دورية أكاديمية
Relationships of serum MMP-7 and clinical characteristics in choledochal cyst children.
| العنوان: | Relationships of serum MMP-7 and clinical characteristics in choledochal cyst children. |
|---|---|
| المؤلفون: | Yin T; Capital Institute of Pediatrics-Peking University Teaching Hospital, Beijing, China.; Department of General Surgery, Capital Institute of Pediatrics, Beijing, China., Chen S; Department of Pediatric Urology, Fujian Children's Hospital, Fujian, China., Zhou R; Department of General Surgery, Capital Institute of Pediatrics, Beijing, China., Liu W; Department of General Surgery, Capital Institute of Pediatrics, Beijing, China., Diao M; Department of General Surgery, Capital Institute of Pediatrics, Beijing, China. psps3001@hotmail.com.; Research Unit of Minimally Invasive Pediatric Surgery on Diagnosis and Treatment, Chinese Academy of Medical Sciences 2021RU015, Beijing, China. psps3001@hotmail.com., Li L; Department of General Surgery, Capital Institute of Pediatrics, Beijing, China. lilong_pediatric20@163.com.; Research Unit of Minimally Invasive Pediatric Surgery on Diagnosis and Treatment, Chinese Academy of Medical Sciences 2021RU015, Beijing, China. lilong_pediatric20@163.com.; Department of Pediatric Surgery, Tsinghua University Affiliated Beijing Tsinghua Changgung Hospital, Beijing, China. lilong_pediatric20@163.com. |
| المصدر: | BMC surgery [BMC Surg] 2024 Jun 24; Vol. 24 (1), pp. 195. Date of Electronic Publication: 2024 Jun 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968567 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2482 (Electronic) Linking ISSN: 14712482 NLM ISO Abbreviation: BMC Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2001- |
| مواضيع طبية MeSH: | Choledochal Cyst*/diagnosis , Choledochal Cyst*/blood , Matrix Metalloproteinase 7*/blood, Humans ; Male ; Female ; Child, Preschool ; Prospective Studies ; Infant ; Child ; Biomarkers/blood ; gamma-Glutamyltransferase/blood ; Liver Cirrhosis/blood ; Liver Cirrhosis/diagnosis |
| مستخلص: | Background: Matrix metalloproteinase-7 (MMP-7) is associated with biliary injury. This study aimed to evaluate the relationships of serum MMP-7 with clinical characteristics in choledochal cysts (CDC) children. Methods: Between June 2020 and July 2022, we conducted a prospective study of CDCs who underwent one-stage definitive operation at our center. Serum MMP-7 was measured using an enzyme-linked immunosorbent assay. We evaluated the relationships between serum MMP-7 and age, laboratory tests, imaging examinations, liver fibrosis, MMP-7 expression, and perforation. Results: A total of 328 CDCs were enrolled in the study, with a median serum MMP-7 of 7.67 ng/mL. Higher serum MMP-7 was correlated with younger age at diagnosis (p < 0.001), larger cyst sizes (p < 0.001), higher liver fibrosis stages (p < 0.001), and higher incidence of perforation (p < 0.01). Liver MMP-7 was mainly expressed in intrahepatic and extrahepatic biliary epithelial cells. The area under the receiver operating characteristic curve (AUROC) was 0.630 (p < 0.001) for serum MMP-7 in predicting perforation. When serum MMP-7 was combined with γ-glutamyl transferase (GGT), the AUROC increased to 0.706 (p < 0.001). Conclusions: Serum MMP-7 was associated with biliary obstruction in CDCs. Patients with high serum MMP-7 were more likely to have severe liver damage and biliary injury, with higher incidences of liver fibrosis and perforation. (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | FFL2022110 Beijing Hospital Authority's Ascent Plan; 2020-2-2103 Capital's Funds for Health Improvement and Research; 2021RU015 Research Unit of Minimally Invasive Pediatric Surgery on Diagnosis and Treatment, Chinese Academy of Medical Sciences |
| فهرسة مساهمة: | Keywords: Children.; Choledochal cyst; Liver fibrosis; MMP-7; Perforation |
| المشرفين على المادة: | EC 3.4.24.23 (Matrix Metalloproteinase 7) EC 3.4.24.23 (MMP7 protein, human) 0 (Biomarkers) EC 2.3.2.2 (gamma-Glutamyltransferase) |
| تواريخ الأحداث: | Date Created: 20240624 Date Completed: 20240624 Latest Revision: 20240708 |
| رمز التحديث: | 20240708 |
| مُعرف محوري في PubMed: | PMC11194885 |
| DOI: | 10.1186/s12893-024-02488-y |
| PMID: | 38914992 |
| قاعدة البيانات: | MEDLINE |
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