دورية أكاديمية
Mechanistic study on vasodilatory and antihypertensive effects of hesperetin: ex vivo and in vivo approaches.
| العنوان: | Mechanistic study on vasodilatory and antihypertensive effects of hesperetin: ex vivo and in vivo approaches. |
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| المؤلفون: | Tew WY; College of Pharmacy, Fujian University of Traditional Chinese Medicine, 1 Qiuyang Road, Shangjie, Minhou, Fuzhou, 350122, Fujian, China.; Department of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Minden, Pulau Pinang, Malaysia., Tan CS; Material Characterization and Inorganic Spectroscopy, Perkin Elmer Sdn. Bhd., #2.01. Level 2, Wisma Academy, Lot 4A, Jalan 19/1, 46300, Petaling Jaya, Selangor, Malaysia., Yan CS; Department of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Minden, Pulau Pinang, Malaysia., Loh HW; Department of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Minden, Pulau Pinang, Malaysia., Wang X; Department of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Minden, Pulau Pinang, Malaysia., Wen X; College of Pharmacy, Fujian University of Traditional Chinese Medicine, 1 Qiuyang Road, Shangjie, Minhou, Fuzhou, 350122, Fujian, China., Wei X; College of Pharmacy, Fujian University of Traditional Chinese Medicine, 1 Qiuyang Road, Shangjie, Minhou, Fuzhou, 350122, Fujian, China. 2000017@fjtcm.edu.cn., Yam MF; College of Pharmacy, Fujian University of Traditional Chinese Medicine, 1 Qiuyang Road, Shangjie, Minhou, Fuzhou, 350122, Fujian, China. yammunfei@yahoo.com.; Department of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Minden, Pulau Pinang, Malaysia. yammunfei@yahoo.com. |
| المصدر: | Hypertension research : official journal of the Japanese Society of Hypertension [Hypertens Res] 2024 Sep; Vol. 47 (9), pp. 2416-2434. Date of Electronic Publication: 2024 Jun 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9307690 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1348-4214 (Electronic) Linking ISSN: 09169636 NLM ISO Abbreviation: Hypertens Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2009- : London : Nature Publishing Group Original Publication: Toyonaka, Japan : The Society, c1992-2003 |
| مواضيع طبية MeSH: | Hesperidin*/pharmacology , Antihypertensive Agents*/pharmacology , Vasodilation*/drug effects , Rats, Sprague-Dawley*, Animals ; Male ; Rats ; Blood Pressure/drug effects ; Hypertension/drug therapy ; Hypertension/physiopathology ; Rats, Inbred SHR ; Vasodilator Agents/pharmacology ; Nitric Oxide/metabolism ; Signal Transduction/drug effects ; Muscle, Smooth, Vascular/drug effects ; Muscle, Smooth, Vascular/metabolism ; Cyclic GMP/metabolism |
| مستخلص: | Hesperetin is one of the prominent flavonoids found in citrus fruit. Several research studies have reported that hesperetin can promote vasodilation in vascular tissue by increasing the level of nitric oxide and cyclic nucleotides. However, these may not be the only pathway for hesperetin to exert its vasodilatory effect. In addition to vasodilation, hesperetin has been found to carry an antihypertensive effect through intraperitoneal injection, although no study has comprehensively investigated the antihypertensive effect of hesperetin through oral administration. Therefore, this study aimed to determine the possible mechanism pathways involved in hesperetin-induced vasodilation and investigated its antihypertensive effects on hypertensive rats' model via oral administration. The ex vivo experimental findings showed that the NO/sGC/cGMP signalling pathway was involved in hesperetin-mediated vasodilation. Moreover, hesperetin activated the AC/cAMP/PKA pathway through PGI (© 2024. The Author(s), under exclusive licence to The Japanese Society of Hypertension.) |
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| فهرسة مساهمة: | Keywords: Antihypertensive effect; Cardiovascular; Hesperetin; Signalling mechanism; Vasodilation |
| المشرفين على المادة: | E750O06Y6O (Hesperidin) Q9Q3D557F1 (hesperetin) 0 (Antihypertensive Agents) 0 (Vasodilator Agents) 31C4KY9ESH (Nitric Oxide) H2D2X058MU (Cyclic GMP) |
| تواريخ الأحداث: | Date Created: 20240624 Date Completed: 20240905 Latest Revision: 20240911 |
| رمز التحديث: | 20240912 |
| DOI: | 10.1038/s41440-024-01652-4 |
| PMID: | 38914702 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1348-4214 |
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| DOI: | 10.1038/s41440-024-01652-4 |