دورية أكاديمية
أعرض في EDS

HIV infection and ART use are associated with altered plasma clot characteristics in Black South Africans.

التفاصيل البيبلوغرافية
العنوان: HIV infection and ART use are associated with altered plasma clot characteristics in Black South Africans.
المؤلفون: Bakali S; Faculty of Health Sciences, Centre of Excellence for Nutrition (CEN), North-West University, Potchefstroom Campus, Potchefstroom, South Africa., de Lange-Loots Z; Faculty of Health Sciences, Centre of Excellence for Nutrition (CEN), North-West University, Potchefstroom Campus, Potchefstroom, South Africa.; Faculty of Health Sciences, SAMRC Extramural Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa., Jordaan A; Laboratory for Electron Microscopy, Chemical Resource Beneficiation (CRB), North-West University, Potchefstroom Campus, Potchefstroom, South Africa., Pieters M; Faculty of Health Sciences, Centre of Excellence for Nutrition (CEN), North-West University, Potchefstroom Campus, Potchefstroom, South Africa.; Faculty of Health Sciences, SAMRC Extramural Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa.
المصدر: PloS one [PLoS One] 2024 Jun 25; Vol. 19 (6), pp. e0305826. Date of Electronic Publication: 2024 Jun 25 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: HIV Infections*/drug therapy , Fibrinogen*/metabolism , Fibrinogen*/analysis , Black People* , Blood Coagulation*/drug effects, Humans ; Female ; South Africa/epidemiology ; Adult ; Male ; Middle Aged ; Case-Control Studies ; African People
مستخلص: Background: Human immunodeficiency virus (HIV) and antiretroviral treatment (ART) are both associated with hypercoagulability. Altered clot properties could be a potential mechanism thereof. We aimed to investigate the association of HIV and ART, with fibrinogen and plasma clot properties in a group of Black South Africans.
Methods: At baseline, 151 newly diagnosed people living with HIV (PLWH) and 176 controls were recruited. Some PLWH subsequently commenced with ARTs (n = 70) while others remained ART-naïve (n = 81). Fibrinogen and clot properties (turbidity assay) were investigated from baseline to 5-year follow-up. A sub-group of 21 women (n = 10 ART-treated; n = 11 ART-naïve) with HIV was systematically selected and matched with 12 controls, and additional clot properties (rheometry, permeability and fibre diameter) were investigated.
Results: Fibrinogen was lower in the HIV groups compared to the controls, while % γ' fibrinogen was higher. PLWH had shorter lag times and lower maximum absorbance than the controls (p<0.05). Their CLTs on the other hand were longer. Most variables increased over time in all groups, but differences in the degree of change over time was observed for lag time (p = 0.024) and permeability (p = 0.03). Participants who commenced with ART had a tendency of delayed clot formation (p = 0.08) and increased clot permeability (p = 0.005).
Conclusion: PLWH had lower total fibrinogen concentration and formed less dense clots. They also formed clots that were more difficult to lyse, which likely not resulted from altered clot properties. ART use (NNRTI's) had a moderately protective effect, delaying clot formation, and increasing clot permeability.
Competing Interests: None of the authors have any competing interests to declare.
(Copyright: © 2024 Bakali et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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المشرفين على المادة: 9001-32-5 (Fibrinogen)
تواريخ الأحداث: Date Created: 20240625 Date Completed: 20240625 Latest Revision: 20240828
رمز التحديث: 20240828
مُعرف محوري في PubMed: PMC11198788
DOI: 10.1371/journal.pone.0305826
PMID: 38917149
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0305826