دورية أكاديمية
The Importance of Monitoring Non-clonal Chromosome Aberrations (NCCAs) in Cancer Research.
| العنوان: | The Importance of Monitoring Non-clonal Chromosome Aberrations (NCCAs) in Cancer Research. |
|---|---|
| المؤلفون: | Heng E; Stanford University, Stanford, CA, USA., Thanedar S; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA., Heng HH; Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA. hheng@med.wayne.edu.; Department of Pathology, Wayne State University School of Medicine, Detroit, MI, USA. hheng@med.wayne.edu. |
| المصدر: | Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2024; Vol. 2825, pp. 79-111. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Totowa, NJ : Humana Press Original Publication: Clifton, N.J. : Humana Press, |
| مواضيع طبية MeSH: | Neoplasms*/genetics , Chromosome Aberrations*, Humans ; Chromosomal Instability ; Cytogenetic Analysis/methods ; Karyotyping/methods |
| مستخلص: | Cytogenetic analysis has traditionally focused on the clonal chromosome aberrations, or CCAs, and considered the large number of diverse non-clonal chromosome aberrations, or NCCAs, as insignificant noise. Our decade-long karyotype evolutionary studies have unexpectedly demonstrated otherwise. Not only the baseline of NCCAs is associated with fuzzy inheritance, but the frequencies of NCCAs can also be used to reliably measure genome or chromosome instability (CIN). According to the Genome Architecture Theory, CIN is the common driver of cancer evolution that can unify diverse molecular mechanisms, and genome chaos, including chromothripsis, chromoanagenesis, and polypoidal giant nuclear and micronuclear clusters, and various sizes of chromosome fragmentations, including extrachromosomal DNA, represent some extreme forms of NCCAs that play a key role in the macroevolutionary transition. In this chapter, the rationale, definition, brief history, and current status of NCCA research in cancer are discussed in the context of two-phased cancer evolution and karyotype-coded system information. Finally, after briefly describing various types of NCCAs, we call for more research on NCCAs in future cytogenetics. (© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Chromosome instability; Genome chaos; Heterogeneity; Karyotype coding; Two-phased evolution |
| تواريخ الأحداث: | Date Created: 20240624 Date Completed: 20240624 Latest Revision: 20240624 |
| رمز التحديث: | 20240624 |
| DOI: | 10.1007/978-1-0716-3946-7_4 |
| PMID: | 38913304 |
| قاعدة البيانات: | MEDLINE |
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