrolled, it can lead to a combination of cardiac and renal alterations known as cardiorenal syndrome. Additionally, oxidative stress and inflammation contribute to tissue damage, thereby reducing the life expectancy of individuals with diabetes. Aim: The aim of this study was to identify early molecular markers associated with cardiorenal syndrome, oxidative stress, and inflammation, and to investigate their correlation with the duration of exposure to DM. Methods: An experimental DM model was employed using Wistar rats. The rats were divided into four groups: diabetic rats at 7 days (DM7), diabetic rats at 30 days (DM30), control sham at 7 days (CS7), and control sham at 30 days (CS30). Blood and brain tissue from the brainstem region were collected at 7 and 30 days after confirming DM induction. Gene expression analysis of Bnp, Anp, Cat, Gpx, Sod, Tnf-α, and Il-6 was performed. Results: The analysis revealed lower expression values of Cat in the brainstem tissue of the DM7 group compared to the NDS7 group. Moreover, diabetic animals exhibited statistically lower levels of Tnf-α in their peripheral blood compared to the control animals. Conclusion: This study concluded that DM alters the oxidative balance in the brainstem after 7 days of DM induction, resulting in lower Cat expression levels. Although some genes did not show statistical differences after 30 days of DM induction, other genes exhibited no expression values, indicating possible gene silencing. The study identified an imbalance in the studied pathways and concluded that the organism undergoes a compensatory state in response to the initial metabolic alterations caused by DM. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| فهرسة مساهمة: | Keywords: Diabetes mellitus; biomarkers.; cardiorenal syndrome; metabolic syndrome; natriuretic peptides |
| تواريخ الأحداث: | Date Created: 20240624 Latest Revision: 20240624 |
| رمز التحديث: | 20240624 |
| DOI: | 10.2174/0115733998264880230919062657 |
| PMID: | 38910479 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1875-6417 |
|---|---|
| DOI: | 10.2174/0115733998264880230919062657 |